Beta Cross Laps measures C-terminal telopeptide of mature Type 1 collagen and has been proposed as a reliable specific marker for bone resorption. The levels are elevated with increased bone resorption in patients. This assay helps in monitoring the therapeutic effects of estrogen replacement therapy on bone mineral density and bone turnover in postmenopausal women treated for osteoporosis and individuals diagnosed with osteopenia. Increased levels are associated with Hyperparathyroidism, Hyperthyroidism, Paget’s disease, Osteopenia, and Osteoporosis. It is useful in determining the abnormalities in the bone remodeling process and can be used to monitor the rate of bone loss in various metabolic bone disorders. An addition to the diagnosis of a medical condition that is associated with increased bone turnover.