Lupus erythematosus (LE) is a non-specific immune disorder. It is caused by antibodies which are defense proteins that attack the own tissue of the bodies instead of foreign invaders. LE affects a wide range of tissues including skin, kidney, heart, brain, lungs, and joints. An LE cells are either a macrophage or neutrophil which has engulfed degraded nuclear material from another cell. LE cell detection is made through microscopic examination. Flow cytometric analysis is a specialized testing which also helps in detecting LE cell in an automated manner. Le cell blood test is a screening test for lupus which detects lupus cells. Adults are most commonly affected by lupus.