Parvovirus B19 is a human pathogen transmitted to susceptible individuals via respiratory secretions and contaminated blood or blood products. It is a non-enveloped single-stranded DNA virus that infects, replicates in, and lyses red cell progenitors. The presence of this viral DNA may result in an asymptomatic infection or produce a wide spectrum of disease ranging from erythema infections (slapped cheek syndrome or fifth disease) in children to arthropathy, severe anaemia, and systemic manifestations involving the central nervous system, heart, and liver depending on the immunity of the patient. Acute infections are diagnosed by detecting IgG and IgM class antibodies in the serum with enzyme-linked immunosorbent assay testing using polymerase chain reaction (PCR).