Sperm wash was first introduced in 1992 in Milan, Italy by Augusto Enrico Semprini and colleagues, with the aim of helping HIV positive Sperm washing is a term used in fertility clinics and treatment centers. Sperm wash is a process of cleaning dead and slow moving sperm as well as other chemicals which leads to impair fertilization. These sperms are used in Intrauterine insemination (IUI) (is a fertility treatment that places sperm directly into the uterus). It also removes white blood cells, mucus and prostaglandins that may hinder fertilization. Prostaglandins a chemical that is present in seem causes muscular contractions and cramps during pregnancy.