Lidocaine (Lignocaine), introduced in 1946, represents the most common local anesthetic (LA) agent employed in local or regional anesthesia. LA is commonly used in dentistry, ophthalmology, minor surgery, and obstetrics. Most allergic reactions are due to cross-reactivity among metabolic product of the ester local anesthetic and para-aminobenzoic acid. True allergy to LA is very rare, with only 1% of all genuine immunological reaction against this medicine. Skin testing is considered to be a useful tool in case of suspected hypersensitivity to local anesthetics. The tests include patch tests, intradermal tests for delayed hypersensitivity, intradermal tests for immediate reactions and skin prick test.