A Barbiturates is a drug and it acts as a central nervous system depressant and therefore can create the wide spectrum of effects from the mild sedation to the total anaesthesia. They are also very effective as hypnotics, anxiolytics, and anticonvulsants. It has great addition potential both psychologically and physically. Barbiturates have been continuously used for various treatments of cluster headaches or migraines, capital punishments, assisted suicide and euthanasia. It is been replaced largely by benzodiazepines in regular medical practices. It affects the body in so many ways which can harm the body mentally and physically.