Anti Phospholipase A2 Receptor Test

Anti Phospholipase A2 Receptor Antibodies test is performed on a sample of blood to measure the level of Anti Phospholipase A2 Receptor in the blood. Membranous nephropathy (MN) is a common cause of idiopathic nephritic syndrome in adults. The formation of subepithelial immune deposits and complement activation result in alterations of the basement membrane structure and damage to the filtration barrier, causing Proteinuria. The disease process is initiated with the binding of circulating auto antibodies to target antigens on the podocyte. It is performed to confirm Membranous Nephropathy, Hematuria, Kidney Disorder and Proteinuria and is also performed during and after the treatment.

No special preparation is needed for Anti Phospholipase A2 Receptor Antibodies Elisa Blood. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Anti Phospholipase A2 Receptor Antibodies Elisa Blood. Your doctor depending on your condition will give specific instructions.

Distinguishing primary from secondary membranous nephropathy Anti-Phospholipase A2 receptor (PLA2R) antibodies are highly specific for the diagnosis of primary membranous nephropathy. 70% to 75% of patients with primary membranous nephropathy are positive for anti-PLA2R.

Anti Phospholipase A2 Receptor test is done using ELISA method on a Blood sample. Method Used: EURO: Enzyme-Linked Immunosorbent Assay (ELISA): The ELISA test procedure: A tourniquet, or band, will be applied around your arm to create pressure and cause your veins to swell with blood and needle is inserted to take blood sample. The procedure may be relatively painless, but your arm may throb a little after it’s done. For performing the lab test of the sample, it will be added to a petridish containing the specific antigen related to the condition for which you are being tested. If your blood contains antibodies to the antigen, the two will bind together. It will be checked by adding an enzyme to the petridish and observing how blood reacts with antigen. The result may be positive if the contents of the dish change color. How much change the enzyme causes allows the lab tester to determine the presence of amount of antibody.