Chikungunya Antibody IgG Test

Chikungunya virus (ChikV) is a single-stranded RNA alphavirus and a member of the Togaviridae family of viruses. The name Chikungunya is derived from the language of the Makonde ethnic groups in southeast Africa and means 'that which bends' or 'stooped walk'. The test aids in the diagnosis of recent infection with Chikungunya virus in patients with recent travel to endemic areas and a compatible clinical syndrome. Specimens collected too early following infection may be negative for antibodies to Chikungunya virus. Testing of convalescent serum is recommended.

No special preparation is needed for Chikungunya Antibodies. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Chikungunya Antibodies. Your doctor depending on your condition will give specific instructions. IgM antibodies to ChikV typically remain detectable for 3 to 4 months after infection, whereas IgG antibodies to ChikV remain detectable for years.

The normal result for Chikungunya Antibodies for Chikungunya Antibodies - IgA is The antibodies are not normally present. Presence of IgA antibodies indicates infection for Unisex gender and for All age groups. Chikungunya Antibodies - IgM is The antibodies are not normally present. Presence of IgM antibodies indicates recent infection for Unisex gender and for All age groups. Chikungunya Antibodies - IgG is The antibodies are not normally present. Presence of IgG antibodies indicates past infection for Unisex gender and for All age groups.

For both the Chikungunya virus IgM and IgG assays, polystyrene microwells are coated with recombinant Chikungunya antigen. Diluted serum samples and controls are incubated in the wells to allow anti-Chikungunya antibodies (if present in the sample) to react with the antigen. Nonspecific reactants are removed by washing. Next, peroxidase-conjugated antihuman antibody is added to the wells and will react with human antibodies bound to the antigen. Excess conjugate is removed by washing. Enzyme substrate and chromogen are added, and the color is allowed to develop. After adding the Stop Reagent, the resultant color change is quantified by a spectrophotometric reading of optical density (OD). Sample optical density readings are compared with reference cut-off OD readings to determine the qualitative results.