IHC - B-Cell Leukemia/Lymphoma 2 Test

Nowadays, Lymphoma is the most common type of blood cancer. Lymphomas are basically biologically complex neoplasms of the immune system. It is a condition in which the white blood cells continue to multiply itself without any sort of barrier. The most common forms of Lymphoma are Hodgkin lymphoma and non-Hodgkin lymphoma. It has been found that the cancerous lymphocytes can easily migrate to various parts of the body, including the lymph nodes, spleen, bone marrow, blood or other organs. They can also accumulate to form tumors. IHC-B-Cell-Leukemia-Lymphoma-2 test provides the doctor with a clear idea about the present condition of the white blood cells in the body. Thus, enabling the doctor to get a better understanding of the current situation. This, in turn, helps them to pursue the best possible treatment for the patient.

Since the test involves the collection of a sample of peripheral blood, fresh bone marrow, and fresh or unfixed tissue, hence there are no special arrangements that are required to be made. The patients can easily follow their regular diet schedule. However, the patients must follow all the basic instructions as given by the doctor. They must also do well to keep the doctors updated about their medical history. In addition to this, they must also inform the doctors if they are allergic to any drug or any specific kind of medication. Depending on all the information as given the patient, the doctor decides the procedure by which the test shall be conducted, and also the area from where the sample is required to be obtained.

IHC-B-Cell-Leukemia-Lymphoma-2 test is highly useful for the purpose of detecting the presence of cancerous cells arising due to the abnormal growth of white blood cells. They are useful for identifying and characterizing the following – Reactive lymphocytosis against chronic lymphocytic leukemia. CLL against mantle cell lymphoma. Prolymphocytic leukemia against lymphoblastic leukemia, along with large granular lymphocyte proliferations. Detailed study of Sézary syndrome. Non-Hodgkin lymphoma and Adult T-cell leukemia or lymphoma.

The method of Immunophenotyping by flow cytometry is strictly followed when conducting IHC-B-Cell-Leukemia-Lymphoma-2 test. 1 ml of peripheral blood is first obtained by injecting a needle through the veins of the arm. Fresh bone marrow for core biopsy is then collected and carefully stored in a glass container with the name of the patient written on the label. Last but not the least, fresh or unfixed tissue is obtained in RPMI. All the samples are then sent to the laboratory for further investigation