Cefotaxime

Cefotaxime, is a cephalosporin antibiotic, a type of 'broad spectrum' anti-biotic which acts against numerous Gram-negative and Gram-positive bacteria. This medicine is primarily prescribed for treatment of susceptible infection in respiratory tract, skin and skin structure.

Specifically it treats joint infections, meningitis, pelvic inflammatory disease, pneumonia, sepsis, urinary tract infections, gonorrhea, and cellulitis. It is administered into the body by injecting it either into a vein or a muscle.

The recommended dose in adults is 0.5 grams a day to 12 grams divided into multiple doses per day. It is advised not to take this medicine if one is hypersensitive to Cefotaxime or other cephalosporins. Some medical conditions may interact with it, so inform your doctor if you have any of the medical conditions mentioned below :

• If you are pregnant or planning to soon be pregnant, or breastfeeding.
• If you are already taking any medication, dietary supplement or herbal preparation.
• If you are allergic to food, medicines or other any other substances.
• If you have had a history of stomach or bowel problems, kidney problems or poor nutrition.

Cefotaxime can cause a few side effects like pain and inflammation at the site of injection/infusion, nausea and vomiting, rash, diarrhoea, pruritus, or fever. The dose your doctor recommends will be based on your age, weight, kidney function, other medications you are taking and how you respond to this medicine.

Continue this medication for the full time prescribed, even if the symptoms seem to disappear after few days. Discontinuing the medication too early may result in recurrance of the infection.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Bacterial Meningitis

• Bacterial Septicemia

• Gonococcal Infection

• Urinary Tract Infection

• Pneumonia

• Osteomyelitis

• Respiratory Tract Infection

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Allergy

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Rash

• Pruritus

• Diarrhoea

• Nausea

• Vomiting

• Colitis

• Urticaria

• Neutropenia

• Thrombocytopenia

• Headache

• Fever

• Seizures

• Cholestasis

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• How long is the duration of effect?

  This medicine is excreted largely in urine and the effect lasts for a duration of 4 to 6 hours.

• What is the onset of action?

  The peak effect of this medicine can be observed within 30 minutes of intramuscular injection.

• Are there any pregnancy warnings?

  Limited data is available on the use of this medicine in pregnant women. Use only if clearly needed under the supervision of the doctor.

• Is it habit forming?

  No habit forming tendency has been reported.

• Are there any breast-feeding warnings?

  This medicine can be used by breastfeeding women. Small amount of this medicine is excreted in human breast milk. Monitoring of undesired effects like diarrhea or thrush is necessary.

• Is It safe with alcohol?

  Consumption of alcohol along with this medicine does not cause any harmful side effects.

• Is it safe to drive while on this medicine?

  This medicine might affect the patients alertness and hence cause blurring vision or make your sleepy or dizziness. If any of these symptoms occur, do not drive.

• Does this affect liver function?

  Moderate dosage reduction is recommended in severe liver disease. Kindly consult your doctor before taking it.

• Does this affect kidney function?

  Caution must be taken while taking this medicine. Adjustment of the dose is needed. Dosing interval in renal impairment:

  • Clcr 10-50 mL/minute: Administer every 8-12 hours
  • Clcr <10 mL/minute: Administer every 24 hours
  • Hemodialysis: Moderately dialyzable

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Missed Dose instructions

  The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of overdose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Below is the list of medicines, which contains Cefotaxime as ingredient

• Ceflin 500 MG Injection

  Lincoln Pharmaceuticals Ltd

• Taxim 250 MG Injection

  Alkem Laboratories Ltd

• Cefotax 250 MG Injection

  Abbott Healthcare Pvt. Ltd

• Stancef 1000 MG Injection

  Ranbaxy Laboratories Ltd

• Ceflin 1000 MG Injection

  Lincoln Pharmaceuticals Ltd

• Cefentral 1000 MG Injection

  Lupin Ltd

• Cefaxil 1000 MG Injection

  Leben Laboratories Pvt.Ltd

• Cefatal 1000 MG Injection

  Alembic Ltd

• Cefantral 1000 MG Injection

  Lupin Ltd

• C Tax 1000 MG Injection

  Zuventus Healthcare Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

This medication belongs to the third-generation cephalosporins. It works as a bactericidal by inhibiting the bacterial cell wall synthesis by binding to penicillin-binding proteins which would inhibit the growth and multiplication of bacteria.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Lab Test

  Positive direct Coombs', false-positive urinary glucose test using cupric sulfate (Benedict's solution, Clinitest®, Fehling's solution), false-positive serum or urine creatinine with Jaffé reaction.

• Interaction with Medicine

  • Increased effect: Probenecid may decrease cephalosporin elimination.
  • Increased toxicity: Furosemide, aminoglycosides may be a possible additive to nephrotoxicity.

• Interaction with Food

  Information not available.

• Interaction with Disease

  • Modify dosage in patients with severe renal impairment; prolonged use may result in superinfection; a potentially life-threatening arrhythmia has been reported in patients who received a rapid bolus injection via central line.
  • Use caution in patients with colitis; minimize tissue inflammation by changing infusion sites when needed.
  • Use with caution in patients with a history of penicillin allergy especially IgE-mediated reactions (eg, anaphylaxis, urticaria); may cause antibiotic-associated colitis or colitis secondary to C. difficile.

• Ques : What is Cefotaxime used for?

  Ans : Cefotaxime is used in the treatment of joint infections, cellulitis, sepsis, gonorrhoea, pelvic inflammatory disease, urinary tract infections, pneumonia, and meningitis.

• Ques : How long Cefotaxime takes to show its effect?

  Ans : The onset of action of Cefotaxime is now known, however, the body starts to get better after 3 to 5 days of taking medicine.

• Ques : What is the duration of the effect of Cefotaxime?

  Ans : The effect of Cefotaxime lasts for about 12 hours.

• Ques : Should Cefotaxime be taken with a meal or without a meal?

  Ans : It is recommended to take Cefotaxime with a meal to prevent an unsettled stomach.

• Ques : How is Cefotaxime administered?

  Ans : Cefotaxime is administered intravenously.

• Ques : Is it safe to stop taking Cefotaxime suddenly?

  Ans : It is advised to not stop taking Cefotaxime without a doctor’s instruction as doing so may worsen the health condition.

• Cefotaxime-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 30 May 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/cefotaxime

• Cefotaxime-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 30 May 2022].Available from:

  https://go.drugbank.com/drugs/DB00493

• CEFTAZIDIME injection,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 30 May 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=CEFOTAXIME