Crixan 1% Gel

As a macrolide antibiotic, Clarithromycin is used in the treatment of infections caused by bacteria. The infections may include pneumonia, respiratory tract infections, lyme disease, strep throat, skin infections, H. pylori infection, among others.

Crixan 1% Gel is also indicated for prophylaxis of bacterial endocarditis in patients who are allergic to penicillin and undergoing surgical or dental procedures.

It is categorised as a broad-spectrum antibiotic which protects against mycoplasma, chlamydia and mycobacteria and other gram-negative and gram-positive bacteria. It works by decreasing protein production of these bacteria. It is available in the form of tablets, pills and liquids.

Crixan 1% Gel is indicated for the treatment of duodenal ulcer disease due to H. pylori in regimens with other drugs including amoxicillin and lansoprazole or omeprazole, ranitidine, bismuth citrate, bismuth subsalicylate, tetracycline and/or an H2-antagonist.

In children, for treatment of pharyngitis/tonsillitis, acute maxillary sinusitis, acute otitis media, uncomplicated skin/skin structure infections due to the above organisms; treatment of and prevention of disseminated mycobacterial infections due to M. avium complex disease (eg, patients with advanced HIV infection).

The amount your doctor prescribes and how long you take it depend on your age, medical condition and its severity and your reaction to the first dose.Take full course of therapy; do not discontinue without consulting prescriber.

Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). You may experience nausea (small frequent meals, or sucking lozenges may help); abnormal taste (frequent mouth care or chewing gum may help); diarrhea, headache, or abdominal cramps (medication may be ordered).

Report persistent fever or chills, easy bruising or bleeding, or joint pain. Report severe persistent diarrhea, skin rash, sores in mouth, foul-smelling urine, rapid heartbeat or palpitations, or difficulty breathing. Do not refrigerate oral suspension (more palatable at room temperature).

Symptoms of overdose include nausea, vomiting, diarrhea, prostration, reversible pancreatitis, hearing loss with or without tinnitus or vertigo. Treatment includes symptomatic and supportive care.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Pharyngitis/Tonsillitis

• Bronchitis

• Pneumonia

• Helicobacter Pylori Infection

• Skin And Structure Infection

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Allergy

• Impaired Liver Function

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Headache

• Diarrhoea

• Nausea

• Heartburn

• Abdominal Pain

• Shortness Of Breath

• Tremor

• Hypoglycemia

• Anxiety

• Anorexia

• Vomiting

• Dizziness

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 9 to 21 hours for an Immediate release.

• What is the onset of action?

  The peak effect of this drug can be observed in 2 to 3 hours for an immediate release tablet and 5 to 8 hours for an extended release tablet.

• Are there any pregnancy warnings?

  This medicine is not recommended for use during pregnancy unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine.

• Is it habit forming?

  No habit forming tendency has been reported.

• Are there any breast-feeding warnings?

  Women who are breastfeeding must consult doctor before using this drug.

• What is the onset of action?

  The effect of this medicine will be initiated within 60 minutes after its administration.

• How long is the duration of effect?

  The effect of this medicine will remain active for about 10 - 12 hours.

• Does this affect kidney function?

  Caution must be taken while using this in patients with kidney disease. Adjustment of dose might be needed. Usually, decreased doses or prolonged dosing intervals are recommended. Kindly consult your doctor before taking it.

• Does this affect liver function?

  This medicine is probably safe to be used in patients with liver disease. Limited data is available in reference to this. Adjustment of dose might not be needed. Kindly consult your doctor before taking it.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Are there any missed dose instructions?

  The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for your next dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Crixan 1% Gel is a macrolide antibiotic that stops the growth of bacteria by inhibiting protein synthesis. It binds reversibly to the 50S ribosomal subunits which prevent peptidyl transferase activity which in turn interferes with the translocation process thus preventing peptide chain elongation.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Lab Test

  Information not available.

• Interaction with Medicine

  • Clarithromycin increases serum theophylline levels by as much as 20%.
  • Increased concentration of HMG CoA-reductase inhibitors (lovastatin and simvastatin).
  • Amprenavir's serum concentration may be increased.
  • Significantly increases carbamazepine levels and those of cyclosporine, digoxin, ergot alkaloid, tacrolimus, omeprazole and triazolam.
  • Peak levels (but not AUC) of zidovudine are often increased; terfenadine and astemizole should be avoided with use of clarithromycin since plasma levels may be increased by >3 times; serious arrhythmias have occurred with cisapride and other drugs which inhibit cytochrome P-450 3A4 (eg, clarithromycin).
  • Fluconazole increases clarithromycin levels and AUC by ~25%; death has been reported with administration of pimozide and clarithromycin. Concurrent use is contraindicated.

  Note: While other drug interactions (bromocriptine, disopyramide, lovastatin, phenytoin, and valproate) known to occur with erythromycin have not been reported in clinical trials with clarithromycin, concurrent use of these drugs should be monitored closely.

• Interaction with Food

  May be taken with or without meals; may be taken with milk; food delays absorption; total absorption remains unchanged.

• Interaction with Disease

  In presence of severe renal impairment with or without coexisting hepatic impairment, decreased dosage or prolonged dosing interval may be appropriate; antibiotic-associated colitis has been reported with use of clarithromycin; elderly patients have experienced increased incidents of adverse effects due to known age-related decreases in renal function

• Ques : What is Crixan 1% Gel?

  Ans : Crixan 1% Gel is a macrolide antibiotic.

• Ques : What are the uses of the Crixan 1% Gel?

  Ans : Crixan 1% Gel is used in the treatment of infections caused by bacteria.

• Ques : How long do I need to use Crixan 1% Gel before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use Crixan 1% Gel?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Crixan 1% Gel empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : What are the instructions for the storage and disposal of Crixan 1% Gel?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Ques : How long does Crixan 1% Gel take to work?

  Ans : Usually, Crixan 1% Gel starts working soon after taking it. However, it may take some days to kill all the harmful bacteria and make you feel better.

• Ques : What if I don't get better after using Crixan 1% Gel?

  Ans : Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform him if your symptoms are getting worse while using this medicine.

• Ques : Can the use of Crixan 1% Gel cause diarrhea?

  Ans : Yes, the use of Crixan 1% Gel can cause diarrhea. It is an antibiotic which kills the harmful bacteria. However, it also affects the helpful bacteria in your stomach or intestine and causes diarrhea. If you are experiencing severe diarrhea, talk to your doctor about it.

• Ques : Can the use of Crixan 1% Gel cause infertility?

  Ans : There is no firm evidence to suggest that the use of Crixan 1% Gel will cause infertility in males or females.

• Clarithromycin-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 27 May 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/clarithromycin

• Clarithromycin-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 27 May 2022].Available from:

  https://go.drugbank.com/drugs/DB01211

• CLARITHROMYCIN gel,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 27 May 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=CLARITHROMYCIN