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Overview

Dolutegravir

Prescription vs OTC : Prescription by Doctor required

About Dolutegravir

This drug is an antiretroviral medication. It is used in combination with other medicines to treat HIV/AIDS. The medication is also helpful against post-exposure prophylaxis.

It acts as an HIV integrase strand transfer inhibitor and inhibits the functioning of HIV integrase, an enzyme required for replication of the virus.

The dose of this drug should be taken as prescribed by an experienced physician. Those who observe any hypersensitivity reaction after consuming this medication should discontinue using it. The drug is safe to use in children above 6 years of age.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Sexologist before using this medicine.

    What are the uses of Dolutegravir

    • Hiv Infection

    • Aids

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Sexologist before using this medicine.

    What are the contraindications of Dolutegravir ?

    • Hypersensitivity

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Sexologist before using this medicine.

    What are the side effects of Dolutegravir ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Sexologist before using this medicine.

    Key highlights of Dolutegravir

    • How long is the duration of effect?

      The effect of this drug lasts for a duration of 14 hours.

    • What is the onset of action?

      The peak effect is observed within 2 to 3 hours of administration.

    • Are there any pregnancy warnings?

      Taking this drug during pregnancy can cause harm to the fetus. Consult your doctor before consuming it.

    • Is it habit forming?

      No clinical data is available regarding the habit-forming tendencies.

    • Are there any breast-feeding warnings?

      The drug may be unsafe to use during breastfeeding. Consult a doctor before using it.

    • Does this affect kidney function?

      This medication may alter the functioning of the kidney and is not recommended for people who suffer from kidney diseases and other renal problems.

    • Does this affect liver function?

      This medication is not recommended for patients suffering form liver diseases it can lead to other complications. Consult your doctor if you have any queries.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Sexologist before using this medicine.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      The missed dose should be taken as soon as possible.

    • Are there any overdose instructions?

      Consult a doctor in case of overdose.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Sexologist before using this medicine.

    Where is the Dolutegravir approved?

    • India

    • United States

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Sexologist before using this medicine.

    Medicines containing Dolutegravir

    Below is the list of medicines, which contains Dolutegravir as ingredient

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Sexologist before using this medicine.

    How does this medication work?

    The drug is an HIV-1 antiretroviral agent. It prevents the HIV integrase to bind the integrase active site and blocks the strand transfer step of retroviral Deoxyribonucleic acid (DNA) integration which is essential for the HIV replication cycle.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Sexologist before using this medicine.

      What are the interactions of Dolutegravir ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

        test
      • Interaction with Alcohol

        Alcohol

        Alcohol consumption should be limited during the course of medication.

      • Interaction with Medicine

        Medicine

        Do not use this drug in combination with magnesium/aluminum-containing antacid, iron or calcium supplements, multivitamins, etravirine, tipranavir, ritonavir and rifampicin.

      • Interaction with Disease

        Disease

        Patients suffering from liver disease should exercise caution as this drug may worsen the condition. The drug can also cause Immune Reconstitution Syndrome in some cases.

      • Interaction with Food

        Food

        Information not available

      References

      • Dolutegravir-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 9 June 2022].Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/dolutegravir

      • Dolutegravir-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 9 June 2022].Available from:

        https://go.drugbank.com/drugs/DB08930

      • DOLUTEGRAVIR tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 9 June 2022].Available from:

        https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=DOLUTEGRAVIR

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Anil MehtaMBBS, DNB (General Medicine)General Physician
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