Donepezil

Donepezil, a cholinesterase inhibitor, is used to treat a brain disorder that affects the ability to remember, communicate, think clearly, and perform daily activities and may cause changes in mood and personality in people who have Alzheimer's disease. It improves mental function by increasing the amount of certain chemicals in the brain. However, it does not cure Alzheimer’s disease completely. Possible side effects of this medicine include loss of appetite, difficulty sleeping, gastrointestinal upset, vomiting, diarrhoea or muscle cramping.

Certain conditions may require you to be extra careful while taking this medicine. Inform your doctor if you have these conditions :

• Pregnant, planning to become pregnant, or are breast-feeding
• Are taking any other prescribed or over the counter medicines.
• Are allergic to medicines, foods, or other substances.
• A history of certain heart problems, stomach or bowel problems, liver or kidney problems, lung or breathing problems, muscle problems, low thyroid hormone levels, or urinary blockage.
• Brain lesions or tumours, a recent head injury, or a history of seizures
• Have Parkinson disease or metabolism problems

Donepezil comes as a tablet and an orally disintegrating tablet to take by mouth. It is usually taken once a day with or without food, in the evening just before bedtime. Your doctor may prescribe to you a low dose initially to decrease the risk of side effects and gradually increase your dose after 4 to 6 weeks. Your doctor may increase your dose again 3 or more months later. Use this medication regularly in order to get the most benefit from it.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Neurologist before using this medicine.

• Alzheimer's Disease

  Donepezil is used in the treatment of Alzheimer's disease which is a progressive brain disorder characterized by memory loss and difficulty in thinking.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Neurologist before using this medicine.

• Allergy

  Not recommended in patients with known allergy to Donepezil.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Neurologist before using this medicine.

• Diarrhoea

• Loss Of Appetite

• Nausea Or Vomiting

• Trouble Sleeping

• Muscle Cramps

• Dizziness

• Frequent Urination

• Headache

• Weight Loss

• Unusual Bleeding

• Joint Pain

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Neurologist before using this medicine.

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 7 to 8 days.

• What is the onset of action?

  The time taken to reach peak concentration is 3 to 4 hours.

• Are there any pregnancy warnings?

  This medicine is not recommended for pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

• Is it habit forming?

  No habit forming tendency has been reported

• Are there any breast-feeding warnings?

  It is not known whether this medicine is excreted in breast milk. It is not recommended in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Neurologist before using this medicine.

• Missed Dose instructions

  Take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Neurologist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Neurologist before using this medicine.

Below is the list of medicines, which contains Donepezil as ingredient

• Dope 5 MG Tablet

  D.D Pharmaceuticals

• Dopezil 5 MG Tablet

  Ranbaxy Laboratories Ltd

• Donamem 5 Tablet

  Sun Pharmaceutical Industries Ltd

• Aricep 5 MG Tablet

  Eisai Pharmaceuticals India Ltd

• Sanezil 5 MG Tablet

  Sigmund Promedica

• Nozil 5 MG Tablet

  Mankind Pharmaceuticals Ltd

• Donep Odt 5 MG Tablet

  Alkem Laboratories Ltd

• Lapezil 5 MG Tablet

  La Renon

• Donetaz 11.5 MG Tablet

  Sun Pharma Laboratories Ltd

• Amazil 5 MG Tablet

  Emcure Pharmaceuticals Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Neurologist before using this medicine.

Donepezil is cholinesterase inhibitors. It works by increasing the cholinergic function by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Neurologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

test

• Interaction with Alcohol

  Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Lab Test

  Lab

  Information not available.

• Interaction with Medicine

  Carvedilol

  These medicines may lower the heart rate and blood pressure if taken together. Inform the doctor if you are receiving antihypertensives like carvedilol, metoprolol, and nifedipine. Any symptoms of dizziness, irregular heartbeat should be informed to the doctor. Dose adjustment or an alternate medicine should be considered based on the clinical condition.

  Oxcarbazepine

  Inform the doctor if you are receiving oxcarbazepine, carbamazepine as these medicines will decrease the effect of Donepezil. Any symptoms of worsening of the condition should be reported to the doctor. Dose adjustments are to be made based on the clinical condition.

  Tramadol

  These medicines may increase the risk of seizures if taken together. The risk is more in the elderly population with the history of head injury or seizures. Any symptoms of seizures should be informed to the doctor. The dose of either of the medicines should be adjusted based on the clinical condition.

• Interaction with Disease

  Bradycardia

  This medicine is not recommended in patients with existing heart disease. An alternate medicine should be considered based on the clinical condition.

  Lung Disease

  This medicine is not recommended in patients with lung disorders like asthma or COPD. Inform the doctor if you have any symptoms of breathing difficulty. An alternate medicine should be considered based on the clinical condition

• Interaction with Food

  Food

  Information not available.

• Donepezil-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 3 June 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/donepezil

• Donepezil-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 3 June 2022].Available from:

  https://go.drugbank.com/drugs/DB00843

• DONEPEZIL Tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 3 June 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=DONEPEZIL