Esomeprazole

Esomeprazole is used in the treatment of conditions caused by excessive production of acid in the stomach. The conditions may include erosive esophagitis, gastroesophageal reflux disease (GERD), Helicobacter pylori infection and Zollinger-Ellison syndrome (tumors in the pancreas or in the upper part of the small intestine).

Esomeprazole is used for short-term (4-8 weeks) treatment of severe erosive esophagitis (grade 2 or above), diagnosed by endoscopy and short-term treatment of symptomatic gastroesophageal reflux disease (GERD) poorly responsive to customary medical treatment.

It is also used for the treatment of heartburn and other symptoms associated with GERD; pathological hypersecretory conditions; peptic ulcer disease; gastric ulcer therapy; maintenance of healing of erosive esophagitis; approved for combination use in the eradication of H. pylori in patients with active duodenal ulcer.

Apart from that, it can also help in preventing stomach ulcer that is caused due to the consumption of nonsteroidal anti-inflammatory drugs (NSAID). The medication is available as a delayed-release capsule or in the form of a liquid suspension.

Belonging to the drug group of proton pump inhibitors, this medication blocks the proton pump in your stomach’s cells. When this proton pump gets blocked, there will be less production of acid in your stomach.

The dosage of this medication is decided by your doctor based on your age, the severity of the condition, your medical history and the reaction of your body after taking the first dose.

It should be kept in mind that this medicine is processed by the liver. If you have chronic liver disease, the body will be unable to process it well, causing a build-up of the drug. Also, this medicine can pass on to a child through his/her mother by breastfeeding. Hence, both pregnant and breastfeeding mothers must consult a doctor before taking the medication.

This medicine is approved for combination use in the eradication of H. pylori in patients with active duodenal ulcer. The most common side effects associated with Omeprazole include diarrhea, gas, vomiting, headache, nausea and stomach aches.

Although rare, certain severe adverse reactions are increased possibility of bone fractures, decreased magnesium levels inside the body, seizures, irregular heart-beats, jitteriness, muscle spasms and weakness, feet/hand spasms, voice box spasms, etc.

The likelihood of these severe side effects goes up if you take this medicine for over a period of 3 months. Also, prolonged intake of this medication (usually over a period of three years) can result in your body’s decreased ability to absorb Vitamin B12.

Other possible (albeit rare) side effects include diarrhea, inflammation of the intestine and the stomach lining, damage to the kidneys, allergic reactions, weight loss, and fever.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Erosive Esophagitis

• Gastroesophageal Reflux Disease

• Helicobacter Pylori Infection

• Zollinger-Ellison Syndrome

• Other Forms Of Ulcers

• Heartburn

• Acidity

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Allergy

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Abdominal Pain

• Fever

• Joint Pain

• Sore Throat

• Loss Of Appetite

• Constipation

• Diarrhoea

• Difficulty In Breathing

• Dizziness

• Muscle Pain

• Drowsiness

• Rash

• Back Pain

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• How long is the duration of effect?

  The effect of this medicine lasts for a duration of about 16-18 hours.

• What is the onset of action?

  The effect of this medicine is observed in 1 hour of administration.

• Are there any pregnancy warnings?

  This medicine cannot be used by pregnant women unless necessary. Consult your doctor before taking this medicine.

• Is it habit forming?

  No habit forming tendencies has been reported.

• Are there any breast-feeding warnings?

  This medicine is not suggested for use by breastfeeding women as it may cause some side effects in the infant.

• Is It safe with alcohol?

  Caution must be taken. Avoid consuming alcohol along with this medicine.

• Is it safe to drive while on this medicine?

  It is unknown whether this medicine alter the ability of patients driving skills. It patient experience any side effects, he must avoid driving.

• Does this affect kidney function?

  It is safe to use Esomeprazole in patients with kidney disease.

• Does this affect liver function?

  Caution must be taken in patients with liver disease. Adjustment of dose is needed, kindly consult your doctor before taking this medication.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• Missed Dose instructions

  The missed dose should be taken as soon as possible. The missed dose should be skipped if it is time for the next dose.

• Are there any overdose instructions?

  Contact your doctor if symptoms of overdose such as confusion, drowsiness, blurred vision, dry mouth and headache are suspected.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

Below is the list of medicines, which contains Esomeprazole as ingredient

• Sompraz D 40 Capsule Sr

  Sun Pharmaceutical Industries Ltd

• Sompraz 40 MG Tablet

  Sun Pharma Laboratories Ltd

• Esokem 40 MG Tablet

  Alkem Laboratories Ltd

• Raciper 20 MG Tablet

  Ranbaxy Laboratories Ltd

• S Omepren 20 MG Tablet

  Blue Cross Laboratories Ltd

• Espra 20 MG Tablet

  Zydus Cadila

• Esofag 40 MG Tablet

  Micro Labs Ltd

• Esomac 10 MG Granules

  Cipla Ltd

• Raciper 40 MG Tablet

  Ranbaxy Laboratories Ltd

• Esoz 40 MG Tablet

  Glenmark Pharmaceuticals Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

This medication belongs to the class of proton pump inhibitor drug and binds to H+/K+-exchanging ATPase in gastric parietal cells, resulting in blockage of acid secretion.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Interaction with alcohol is not known. Consult your doctor before consumption.

• Interaction with Lab Test

  Neuroendocrine tumor diagnosis

  This medication should not be used while undergoing the neuroendocrine/carcinoid tumor test as it might give a false-positive result for this diagnostic test.

• Interaction with Medicine

  Clopidogrel

  Report the use of either of the medicine to the doctor. Your doctor may prescribe a safer alternative for reducing the stomach acidity while you are being treated with Clopidogrel.

  Ketoconazole

  This medication should be used with Ketoconazole or other antifungals of the same group with caution. Inform the doctor about the usage of either of these medications so that safer alternatives can be prescribed.

  Methotrexate

  This medication should not be used with Methotrexate. The use of either of the drugs should be reported to the doctor so that a safer substitute could be prescribed.

  Warfarin

  Usage of this medication with Warfarin should be strictly monitored by the doctor. Suitable adjustment in dosage and monitoring of Prothrombin time is necessary to ensure safety. Any symptoms like unusual bleeding, swelling, vomiting, or presence of blood in urine should be reported immediately.

  Nelfinavir

  This medication is not recommended for use when the patient is already taking anti-viral medications like Nelfinavir or other drugs used in the management of HIV Infection.

  Digoxin

  This medication should be used with caution if the patient is on Digoxin. Prior usage of any of these drugs should be informed to the doctor. Any symptoms like nausea, vomiting, diarrhea, loss of appetite, disturbances in vision, and abnormalities in heartbeat should be reported immediately.

• Interaction with Disease

  Liver Disease

  Any history of liver disease has to be reported to the doctor. Suitable dose adjustment is required based on the extent of the liver impairment.

  Osteoporosis

  Suitable dose adjustment have to be made in patients who suffer from Osteoporosis related fracture.

  Hypomagnesemia

  Inform your doctor about magnesium level imbalance in the body. Regular monitoring is advised for patients taking Esomeprazole in such cases.

• Ques : What is Esomeprazole?

  Ans : This medication is used in the treatment of conditions caused by excessive production of acid in the stomach.

• Ques : How long do I need to use Esomeprazole before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use Esomeprazole?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Esomeprazole empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : What are the instructions for the storage and disposal of Esomeprazole?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Ques : What is the half-life of Esomeprazole?

  Ans : The half-life of Esomeprazole is between 1 to 1.5 hours.

• Ques : Does Esomeprazole induce diarrhea?

  Ans : Esomeprazole may cause diarrhea in some patients, however, it should improve in some time.

• Ques : Does Esomeprazole makes the body susceptible to infections?

  Ans : The excessive usage of Esomeprazole makes the body susceptible to bacterial infection, thus, it should be used with caution.

• Ques : What are the dietary specifications while taking Esomeprazole?

  Ans : There are no specific dietary guidelines unless the doctor instructs otherwise.

• Ques : What is the route of administration of Esomeprazole?

  Ans : Esomeprazole is administered orally with a glass of water.

• Esomeprazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 25 Nov 2021]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/esomeprazole

• ESOMEPRAZOLE- esomeprazole magnesium tablet- Daily Med [Internet]. dailymed.nlm.nih.gov. 2021 [Cited 24 Nov 2021]. Available from:

  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ea9ef7b0-7397-470f-b852-397e8b0e66e4

• Esomeprazole 20 mg Gastro-resistant Tablets- EMC [Internet]. www.medicines.org.uk. 2021 [Cited 3 December 2021]. Available from:

  https://www.medicines.org.uk/emc/product/10557/smpc

• Esomeprazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 25 Nov 2021]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/esomeprazole

• ESOMEPRAZOLE- esomeprazole magnesium tablet- Daily Med [Internet]. dailymed.nlm.nih.gov. 2021 [Cited 24 Nov 2021]. Available from:

  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ea9ef7b0-7397-470f-b852-397e8b0e66e4

• Esomeprazole 40 mg gastro-resistant capsules, hard- EMC [Internet]. www.medicines.org.uk. 2021 [Cited 3 December 2021]. Available from:

  https://www.medicines.org.uk/emc/product/12020/smpc