Fluconazole 200 MG Tablet

Fluconazole 200 MG Tablet is primarily prescribed for the treatment of hepatosplenic candidiasis and other Candida infections, cryptococcal infections and secondary prophylaxis for cryptococcal meningitis in persons with AIDS. It is also used as antifungal prophylaxis in allogeneic bone marrow transplant recipients.

This medicine belongs to the class of triazole antifungal. Fluconazole 200 MG Tablet is effectively used in the treatment of meningitis. It affects the membranes in the brain and spinal cord. This drug treats fungal infections like yeast infections in the mouth, throat, food pipe, lungs, vagina, etc.

It works by decreasing the production of ergosterol, which inhibits cell membrane formation in fungi. This drug is also preferred as a preventive medication in patients susceptible to fungal infections while undergoing chemotherapy or radiation therapy before bone marrow transplantation.

Some serious side effects that may occur and need immediate medical attention are:

• Yellowing of the skin, dark urine, light-coloured stool and itchiness of the skin, indicating liver damage
• Severe rash or peeling of the skin in patients suffering from cancer or AIDS
• Irregular or fast heart rate, palpitations, seizures or fainting, indicating Torsades de Pointes (a condition of abnormal rhythm of the heart which may cause a sudden cardiac arrest)

Take as directed, around-the-clock. Take full course of medication as ordered. Follow good hygiene measures to prevent reinfection. Frequent blood tests may be required. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake).

Symptoms of overdose include decreased lacrimation, salivation, respiration and motility, urinary incontinence, cyanosis. Treatment includes supportive measures, a 3-hour hemodialysis will remove 50%.

• Oropharyngeal Candidiasis

• Esophageal Candidiasis

• Cryptococcal Meningitis

• Vaginal Candidiasis

• Urinary Tract Infection

• Peritonitis

• Candidemia

• Prophylaxis Of Infections In Special Population

• Fungal Infections (Tinea Strains)

• Allergy

• QT Interval prolonging drugs

• Nausea Or Vomiting

• Abdominal Pain

• Diarrhoea

• Skin Rash

• Headache

• Dizziness

• Hypokalemia

• Vertigo

• Tremor

• Insomnia

• Decreased Appetite

• How long is the duration of effect?

  The time interval upto which it is effective is more then a day. i.e. 30 hours.

• What is the onset of action?

  The repercussions of this medicine will be visible within 1 to 2 hours after consuming it.

• Are there any pregnancy warnings?

  This medicine is not recommended for use in pregnant women as there are chances of adverse effects on the developing fetus. However, it can be used in some cases when other alternatives have failed.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  This medicine is acceptable for use in a nursing mother. It can be used in treating certain specific infections only after consulting your doctor.

• Does this affect kidney function?

  Dose adjustment is needed in patients with renal impairment. Consult your doctor before taking Fluconazole 200 MG Tablet.

• Does this affect liver function?

  No relevant information available. Consult your doctor before taking Fluconazole 200 MG Tablet.

• Is It safe with alcohol?

  Caution is advised in consuming alcohol, if you are taking this medicine. Please consult your doctor.

• Is it safe to drive while on this medicine?

  This medicine causes side effects that affect the alertness of the patients. Thus it influences the driving ability of the patient.

Below is the list of medicines, which have the same composition, strength and form as Fluconazole 200 MG Tablet , and hence can be used as its substitute.

• Flunova 200 MG Tablet

  Zuventus Healthcare Ltd

• Nuforce 200 MG Tablet

  Mankind Pharmaceuticals Ltd

• Zocon 200 MG Tablet

  Fdc Ltd

• Flustan 200 MG Tablet

  Dr. Reddys Laboratories Ltd

• Fcn 200 MG Tablet

  Intas Pharmaceuticals Ltd

• Are there any missed dose instructions?

  The missed dose can be taken as soon as you remember. If it is time for the next dosage then the missed dose can be skipped.

• Are there any overdose instructions?

  Inform your doctor immediately if you are experiencing symptoms of overdose.

This medication decreases ergosterol production by disrupting the activity of cytochrome P450, inhibiting the formation of the cell membrane of susceptible fungi like Candida and Microsporum.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Lab Test

  Keep monitoring periodic liver function tests (AST, ALT, alkaline phosphatase) and renal function tests, potassium. As these might drastically be affected by the action of the Fluconazole.

• Interaction with Medicine

  • CYP2C9 enzyme inducer; CYP2C9, 2C18, and 2C19 enzyme inhibitor and CYP3A3/4 enzyme inhibitor (weak).
  • Increased effect/toxicity:
  • Coadministration with terfenadine or cisapride is contraindicated; use with caution with astemizole due to increased risk of significant cardiotoxicity.
  • Hydrochlorothiazide may decrease fluconazole clearance.
  • Fluconazole may also inhibit warfarin, phenytoin, cyclosporine, and theophylline, zidovudine, sulfonylureas, rifabutin, and warfarin clearance.
  • Nephrotoxicity of tacrolimus may be increased.
  • Should be used with caution in patients receiving cisapride or astemizole

• Interaction with Disease

  Should be used with caution in patients with renal and hepatic dysfunction or previous hepatotoxicity from other azole derivatives. Patients who develop abnormal liver function tests during fluconazole therapy should be monitored closely and discontinued if symptoms consistent with liver disease develop

• Interaction with Food

  No data reported

• Ques : What is Fluconazole 200 MG Tablet?

  Ans : This is a medication which has Fluconazole as an active ingredient present. It performs its action by avoiding the formation of an enzyme which is necessary for the synthesis of the fungal cell wall.

• Ques : What are the uses of Fluconazole 200 MG Tablet?

  Ans : This is a medication, which is used for the treatment and prevention from conditions such as Oropharyngeal Candidiasis, Esophageal Candidiasis, Cryptococcal Meningitis, Vaginal Candidiasis, Urinary Tract Infection, etc.

• Ques : What are the Side Effects of Fluconazole 200 MG Tablet?

  Ans : This is a medication which has some commonly reported side effects such as Headache, Nausea and Vomiting, Abdominal pain, Diarrhea, Skin rash, QT Prolongation, Alopecia, Seizures, and Swelling of face, lips, eyelids, etc.

• Ques : What are the instructions for storage and disposal Fluconazole 200 MG Tablet?

  Ans : Store this medication in a cool dry place and keep it in the original pack or container until it is time to take them. Store this medication out of sight and reach of children. Unused medicines should be disposed of in special ways to ensure that pets, children and other people cannot consume them.

• Ques : How long do I need to use Fluconazole 200 MG Tablet before I see improvement of my conditions?

  Ans : This is a medicine which takes 1 or 2 days before you see an improvement in your health conditions. It would be ideal if you note, it doesn't mean you will begin to notice such health improvement in a similar time span as different patients.

• Ques : What are the contraindications to Fluconazole 200 MG Tablet?

  Ans : Contraindication to Fluconazole. In addition, this medication should not be used if you have the following conditions such as an allergy to Fluconazole.

• Ques : Is Fluconazole 200 MG Tablet safe to use when pregnant?

  Ans : This medication is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

• Ques : Will Fluconazole 200 MG Tablet be more effective if taken in more than the recommended dose?

  Ans : No, taking higher than the recommended dose of Fluconazole can lead to increased chances of side effects such as abdominal pain, diarrhea, headache, indigestion, nausea, rash, vomiting, etc.

• FLUCONAZOLE - fluconazole tablet- Daily Med [Internet]. dailymed.nlm.nih.gov. 2019 [Cited 26 April 2019]. Available from:

  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5590e3fc-b9a1-4863-9420-900bf437a3cc

• Fluconazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 26 April 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/fluconazole

• Fluconazole- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 23 May 2019]. Available from:

  https://www.drugbank.ca/drugs/DB00196