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Overview

Macrozide 500 MG Tablet

Manufacturer :  Macleods Pharmaceuticals Pvt.Ltd
Medicine Composition :  Pyrazinamide
Prescription vs OTC : Prescription by Doctor required

About Macrozide 500 MG Tablet

Macrozide 500 MG Tablet is an anti-tubercular medicine, which is used alongside other medicines to treat tuberculosis. It also prevents the infection from spreading. If you notice some unwanted effects like a fever, tenderness in the abdomen, jaundice, nausea, vomiting or lack of appetite inform your doctor immediately.

This medicine is not recommended during pregnancy or breastfeeding unless absolutely necessary. Consult your doctor about the potential risks and benefits before starting your treatment with this medicine.

If you suffer from the medical conditions mentioned here, inform your doctor so extra care can be taken during the treatment:

  • pregnant or breast-feeding.
  • kidney or liver problems, alcoholism, acute gout, diabetes or porphyria.
  • If you are taking any other medicines including those which are available without a prescription as well as herbal and complementary medicines.
  • Allergic to any medicine.

This medicine will be prescribed to you and you will be asked to take it three times a week during the first two months of your treatment under the supervision of a healthcare provider. Taking the tablets regularly and on time is very important.

It is also important to complete the course of treatment so that there are no chances of the infection to come back. The effect of this medicine can be observed within the first 2 hours of taking it and lasts for an average duration of 27 to 30 hours.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    What are the uses of Macrozide 500 MG Tablet

    • Tuberculosis

      This medication is used in the treatment of tuberculosis which is a lung disease caused by Mycobacterium tuberculosis.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    What are the contraindications of Macrozide 500 MG Tablet ?

    • Allergy

      Not recommended in patients with known allergy to this medication.

    • Severe Liver Impairment

      Not recommended in the patients with severe liver impairment.

    • Acute Gout

      Not recommended in patients with increased uric acid levels or acute gout.

    • Porphyria

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    What are the side effects of Macrozide 500 MG Tablet ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    Key highlights of Macrozide 500 MG Tablet

    • How long is the duration of effect?

      The effect of this medicine lasts for an average duration of 27 to 30 hours.

    • What is the onset of action?

      The effect of this medicine can be observed in 2 hours.

    • Are there any pregnancy warnings?

      This medicine is not recommended for use during pregnancy unless absolutely necessary.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Are there any breast-feeding warnings?

      This medicine is excreted in breast milk. It is recommended for breastfeeding women only if clearly needed.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    What are the substitutes for Macrozide 500 MG Tablet ?

    Below is the list of medicines, which have the same composition, strength and form as Macrozide 500 MG Tablet , and hence can be used as its substitute.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    What are the dosage instructions?

    • Missed Dose instructions

      If you miss a dose of medication, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

    • Are there any overdose instructions?

      Seek emergency medical treatment or contact the doctor in case of an overdose.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    Where is the Macrozide 500 MG Tablet approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    How does this medication work?

    This medicine belongs to an antitubercular class of drugs. It works by inhibiting the growth of the organism by decreasing the pH inside the cell by converting it into an active metabolite called pyrazinoic acid in the presence of pyrazinamidase.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

      What are the interactions of Macrozide 500 MG Tablet ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

        test
      • Interaction with Alcohol

        Alcohol

        Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
      • Interaction with Medicine

        Methotrexate

        These medicines may increase the risk of liver injury. Inform the doctor if you are receiving these medicines. The baseline of liver function tests should be obtained before starting the treatment. Any signs and symptoms of elevated liver enzymes, yellow colored eyes, and skin, dark urine should be reported to the doctor.

        Cholera Vaccine

        If you have taken this medication, then it is advisable to wait for 14 days before taking the Cholera vaccine. Usage of other antibiotics and vaccines should be reported to the doctor.
      • Interaction with Disease

        Gout

        This medicine is not recommended in patients with gout. Inform the doctor about your medical condition. Serum uric acid levels should be monitored carefully. Discontinue the treatment if the symptoms persist.
      • Interaction with Food

        Food

        Information not available.

      FAQs about Macrozide 500 MG Tablet

      • Ques : What is Macrozide 500 MG Tablet?

        Ans : is an anti-tuberculosis medicine which is used alongside other medicines to treat tuberculosis.

      • Ques : How long do I need to use Macrozide 500 MG Tablet before I see improvement in my condition?

        Ans : This medication is to be taken till the time you see an improvement in your health conditions.

      • Ques : At what frequency do I need to use Macrozide 500 MG Tablet?

        Ans : This medication will be prescribed to you and you will be asked to take it three times a week, during the first two months of your treatment

      • Ques : Should I use Macrozide 500 MG Tablet empty stomach, before food or after food?

        Ans : This medication should be taken after food in a prescribed dosage.

      • Ques : What are the instructions for the storage and disposal of Macrozide 500 MG Tablet?

        Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

      References

      • Pyrazinamide- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 11 December 2019]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/pyrazinamide

      • Pyrazinamide- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 11 December 2019]. Available from:

        https://www.drugbank.ca/drugs/DB00339

      • Zinamide 500mg Tablets- EMC [Internet] medicines.org.uk. 2015 [Cited 11 December 2019]. Available from:

        https://www.medicines.org.uk/emc/product/5273/smpc

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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