Metograf 50 MG Tablet

The primary use of Metograf 50 MG Tablet is to treat hypertension and angina pectoris. It is also prescribed as a preventive measure to treat myocardial infarction, atrial fibrillation, flutter, and symptomatic treatment of hypertrophic subaortic stenosis.

Metograf 50 MG Tablet is prescribed to patients to improve heart function and control blood flow through the vessels. The drug helps in the treatment of hypertension, that is, high blood pressure and angina, that is, chest pain.

Metograf 50 MG Tablet effectively blocks the action of a few body chemicals that occur naturally in the body. The medicine can be taken either before or after a meal. The dosage of the drug depends on the severity of the condition. The doctor may increase dosage as per requirement.

Over dosage of Metograf 50 MG Tablet should be avoided. In case of accidental overdosage emergency medical care should be acquired. Patients with certain medical problems are generally not advised to take this drug. The medicine is not recommended for patients who have coronary heart disease or blood circulation issues.

If you have suffered a heart attack recently Metograf 50 MG Tablet may not be the best option for you. Inform your doctor before consuming the drug, if you have clinical conditions like-

• Kidney issues
• Liver problems
• Thyroid disorder
• Any allergies.

Because Metograf 50 MG Tablet leads to confusion, one should avoid driving in order to avoid accidents. Alcohol should also be avoided when on the drug because liquor can intensify its side effects. The dosage of Metograf 50 MG Tablet may vary from 100mg to 450mg.

Some medicines which may affect the action of Metograf 50 MG Tablet are prazosin, terbinafine, bupropion etc. Thus, you should inform your doctor about any medicines that you are currently taking before starting the medicine. In case of a missed drug dose, it should be taken as soon as possible. However, avoid taking the missed dose along with the next dose as it may lead to complications.

Symptoms of intoxication include cardiac disturbances, CNS toxicity, bronchospasm, hypoglycemia and hyperkalemia. The most common cardiac symptoms include hypotension and bradycardia; atrioventricular block, intraventricular conduction disturbances, cardiogenic shock, and asystole may occur with severe overdose, especially with membrane-depressant drugs (eg, propranolol); CNS effects include convulsions, coma, and respiratory arrest.

Treatment includes symptomatic treatment of seizures, hypotension, hyperkalemia and hypoglycemia; bradycardia and hypotension resistant to atropine, isoproterenol or pacing, may respond to glucagon; wide QRS defects caused by the membrane-depressant poisoning may respond to hypertonic sodium bicarbonate; repeat-dose charcoal, hemoperfusion, or hemodialysis may be helpful in removal of only those beta-blockers with a small Vd, long half-life or low intrinsic clearance (acebutolol, atenolol, nadolol, sotalol).

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Hypertension

• Angina Pectoris

• Heart Attack

• Congestive Heart Failure (Chf)

• Hyperthyroidism

• Migraine Prevention

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Allergy

• Heart Diseases

• Circulatory Disorders

• Heart Failure

• Heart Rhythm Disorders

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Drowsiness

• Insomnia

• Decreased Sexual Urge

• Bradycardia

• Palpitations

• Edema (Swelling)

• Congestive Heart Failure

• Depression

• Nausea

• Vomiting

• Stomach Discomfort

• Bronchospasm

• Cold Extremities

• Chest Pain

• Nervousness

• Headache

• Orthostatic Hypotension

• Confusion

• Thrombocytopenia

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• How long is the duration of effect?

  The effect lasts for 3 to 6 hours upon oral administration. This increases to 5 to 6 hours upon intravenous infusion.

• What is the onset of action?

  The effect of Metoprolol (primary constituent of Metograf 50 MG Tablet) can be observed within an hour of oral administration. When given in the form of an intravenous infusion, the action starts in 20 minutes.

• Are there any pregnancy warnings?

  This medicine is not recommended for use during pregnancy unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine. Even if the medicine is used, the dose should be as low as possible and should be discontinued at least 2-3 days before delivery.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  This medicine has not known to cause any alarming side effects on the infant as the amount passed through milk is very less. However, caution should be exercised and the medicine be used only when the potential benefits outweigh the risks associated. Consult your doctor before taking this medicine.

• Is It safe with alcohol?

  This medicine is found to be unsafe if consumed with alcohol.

• Is it safe to drive while on this medicine?

  This medicine affects the consciousness of the patient and also the alertness of the patient. Do not drive if you are taking this medicine.

• Does this affect kidney function?

  This medicine is found to be safe if used in patients with kidney disease. Adjustment of dose is not needed.

• Does this affect liver function?

  Caution must be taken in patients with liver disease. A reduced dose is probably necessary. Kindly consult your doctor before taking this medicine.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

Below is the list of medicines, which have the same composition, strength and form as Metograf 50 MG Tablet , and hence can be used as its substitute.

• Xmbeta 50 MG Tablet

  Macleods Pharmaceuticals Pvt.Ltd

• Betaloc 50 MG Tablet

  Astrazeneca Pharma India Ltd

• Metolar 50 MG Tablet

  Cipla Ltd

• Actiblok Ipr 50 MG Tablet

  Biocon Ltd

• Sitelol 50 MG Tablet XR

  Sanofi India Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Are there any missed dose instructions?

  Take the missed dose as soon as you remember. However, the missed dose can be skipped if it is almost time for the next scheduled dose.

• Are there any overdose instructions?

  An overdose of this medication can cause some serious effects on the heart, blood vessels, and nerve conduction. Report the incidence as soon as possible so that medical intervention can begin. Supportive measures like Gastric lavage and symptomatic treatment might be required based on severity.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

This medication works by blocking the beta receptors sites in the heart, blood vessels, and lungs. This results in inhibition of epinephrine resulting in relaxed blood vessels. Thus pressure is lowered and blood flow to the heart is improved.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Use of alcohol should be avoided while taking Metograf 50 MG Tablet especially when you start taking the medicine or a change its dosage. Symptoms like headache, dizziness, change in pulse or heart rate should be reported to the doctor.

• Interaction with Lab Test

  Information not available.

• Interaction with Medicine

  Amlodipine

  Report the usage of either of these medicines to the doctor. A dose adjustment and safety monitoring may be required in such cases. Symptoms like headache, fainting, decrease in pulse or heart rate should be reported to the doctor.

  Diltiazem

  Report the use of either of these medicines to the doctor. Dose adjustment and safety monitoring may be required in such cases. Symptoms like fatigue, headache, fainting, an increase in weight, chest pain should be reported to the doctor.

  Aminophylline

  Report the usage of either of these medicines to the doctor. Dose adjustments and safety monitoring may be required in such cases. Contact your doctor if you experience nausea, vomiting, lack of sleep, and uneven heartbeat. Do not discontinue the usage of any medicine without consulting your doctor.

  Ergotamine

  Report the use of either of these medicines to the doctor. A dose adjustment and safety monitoring may be required in such cases. Symptoms like cold and numb hands and feet, muscle pain and weakness, severe headache etc. should be reported to the doctor.

  Others

  This medicine must not be concomitantly used along with the following:

  • CYP2D6 enzyme substrate
  • Clonidine:Hypertensive crisis after or during withdrawal of either agent.
  • Drugs which slow AV conduction (digoxin): effects may be additive with beta-blockers.
  • Fluoxetine may inhibit the metabolism of Metograf 50 MG Tablet resulting in cardiac toxicity.
  • Glucagon: Metograf 50 MG Tabletmay blunt the hyperglycemic action of glucagon.
  • Hydralazine may enhance the bioavailability of Metograf 50 MG Tablet.
  • Insulin and oral hypoglycemics: Metograf 50 MG Tablet may mask tachycardia from hypoglycemia.
  • Metograf 50 MG Tablet reduces antipyrine's clearance by 18%.
  • NSAIDs (ibuprofen, indomethacin, naproxen, piroxicam) may reduce the antihypertensive effects of beta-blockers.
  • Oral contraceptives may increase the AUC and Cmax of Metograf 50 MG Tablet.
  • Salicylates may reduce the antihypertensive effects of beta-blockers.
  • Sulfonylureas: Beta-blockers may alter response to hypoglycemic agents.
  • Verapamil or diltiazem may have synergistic or additive pharmacological effects when taken concurrently with beta-blockers; avoid concurrent I.V. use.

• Interaction with Disease

  Asthma

  Metograf 50 MG Tablet should not be used in patients suffering from bronchial asthma or Chronic Obstructive Pulmonary Disease. Report the incidence of Asthma to your doctor so that Metograf 50 MG Tablet can be substituted with another medication.

  Heart Block

  Metograf 50 MG Tablet should not be used in patients having a heart block greater than first degree. However, it can be used in this case if a pacemaker is present to correct the disorder.

  Diabetes

  Metograf 50 MG Tablet should be administered with caution in patients suffering from diabetes or a condition where blood sugar level is likely to get low. You should consult a doctor if any symptom indicating a lowered blood sugar level is suspected while using this medicine.

  Liver Disease

  Metograf 50 MG Tablet should be administered with caution in patients having a liver disease. Suitable dose adjustment and safety monitoring are advised in such cases.

  Glaucoma

  Metograf 50 MG Tablet should be administered with caution in a patient suffering from Glaucoma. A change in the dose of current Glaucoma medicine may be required. In some cases, your doctor may advise the use of another medicine in place of a beta blocker.

  High Cholesterol And Fat

  Metograf 50 MG Tablet should be administered with caution in a patient having high levels of cholesterol and fats in their body. Suitable dose adjustment and safety monitoring may be required in such cases.

• Interaction with Food

  Metograf 50 MG Tablet should be used with caution if you are taking vitamin and mineral supplement. Report the usage of supplements to the doctor so that dose adjustments and safety monitoring can be done. There should be a gap of at least 2 hours between the consumption of these two medicines.

• Ques : Does Metograf 50 MG Tablet cause weight gain?

  Ans : Yes, Metograf 50 MG Tablet can cause weight gain. Please consult your doctor if you experience weight gain with this medication as it could be due to some underlying condition that needs attention.

• Ques : How long does Metograf 50 MG Tablet take to work?

  Ans : The time taken by this drug to start working varies from person to person. Usually, it starts working within 15 minutes. However, in some patients, it may take up to 2 hours to start showing its beneficial effects.

• Ques : Is there any food or drink I need to avoid while taking Metograf 50 MG Tablet?

  Ans : You can eat and drink normally while taking Metograf 50 MG Tablet. However, making lifestyle changes like stopping smoking, eating healthy food, and exercising regularly can further give a boost to your health.

• Ques : Do I need to avoid playing sports while taking Metograf 50 MG Tablet?

  Ans : No, there is no need to quit playing sports while taking this medication. In fact, regular exercise can help you in controlling your blood pressure. However, it is advised not to overdo any physical activity or push yourself too hard while exercising or playing sports.

• Ques : Does Metograf 50 MG Tablet cause weight gain?

  Ans : Yes, Metograf 50 MG Tablet can cause weight gain. Please consult your doctor if you experience weight gain with this medication as it could be due to some underlying condition that needs attention.

• Ques : How long does Metograf 50 MG Tablet take to work?

  Ans : The time taken by this drug to start working varies from person to person. Usually, it starts working within 15 minutes. However, in some patients, it may take up to 2 hours to start showing its beneficial effects.

• Ques : Is there any food or drink I need to avoid while taking Metograf 50 MG Tablet?

  Ans : You can eat and drink normally while taking Metograf 50 MG Tablet. However, making lifestyle changes like stopping smoking, eating healthy food, and exercising regularly can further give a boost to your health.

• Ques : Do I need to avoid playing sports while taking Metograf 50 MG Tablet?

  Ans : No, there is no need to quit playing sports while taking this medication. In fact, regular exercise can help you in controlling your blood pressure. However, it is advised not to overdo any physical activity or push yourself too hard while exercising or playing sports.

• Metoprolol- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 3 December 2021]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/metoprolol

• METOPROLOL SUCCINATE- metoprolol succinate tablet, film coated, extended release- Daily Med [Internet]. dailymed.nlm.nih.gov. 2021 [Cited 24 Nov 2021]. Available from:

  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=74a28333-53c1-493e-b6ad-2192fdc35391

• Metoprolol Tartrate 50 mg tablets- EMC [Internet]. www.medicines.org.uk. 2019 [Cited 24 Nov 2021]. Available from:

  https://www.medicines.org.uk/emc/product/5345/smpc