Metrogyl 400 MG Tablet

Metrogyl 400 MG Tablet is prescribed for the treatment of amebiasis, symptomatic and asymptomatic trichomoniasis, skin and skin structure infections, CNS infections, intra-abdominal infections and systemic anaerobic infections.

It is used in combination with other agents (eg, tetracycline, bismuth subssalicylate and an H2-antagonist) to treat duodenal ulcer disease due to helicobacter pylori. Metrogyl 400 MG Tablet is also used in Crohn's disease and hepatic encephalopathy.

Developed by JB Chemicals, Metrogyl comprises of Metronidazole which is antibacterial and antifungal. It is used in the treatment of bacterial as well as a fungal infection. A prescription is required for this drug. The drug is an anti-protozoal used either on its own or in combination in the treatment of infections in the stomach and genital areas. Its course of action is entering into an organism and forming a free radical.

The alteration in the molecule which promotes the influx of the molecule creates a concentration gradient which will ultimately interfere with the DNA synthesis of the molecule and inhibit the growth of the organism.

Metrogyl is used as a sole medicine or in a combination with other medicines for the treatment of inflammatory diseases, dracunculiasis, giardiasis, endocarditis, and trichomoniasis. It is used only for certain bacterial and parasitic infections of the respiratory tract, vagina, skin, and joints.

It is also used to ward off any infections that occur before or after the operations of the intestines and helps in decreasing the onset of infections contracted after surgical procedures in patients which are experiencing elective disorders of the anus, colon, and rectum.

The medication is prescribed in the treatment of Amebiasis, Trichomoniasis, Bacterial Vaginosis, Bacterial infections and Surgical prophylaxis. This medication is not recommended with alcohol as it can cause severe discomfort and reactions.

This medication may have a lot of side effects and I should be taken under medical prescription some side effects include agitation, blurred vision, burning or tingling sensation of hands and feet, fevers and chills, skin rash, vaginal irritation, loss of appetite, constipation, yellow coloured eyes or skin and abdominal pain.

If the medication is taken while there is alcohol present in the system it can cause palpation, warmth, headache and breathing difficulty. This medication does not cause habit-forming tendencies. This drug is not recommended for women who just got pregnant but can be used in the later term of pregnancy.

Breastfeeding mothers should avoid this drug as it can be passed down through milk and cause severe indigestion or diarrhoea. This medication may lower blood count and convulsions.

Use Metrogyl 400 MG Tablet with caution in patients with liver impairment due to potential accumulation, blood dyscrasias; a history of seizures, congestive heart failure, or other sodium retaining states; reduce dosage in patients with severe liver impairment, CNS disease, and severe renal failure (Clcr <10 mL/minute).

If H. pylori is not eradicated in patients being treated with Metrogyl 400 MG Tablet in a regimen, it should be assumed that metronidazole-resistance has occurred and it should not again be used; seizures and neuropathies have been reported especially with increased doses and chronic treatment; if this occurs, discontinue therapy.

• Bacterial Infections

• Parasitic Infections

• Amebiasis

• Trichomoniasis

• Bacterial Vaginosis

• Surgical Prophylaxis

• Giardiasis

• Peptic Ulcer

• Allergy

  Hypersensitivity to Metrogyl 400 MG Tablet or any related component.

• Pregnancy

  Metrogyl 400 MG Tablet is contraindicated in 1st trimester of pregnancy since found to be carcinogenic in rats.

• Dizziness

• Headache

• Nausea

• Diarrhoea

• Seizures

• Metallic Taste

• Anorexia

• Abdominal Pain

• Peripheral Neuropathy

• How long is the duration of effect?

  The effect of Metrogyl which is used for treating bacterial infections last for an average of 24 hours after consumption.

• What is the onset of action?

  Within 1-2 hours after consumption, the peak effects of the medicine are observed.

• Are there any pregnancy warnings?

  Pregnant women should not use this medication before using this drug.

• Is it habit forming?

  Metrogyl doesn’t have any habit forming tendencies.

• Are there any breast-feeding warnings?

  This medicine is known to excreted through the breastmilk. It is used in breastfeeding women only if clearly needed. Breastfeeding should be avoided for 24 hours after single-dose maternal treatment. Monitoring of candidal infections and diarrhea is necessary.

• Is It safe with alcohol?

  No, this medication should not be taken while under the influence of alcohol as there can be an adverse side effect and major health complications.

• Is it safe to drive while on this medicine?

  Metrogyl can cause drowsiness in the patient, which can be very dangerous while driving. The patient must refrain from performing any activity that requires alertness in the patient.

• Does this affect kidney function?

  For patients suffering from any kidney abnormalities, the consumption of Metrogyl can cause kidney disorders such as kidney failure. Consulting the doctor before consumption is a prudent idea.

• Does this affect liver function?

  The medication is know to cause liver injury and liver treatment of baseline liver enzymes if you are about to start this medication. Consult your doctor if you want to seek other alternative or want to be on a safer side while under this medication. You should discontinue the treatment if you see the state of your liver deteriorating.

Below is the list of medicines, which have the same composition, strength and form as Metrogyl 400 MG Tablet , and hence can be used as its substitute.

• Aristogyl 400 MG Tablet

  Aristo Pharmaceuticals Pvt.Ltd

• Balgyl 400 MG Tablet

  Micro Labs Ltd

• Flagyl 400 MG Tablet

  Abbott Healthcare Pvt. Ltd

• Metronidazole 400 MG Tablet

  Cadila Pharmaceuticals Ltd

• Metropen 400 MG Tablet

  Pfizer Ltd

• Are there any missed dose instructions?

  If you miss a dose of this drug, take the missed dose as soon as you remember. Do not double your dose to make up for the missed dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

Metronidazole belongs to the class anthelmintics. It enters into the organism and forms the free radical. A concentration gradient is created in the organism due to alteration in the molecule and promotes the influx of the molecule. Thus, the free radical and the altered molecule will interfere with the DNA synthesis and stops the growth of the organism.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

test

• Interaction with Alcohol

  The interaction of Metrogyl with alcohol can cause the reaction of disulfiram in patients during nitroimidazole therapy. The inhibition of aldehyde dehydrogenase (ALDH) is caused. It is highly recommended to not consume alcohol while being treated with Metrogyl.

• Interaction with Lab Test

  Metrogyl 400 MG Tablet may interfere with AST, ALT, triglycerides, glucose, and LDH testing.

• Interaction with Medicine

  The drugs that you should avoid while taking this medication are Warfarin, Ethinyl Estradiol, Atorvastatin and Disulfiram. Consult your doctor if you are under any other medication to avoid unnecessary complications.

• Interaction with Disease

  Metrogyl interacts strongly with disulfiram which is used for the treatment of alcoholism. If the two are taken in combination, the patient may suffer from mental problems. Busulfan is used in the treatment of cancer which can cause adverse effects due to high levels of accumulation in the body.

• Interaction with Food

  Metrogyl is not known to have any reactions with food.

• Ques : What is Metrogyl 400 MG Tablet?

  Ans : Metrogyl belongs to the antiprotozoal class of drugs. It helps in treating infections in the stomach, genital areas. It is not recommended to take alcohol with this medicine. Take this medicine only if it is necessary to reduce the development of resistance.

• Ques : What is Metrogyl 400 MG Tablet used for?

  Ans : Metrogyl is used to treat fungal and bacterial infections.

• Ques : What are the side effects of Metrogyl 400 MG Tablet?

  Ans : Metrogyl can cause a few side effects which include Agitation, Fever and chills, Skin rash, Vaginal irritation and Loss of appetite etc.

• Ques : Can Metrogyl 400 MG Tablet be taken empty stomach?

  Ans : Most of the patients are suggested to take this medicine along with food. Whereas it is not crucial to take it with food and in some cases, patients have taken it empty stomach.

• Ques : Is Metrogyl 400 MG Tablet used for bacterial infections?

  Ans : Yes, metrogyl is used for bacterial infections.

• Ques : How long do i have to take Metrogyl 400 MG Tablet?

  Ans : Usually, Metrogyl should be taken for 7 days. However, dosage of this medication depends on Patient to patient.

• Ques : Can Metrogyl 400 MG Tablet be taken empty stomach?

  Ans : It is advised to take Metrogyl after consuming meals to have better digestion of medication.

• Ques : Can the use of Metrogyl 400 MG Tablet cause metallic taste?

  Ans : Yes. Metrogyl 400 mg tablet can lead to metallic taste.

• Ques : How long do I need to use Metrogyl 400 MG Tablet before I see improvement of my conditions?

  Ans : Metrogyl 400 MG Tablet is a medicine which takes 1 or 2 days before you see an improvement in your health conditions. It would be ideal if you note, it doesn't mean you will begin to notice such health improvement in a similar time span as different patients. There are numerous elements to consider such as, salt interactions, precautions to be taken care of, time is taken by the salt to performs its action, etc. we beg you to visit your doctor to realize to what extent before you can see improvements in your health while at the same time taking Metrogyl 400 MG Tablet.

• Metronidazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 24 April 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/metronidazole

• Flagyl 400mg Tablets- EMC [Internet]. www.medicines.org.uk. 2018 [Cited 24 April 2019]. Available from:

  https://www.medicines.org.uk/emc/product/9238/smpc

• Important information about Metronidazole- Drugs Bank [Internet]. drugsbanks.com. 2017 [Cited 24 April 2019]. Available from:

  https://www.drugsbanks.com/metronidazole/

• METRONIDAZOLE- metronidazole tablet- Daily Med [Internet]. dailymed.nlm.nih.gov. 2006 [Cited 24 April 2019]. Available from:

  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a9987047-9c99-45a5-829b-ae8b189cbfd4