Napra D 250mg Tablet

Napra D 250mg Tablet is a combination medication, primarily prescribed for the treatment and prevention of migraine attack. This medication is comprized of two drugs, Naproxen and Domperidone, which belongs to the class of a non-steroidal anti-inflammatory drugs and dopamine antagonists, respectively.

On using this medicine some side effects like stomach upset, nausea, vomiting, heartburn, drowsiness, headache may occur. Serious side effects may include easy bruising or bleeding, painful swallowing, ringing in the ears, signs of kidney problems, mood changes, unusual tiredness, swelling of the ankles, feet and hands, unexplained stiff neck, unexplained weight gain and vision changes.

To ensure this medicine is safe for you tell your doctor if you have asthma, blood disorders, nasal polyps, liver disease, heart disease, stroke, high blood pressure or throat, stomach or intestinal problems.

Take this medicine by mouth as instructed by your doctor, usually 2 or 3 times in a day. Remember to not lie down for a minimum of 10 minutes after taking it. To prevent stomach upset, take this drug with milk, food or an antacid.

To reduce your risk of side effects, start the medication at the lowest effective dose for a short period of time. Take a higher dosage if needed, after consulting with a doctor.

• Prevention Of Migraine Attacks

• Nausea Or Vomiting

• Hypersensitivity Reaction

• Dry Mouth

• Indigestion

• Flu-Like Symptoms

• Is It safe with alcohol?

  You should not take this drug with alcohol as it has inflammatory effects and it can nullify the effects of this medication in some people.

• Are there any pregnancy warnings?

  This medication is unsafe to use during pregnancy.

• Are there any breast-feeding warnings?

  The amount of drug secreted in milk is too small to be harmful to the infant, and is usually found to be safe in ordinary doses. But the patient must consult before taking it.

• Is it safe to drive while on this medicine?

  You should not drive when you have taken as it can cause drowsiness.

• Does this affect kidney function?

  Patients with impaired kidney functions must exercise caution when taking this medication, as it can make their symptoms worse. Doctors may have to use this medicine in smaller doses.

• Does this affect liver function?

  Patients with impaired liver function must exercise caution when taking this medication, as it can make their symptoms worse. Doctors may have to use this medicine in smaller doses.

• How long is the duration of effect?

  The effects of the medication last for 6-8 hours.

• What is the onset of action?

  This medicine has a fairly quick onset. You will begin to feel its effects within 30-60 minutes.

• Is it habit forming?

  Habit forming tendencies have not been reported for this medicine.

Below is the list of medicines, which have the same composition, strength and form as Napra D 250mg Tablet , and hence can be used as its substitute.

• Minado Tablet

  Tas Med India Pvt Ltd

• Macprox Dp 250 Tablet

  Macleods Pharmaceuticals Pvt Ltd

• Comig 250 Tablet

  Seagull Labs (I) Pvt Ltd

• Pacinac NP 250mg/10mg Tablet

  Gentech Healthcare Pvt Ltd

• Naprodom 250Mg Tablet

  Crescent Therapeutics Ltd

• Xenadom 250 Mg/10 Mg Tablet

  Icon Life Sciences

• Are there any missed dose instructions?

  Missed dose should be taken as soon as possible. It is recommended to skip your missed dose, if it is the time for your next scheduled dose.

• Are there any overdose instructions?

  Consult your doctor in case of overdose.

This medication is a combination of Naproxen and Domperidone. This medicine is prescribed for the treatment of migraine attacks. As both the drugs belong to two different classes, namely, NSAIDs (Non-Steroidal Anti Inflammatory Drug) and Dopamine antagonist, respectively, thus it works via dual mechanism.

Firstly it inhibits prostaglandin synthesis by non selectively impeding the COX -1 and COX -2 enzymes. This helps in alleviating inflammation, as prostaglandin is a regulator for inflammation in muscles. Secondly, it gets attached to the dopaminergic receptors without causing any release of the chemical dopamine. This, in turn, eases gastric emptying and abate small bowel transit time.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Alcohol use is strictly advised against when you are on this medicine. That is because alcohol increases the tendency of your stomach to bleed, which may be a side effect of this medicine. The bleeding is caused due to the chemical naproxen.

• Interaction with Medicine

  It has negative interactions with antacids, amiodarone, Atazanavir, Ciprofloxacin, Clarithromycin, Bisoprolol, aluminium hydroxide and oxide, amprenavir and Aprepitant.

• Interaction with Disease

  This medication should not be consumed in case you have had allergy to it or its active components in the past. It also should not be taken in case you have other diseases like vertigo, active peptic ulcers, kidney diseases and impairment, gastrointestinal and stomach bleeding and congestive heart failure.

• Interaction with Food

  This medicine does not have any known interactions with food items.

• Ques : What is Napra D 250mg Tablet used for?

  Ans : This medication is used to treat migraine. This medication contains domperidone and naproxen as active ingredients. Do not chew or break this medicine, it has to be swallowed as a whole and can be taken with or without food at a fixed time.

• Ques : What are the side effects of Napra D 250mg Tablet?

  Ans :

  Some of the side effects are mentioned below:

  1. drowsiness
  2. headache
  3. depression
  4. itching
  5. inability of concentration
  6. swelling of eyes and lips

• Ques : Is Napra D 250mg Tablet safe during pregnancy?

  Ans : Kindly consult with a doctor or specialist for a recommendation on a particular case.

• Naproxen- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/naproxen

• Naproxen- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB00788

• Domperidone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/domperidone

• Domperidone- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:

  https://www.drugbank.ca/drugs/DB01184