Nuplene-C Gel

Nuplene-C Gel is a combination of two drugs, Adapalene and Clindamycin, primarily used to treat acne vulgaris. These drugs belong to a class of drugs called retinoids and lincosamide (an antibacterial) respectively.

This medicament works by decreasing the formation of blackheads and helps to renew skin faster. It also kills the microorganism responsible for causing acne. It also helps to heal pimples, whiteheads and blackheads on the skin by reducing skin inflammation and swelling.

If you are allergic to any of the ingredients of Nuplene-C Gel, it is not be used. If you suffer from sunburn or eczema, its usage is not advised as well. Alert your doctor if you are allergic to Vitamin A drugs and other retinoid drugs such as isotretinoin.

The medicament is only meant for external use, and should not be applied to abrasions, cuts or sunburned skin. Avoid contact with eyes as it may cause redness and irritation. Nuplene-C Gel may cause your skin to become sunburned easily, so it is advisable to limit your time in the sun.

This medicament may cause some burning and stinging earlier on. Peeling, redness, scaling and dryness of skin may be seen too. Find medical attention immediately if you experience rashes, difficulty in breathing and swelling of face and lips.

• Acne

• Acneiform Eruptions

• Acne Vulgaris

• Allergy

• Skin Peeling

• Skin Redness

• Itching

• Dry Skin

• Burning Sensation

• Is It safe with alcohol?

  No interaction found

• Are there any pregnancy warnings?

  Accare gel may be unsafe to use during pregnancy.
  Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

• Are there any breast-feeding warnings?

  Accare gel is probably safe to use during breastfeeding. Please consult your doctor.

• Is it safe to drive while on this medicine?

  There is no data available. Please consult doctor before consuming the drug.

• Does this affect kidney function?

  There is no data available. Please consult doctor before consuming the drug.

• Does this affect liver function?

  There is no data available. Please consult doctor before consuming the drug.

This medication is a combination of Adapalene and Clindamycin, thus it works following a dual mechanism. Firstly, it works by mechanistically combining with certain retinoic acid nuclear receptors as well as retinoid X receptors. It does not combine with cytosolic receptor protein, however. The exact working nature of this medicine is not known. Secondly, it works by binding to the 50S subunit of the bacterial ribosome thus inhibits the protein synthesis in the bacteria and stops the growth of the bacteria. Thus it inhibits the bacterial growth responsible for causing acne.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

test

• Interaction with Medicine

  null

  This medication interacts with Salicylic Acid, Neuromuscular blockers, Isotretinoin.

• Interaction with Disease

  null

  This medication interacts with eczema, sunburn.

• Ques : What is Nuplene-C Gel?

  Ans : This medication is a combination of Adapalene and Clindamycin. These two drugs belong to the class named retinoid and lincosamide respectively. This medicament is primarily prescribed to treat acne (Nodulocystic or Resistant acne).

• Ques : How long do I need to use Nuplene-C Gel before I see improvement in my condition?

  Ans : In most of the cases, the average time taken by this medication to reach its peak effect is around 1 day to 1 week. Please consult your doctor for the time period you need to use this medication.

• Ques : At what frequency do I need to use Nuplene-C Gel?

  Ans : This medication is generally applied at the affected area at the night. It is advised to consult your doctor before the usage, as the frequency also depends on the patient's condition.

• Ques : Should I use Nuplene-C Gel empty stomach, before food or after food?

  Ans : As this is a medicament to be applied externally. Thus it does not have any relation with the food intake.

• Ques : What are the instructions for the storage and disposal of Nuplene-C Gel?

  Ans : It should be stored at cool dark place, away from heat and direct light. Do not freeze. Keep it away from the reach of children and pets.

• Adapalene- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 31 January 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/adapalene

• Adapalene- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 31 January 2020]. Available from:

  https://www.drugbank.ca/drugs/DB00210

• Clindamycin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 31 January 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/clindamycin

• Clindamycin- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 31 January 2020]. Available from:

  https://www.drugbank.ca/drugs/DB01190