Pretyline 75Mg/10Mg Tablet

Pretyline 75Mg/10Mg Tablet is a combination medication prescribed for the treatment of severe neuropathic pain. It is also used for the management of neuropathic disorders like diabetic peripheral neuropathy, postherpetic neuralgia, and spinal cord injury.

It works by binding to a certain region of the brain and reducing the pain signals sent out by the damaged nerves of the body. This medicine is also utilised for treating restless leg syndrome, epilepsy, shingles, seizures, fibromyalgia and generalised anxiety disorder.

This medication is not recommended for you if you are pregnant, or have an allergic reaction towards any of its ingredients. Some medicines interact with it. Inform your doctor if you are taking any of the following:

• Angiotensin- converting enzyme inhibitors
• Benzodiazepines or narcotic pain medicines
• Thiazolidinedione antidiabetic agents

Ensure your doctor is informed if you have any of the following medical conditions before starting the medication:

• If you have congestive heart failure, irregular heartbeat, diabetes, bleeding problems, muscle problems, highballed pressure or low platelet count.
• If you have improper kidney functioning or are on dialysis.
• If you have a history of angioedema.
• If you are pregnant, planning to be pregnant or are breastfeeding.
• If you take any other medicines, dietary supplements or herbal preparations.
• If you have mental or mood problems, suicidal thoughts, or are dealing with depression.

The dose for this medication may vary according to the age, sex, pathological conditions and other factors. The dosage can later be increased depending on efficacy and tolerability of the patient.

• Neuropathic Pain

• Diabetic Peripheral Neuropathy

• Postherpetic Neuralgia

• Hypersensitivity

• Myocardial Infarction

• Dizziness

• Drowsiness

• Peripheral Edema

• Nausea

• Blurred Vision

• Dry Mouth

• Weight Gain

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 10-12 hours.

• What is the onset of action?

  This medicine has a varying onset time depending on the intended use.

• Are there any pregnancy warnings?

  Use of this medicine during pregnancy is not recommended unless absolutely necessary.

• Is it habit forming?

  This medicine has a low abuse potential with limited physical and psychological dependence.

• Are there any breast-feeding warnings?

  The use of this medicine by breastfeeding women is not recommended.

Below is the list of medicines, which have the same composition, strength and form as Pretyline 75Mg/10Mg Tablet , and hence can be used as its substitute.

• Nuromark Pnt 75Mg/10Mg Tablet

  Unimarck Healthcare Ltd

• Pregalift Nt 75 Mg/10 Mg Tablet

  Linux Laboratories

• Pregamax Nt 75Mg/10Mg Tablet

  Winmark Pharmaceuticals Pvt Ltd

• Preganza Nt Tablet

  Emcure Pharmaceuticals Ltd

• Megabid Nt 75Mg/10Mg Tablet

  Ordain Health Care Global Pvt Ltd

• Gabacure Nt 75Mg/10Mg Tablet

  HBC Lifesciences Pvt Ltd

• Neurotin-Nt Tablet

  Medsol India Overseas Pvt Ltd

• NERVILAX NT 75MG/10MG TABLET

  Saffron Therapeutics Pvt Ltd

• Zylin Nt 75 Mg/10 Mg Tablet

  Zydus Cadila

• Prenura Nt Tablet

  Pulse Pharmaceuticals

• Missed Dose instructions

  Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose can be skipped.

• Are there any overdose instructions?

  Contact your doctor immediately if an overdose is suspected. Symptoms of overdose may include agitation, mental confusion, excessive drowsiness.

This medication is a combination of Pregabalin and Nortriptyline, thus work through dual mechanism of action. Primarily, it behaves as a GABA analogue and binds to the voltage-gated calcium channels in the central nervous system. This causes a reduced release of neurotransmitters like serotonin, dopamine, substance P thus slowing down nerve signals. Secondarily, it blocks the serotonin reuptake at the neuronal membrane. Also, it inhibits the reuptake of norepinephrine and raises its concentration in the synaptic cleft.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Ethanol

  Avoid or limit the use of alcohol while taking this medicine. One should refrain from operating heavy machinery or performing works that require a high level of mental alertness.

• Interaction with Medicine

  Lorazepam

  Report the use of Lorazepam or any other medicine that you take for sleep disorders or anxiety problems. The risk of adverse effects like dizziness, drowsiness, confusion, lack of focus, etc., is very high while taking these medicines together. Special precaution is advised if these medicines are taken by an elderly person.

  Pioglitazone

  Report the use of Pregabalin to the doctor before receiving Pioglitazone or any other medicine used for controlling high blood sugar levels. These medicines could increase the risk of weight gain, fluid retention, and heart failure when taken together. You may need a dose adjustment and frequent monitoring to safely use these medicines together.

  Ramipril

  Report the use of Ramipril or any other medicine belonging to the class of ACE inhibitors used for lowering blood pressure. The risk of fluid retention and associated adverse effects on the heart are significantly increased when these medicines are used together.

  Oxycodone

  Report the use of any opiate pain medicines to the doctor before receiving Pregabalin. Using these medicines together can cause severe dizziness, confusion, lack of coordination especially in the elderly and people with a history of emotional disturbances, suicidal thoughts, alcohol abuse, or drug abuse. Any such effect while using them together should be reported to the doctor.

• Interaction with Disease

  Angioedema

  This medicine should be administered with caution in patients who have a history of or are at risk of developing swellings of the inner layers of the skin. These swellings can cause airway blockage and prove life-threatening.

• Interaction with Food

  Food

  Information not available.

• Ques : What is Pretyline 75Mg/10Mg Tablet?

  Ans : This medication is a combination of Pregabalin and Nortriptyline and is considered to be the first-line of treatment for neurotic pain, shingles, seizures and fibromyalgia.

• Ques : How long do I need to use Pretyline 75Mg/10Mg Tablet before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use Pretyline 75Mg/10Mg Tablet?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Pretyline 75Mg/10Mg Tablet empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : What are the instructions for the storage and disposal of Pretyline 75Mg/10Mg Tablet?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Nortriptyline- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 23 January 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/pregabalin

• Pregabalin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 23 January 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/nortriptyline

• Nortriptyline 10 mg Film-coated Tablets [Internet]. medicines.org.uk 2019 [Cited 23 January 2020]. Available from:

  https://www.medicines.org.uk/emc/medicine/32962