Probenecid

Probenecid helps in the prevention of gouty arthritis; hyperuricemia; prolongation of beta-lactam effect (ie, serum levels). It is advised to take the dose as prescribed by the doctor.

You must immediately stop using Probenecid and inform your doctor if you notice a rash, dizziness, itching, sore gums, painful urination, etc. Women who are pregnant or breastfeeding must take medical help before consuming this drug.

Use Probenecid with caution in patients with peptic ulcer. Use extreme caution in the use of Probenecid with penicillin in patients with renal insufficiency. Probenecid may not be effective in patients with a creatinine clearance <30 to 50 mL/minute; may cause exacerbation of acute gouty attack.

Symptoms of overdose of Probenecid include nausea, vomiting, tonic-clonic seizures, coma. Use activated charcoal is especially effective at binding Probenecid, for GI decontamination.

Take as directed; do not discontinue without consulting prescriber. May take 6-12 months to reduce gouty attacks (attacks may increase in frequency and severity for the first few months of therapy).

Take with food or antacids or alkaline ash foods (milk, nuts, beets, spinach, turnip greens). Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). Avoid aspirin, or aspirin-containing substances. Diabetics should use serum glucose monitoring.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

• Gouty Arthritis

• Increased Uric Acid Level In Blood

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

• Hypersensitivity

• Peptic Ulcer

• Renal Impairment

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

• Flushing

• Rash

• Itching

• Dizziness

• Painful Urination

• Headache

• Nausea Or Vomiting

• Anorexia

• Nausea

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

• Are there any pregnancy warnings?

  Pregnant women are advised to consult a doctor before consuming this drug.

• Are there any breast-feeding warnings?

  Lactating mothers are advised to take medical help before consuming this medication.

• Is it habit forming?

  No, the medicine is not habit-forming or addictive.

• Does this affect kidney function?

  Caution must be taken in patient with kidney disease. Adjustment of the dose is needed. Kindly consult your doctor before taking this medicine.Avoid use of Probenecid in patients with renal impairment (Clcr <50 mL/minute).

• Does this affect liver function?

  Relevant information is not available. Please consult to know if any dose adjustment is needed in patients with liver impairment.

• How long is the duration of effect?

  The drug remain active for about 6-12 hours and is dose dependent.

• What is the onset of action?

  Effect on penicillin levels reached in about 2 hours

• Is it safe to drive while on this medicine?

  You are advised to start driving after taking the help of the medical practitioner.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

• Are there any overdose instructions?

  In case of an overdose, you may experience side effects like restlessness, anxiety, confusion or dizziness. In such cases, make sure that you consult a doctor with immediate effect.

• Are there any missed dose instructions?

  It is advisable that you do not miss a dosage since there is just one dose per day. Consume the missed dosage as soon as you remember.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

Below is the list of medicines, which contains Probenecid as ingredient

• Alcephin La 250 Mg/250 Mg Tablet

  Alembic Pharmaceuticals Ltd

• Unifex 250 Mg/250 Mg Tablet

  BestoChem Formulations India Ltd

• Ceff La 500Mg/500Mg Tablet

  Lupin Ltd

• Unifex 500 Mg/500 Mg Capsule

  BestoChem Formulations India Ltd

• Unifex Forte 500 Mg/250 Mg Tablet

  BestoChem Formulations India Ltd

• Moxylong Ss 250 Mg/250 Mg Tablet

  Dr Reddy s Laboratories Ltd

• Moxylong Ds 500 Mg/500 Mg Tablet

  Dr Reddy s Laboratories Ltd

• Ampilong 250 Mg/250 Mg Tablet

  Dr Reddy s Laboratories Ltd

• Apc Tablet

  Algen Healthcare Pvt Ltd

• Unifex Forte 500 Mg/250 Mg Capsule

  BestoChem Formulations India Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

Competitively inhibits the reabsorption of uric acid at the proximal convoluted tubule, thereby promoting its excretion and reducing serum uric acid levels; increases plasma levels of weak organic acids (penicillins, cephalosporins, or other beta-lactam antibiotics) by competitively inhibiting their renal tubular secretion.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Derma before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Using alcohol while taking this drug is not recommended. Any activity requiring a high level of mental alertness should be avoided in such cases.

• Interaction with Lab Test

  False-positive glucosuria with Clinitest®, a falsely high determination of theophylline has occurred and the renal excretion of phenolsulfonphthalein 17-ketosteroids and bromsulfophthalein (BSP) may be inhibited.

• Interaction with Medicine

  Decreased effect:

  • Salicylates (high dose) may decrease uricosuria.
  • Nitrofurantoin may decrease efficacy.

  Increased toxicity:

  • Increases methotrexate toxic potential; combination with diflunisal has resulted in 40% decrease in its clearance and as much as a 65% increase in plasma concentrations due to inhibition of diflunisal metabolism.
  • Probenecid decreases the clearance of beta-lactams such as penicillins and cephalosporins; increases levels/toxicity of acyclovir, thiopental, clofibrate, dyphylline, pantothenic acid, benzodiazepines, rifampin, sulfonamide, dapsone, sulfonylureas, and zidovudine.
  • Avoid concomitant use with ketorolac (and other NSAIDs) since its half-life is increased twofold and levels and toxicity are significantly increased.
  • Allopurinol readministration may be beneficial by increasing the uric acid lowering effect.
  • Pharmacologic effects of penicillamine may be attenuated.

• Interaction with Food

  Drug may cause GI upset; take with food if GI upset. Drink plenty of fluids.

• Ques : What are the uses of Probenecid?

  Ans : Probenecid is used to treat gout arthritis and gout. Probenecid helps in reducing the amount of uric acid in the body by passing it through urine.

• Ques : Is it safe to use Probenecid in patients with a history/active uric acid kidney stones?

  Ans : It is advised to not use Probenecid in a patient with a history/active case of uric acid kidney stone as it may worsen its condition.

• Ques : What is the route of elimination of Probenecid?

  Ans : Probenecid is excreted in urine as an unchanged drug and monoacyl glucuronide, the alkalinity of the drug increases the elimination of Probenecid.

• Ques : What is the half-life of Probenecid?

  Ans : The half-life of Probenecid is between 6 to 12 hours.

• Ques : Should Probenecid be taken with a meal or without a meal?

  Ans : Probenecid is more effective when taken with a meal, additionally, it reduces irritation.

• Ques : Where is Probenecid approved?

  Ans : Probenecid is approved in India, Japan, and the USA.

• Ques : What are the storage instructions of Probenecid?

  Ans : Probenecid should be approved at room temperature in dark away from light and moisture in its original packaging.