Tigecycline

Prescription vs OTC : Prescription by Doctor required

About Tigecycline

Tigecycline is an antibiotic which can be injected into the body. The drug cures a number of bacterial infections, by effectively binding over bacterial ribosomes that yield the protein in the cells. This binding action stops the bacterial ribosomes from producing such proteins that help in their multiplication. It should be noted that this drug merely prevents the multiplication of the bacteria, it does not destroy the bacteria on the whole.

When considering the most common side effects of Tigecycline, you can experience nausea accompanied with vomiting, as well as diarrhea. Various other side effects also include swelling and irritation, irregular heart rate, development of infections and pain at the site of the injection. Just like other antibiotics, Tigecycline can also lead to side effects such as higher sensitivity to light and discolored teeth.

The medicine is administered through an IV for about half an hour to one hour. The first dose may be as high as 100 mg, and the following doses may be about 50 mg given after a 12 hour interval. In case of severe skin infections or intra-abdominal infections, the time period of the treatment is about 5 to 14 days. In case of bacterial infections like pneumonia, which are community acquired, the treatment period may last for about a week or a fortnight.

Women who are pregnant or trying to conceive should discuss the benefits and risks of the drug with their health care providers before taking it. This is because Tigecycline is known to be harmful for the fetus. Even lactating mothers should be careful when taking Tigecycline.

Inform your doctor about your current medical conditions and allergies before your start the medical treatment. Also give him a list of the drugs you are already taking.

You can store the drug at room temperature in a clean as well as dry place.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

What are the uses of Tigecycline

Intra-Abdominal Infections
Tigecycline is used in the treatment of Intra-abdominal infections like Peritonitis, Appendicitis, Intra-abdominal Abscess caused by E.coli, Streptococci, and Enterococci.
Skin And Structure Infection
Tigecycline is used in the treatment of Skin and Structure infection like cellulitis, wound infection and cutaneous abscess caused by Streptococcus pyogenes and Staphylococcus aureus.
Pneumonia
Tigecycline is used in the treatment of community acquired pneumonia which is a most common type of lung infection caused by Streptococcus pneumoniae and Haemophilus influenzae.

What are the contraindications of Tigecycline ?

Allergy
Not recommended in the patients with the history of allergy to tetracyclines.

What are the side effects of Tigecycline ?

Fever With Chills
Dizziness
Headache
Diarrhoea
Irregular Heart Beat
Abdominal Pain
Yellow Colored Eyes Or Skin
Mouth Ulcers
Swelling And Redness At The Injection Site
Indigestion
Trouble Sleeping

Key highlights of Tigecycline

How long is the duration of effect?
The effect of this medicine lasts for an average duration of 2 to 3 days.
What is the onset of action?
The peak effect of this medicine can be observed immediately after an intravenous dose
Are there any pregnancy warnings?
This medicine is not recommended for pregnant women.
Is it habit forming?
No habit forming tendency have been reported.
Are there any breast-feeding warnings?
This medicine is not recommended in breastfeeding women.

What are the dosage instructions?

Missed Dose instructions
The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.
Are there any overdose instructions?
Seek emergency medical treatment or contact the doctor if any symptoms of overdose appear.

Where is the Tigecycline approved?

India
United States
Japan

Medicines containing Tigecycline

Below is the list of medicines, which contains Tigecycline as ingredient

Tigefic Plus 50 MG Injection
Gufic Bioscience Ltd
Tgkem Kit 50/50 MG Injection
Alkem Laboratories Ltd
Zutig 50 MG Injection
Zuventus Healthcare Ltd
Tygaray 50 MG Injection
Mylan
Tygacil 50 MG Injection
Pfizer Ltd
Tiziren 50 MG Injection
La Renon
Tisam 50 MG Injection
Samarth Life Sciences Pvt Ltd
Tigimax 50 MG Injection
Abbott India Ltd
Tigilyn 50 MG Injection
Hetero Healthcare Ltd
Tigi 50 MG Injection
Natco Pharma Ltd

How does this medication work?

Tigecycline belongs to the class tetracyclines. It works by stopping the growth of bacteria by inhibiting the protein synthesis by acting on 30S ribosomal subunits of susceptible bacteria.

What are the interactions of Tigecycline ?

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

Interaction with Alcohol
Alcohol
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Lab Test
Lab
Information not available.
Interaction with Medicine
Warfarin
Tigecycline may increase the effect of warfarin and may increase the risk of bleeding. Close monitoring of blood platelets is necessary. Any symptoms of unusual bleeding should be reported to the doctor. Dose adjustments or an alternate medicine should be considered based on the clinical condition.
Ethinyl Estradiol
The desired effect of contraceptive pills will not be achieved if these medicines are taken together. Appropriate dose adjustments or an alternate medicine should be considered based on the clinical condition.
Cholera Vaccine
If you have taken Tigecycline, then it is advisable to wait for 14 days before taking Cholera vaccine. Usage of other antibiotics and vaccines should be reported to the doctor.
Interaction with Disease
Colitis
Avoid if you experience severe diarrhea, abdominal pain, and blood in stools after taking Tigecycline. Inform the doctor if you are suffering from any gastrointestinal diseases. Drink adequate amount of water to prevent dehydration.
Interaction with Food
Food
Information not available.

References

Tigecycline-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 7 June 2022].Available from:
https://druginfo.nlm.nih.gov/drugportal/name/tigecycline
Tigecycline-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 7 June 2022].Available from:
https://go.drugbank.com/drugs/DB00560
TIGECYCLINE injection,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 7 June 2022].Available from:
https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=TIGECYCLINE

Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.