Xylistin 4.5 MIU Injection

Xylistin 4.5 MIU Injection is used for the treatment of diarrhea in infants and children caused by susceptible organisms, especially E. coli and Shigella, however, other agents are preferred and also for the treatment of superficial infections of external ear canal and of mastoidectomy and fenestration cavities.

Xylistin 4.5 MIU Injection is an antibiotic which treats bacterial infections by stopping the growth of bacteria. It is a very effective medicine to treat infections of the stomach and the intestine caused by sensitive gram-negative bacteria. It is also used for performing bowel sterilisation before a surgery.

During your treatment with this medicine, you may experience a few side effects like stomach upset and itching. Serious side effects may include numbness of the arms and legs, confusion, difficulty walking, psychosis, unsteadiness, unexplained fever, seizures, troubled breathing, muscle weakness, dizziness, slurred speech and signs of kidney problems.

You should not take this medicine if you have previously experienced allergies towards any of the ingredients in it or if you suffer from myasthenia gravis (a rare condition where muscle tire very fast), brain toxicity, impaired kidney function or colitis.

This medicine should not be used during a pregnancy unless absolutely necessary. Women who are breastfeeding should use it with caution. Medicines like tacrolimus, vancomycin, ethanol estradiol, streptomycin or live cholera vaccine may interfere with the action of Xylistin 4.5 MIU Injection so make sure your doctor knows if you are taking any other medicines.

Xylistin 4.5 MIU Injection is administered into the body by injecting it into a vein or a muscle as directed by your doctor. For severe gram-ve bacterial infections the usual dosage is 2.5-5 mg/kg/day in 2-4 divided doses. Maximum dose prescribed is 5 mg/kg/day.

Your prescription depends on your medical condition and response to treatment. It is recommended to keep taking this medicine for the full prescribed duration. Contact your doctor if you see no improvement in your condition.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

• Bowel Sterilization

• Gastrointestinal Infections

• Diarrhoea

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

• Allergy

• Myasthenia Gravis

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

• Nephrotoxicity

• Nausea

• Vomiting

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

• How long is the duration of effect?

  The time duration for which this medicine remains effective in the body is not clinically established.

• What is the onset of action?

  The time taken for this medicine to show its effect is subject to variations and is not clinically established.

• Are there any pregnancy warnings?

  This medicine should not be used during a pregnancy unless absolutely necessary. Consult your doctor and discuss the potential benefits and risks associated with use.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  This medicine should be used with caution by women who are breastfeeding. Consult your doctor and discuss the potential benefits and risks associated with use.

• Is It safe with alcohol?

  Consumption of alcohol while taking this medicine usually does not cause any side effect.

• Is it safe to drive while on this medicine?

  This medicine usually does not affect the patients ability to drive.

• Does this affect kidney function?

  Caution must be taken while using this medicine in patients with kidney disease. Adjustment of dose might be needed. Kindly consult your doctor before taking it.

• Does this affect liver function?

  Limited information is available regarding its use in patients with liver disease. Kindly consult your doctor before taking it.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

Below is the list of medicines, which have the same composition, strength and form as Xylistin 4.5 MIU Injection , and hence can be used as its substitute.

• Acostin 4.5 MIU Injection

  Ranbaxy Laboratories Ltd

• Coly-Monas 4.5 MIU Injection

  Glenmark Pharmaceuticals Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

• Missed Dose instructions

  Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped.

• Are there any overdose instructions?

  Contact your doctor if an overdose is suspected. Symptoms may include mental confusion, difficulty in walking, dizziness, skin irritation etc.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

This medicine acts as a cationic detergent and disrupts the bacterial cell membrane. This results in oozing out of the cell constituent and lysis of the organism.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Uro before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Lab Test

  Information not available.

• Interaction with Medicine

  Tacrolimus

  Report the use of either of the medicine to the doctor. You may need a dose adjustment and frequent clinical monitoring to safely use these medicines together. Report incidences of loss of appetite, sudden weight gain, and fluid retention to the doctor immediately.

  Vancomycin

  Report the use of either of the medicine to the doctor. You may need a dose adjustment and frequent clinical monitoring to safely use these medicines together. Report incidences of loss of appetite, sudden weight gain, and fluid retention to the doctor immediately.

  Ethinyl Estradiol

  Use of this medicine may make oral contraceptives less effective. This may result in unintended pregnancies. Other methods of contraceptions should be discussed with the doctor before treatment with colistin is initiated.

  Live cholera vaccine

  Report the use of this medicine before taking a live cholera vaccine. Any live vaccine should be taken 14 days after stopping the use of colistin.

  Streptomycin

  Report the use of either of the medicine to the doctor. You may need a dose adjustment and frequent clinical monitoring to safely use these medicines together. Report incidences of hearing or vision loss to the doctor immediately.

• Interaction with Disease

  Brain Toxicity

  The injectable form of this medicine should not be used in patients with brain damage, memory problems, anxiety, depression and other mental disorders. Your doctor will determine the best course of treatment after assessing the condition.

  Impaired Kidney Function

  This medicine should be used with caution in patients suffering from a kidney disease. Symptoms of the disease may worsen after the use of colistin. You may need a dose adjustment and more frequent clinical monitoring while using this medicine.

  Colitis

  Use of this medicine may cause severe irritation of the stomach and the intestine. Report any instance of colitis in the past or the present to the doctor. Appropriate diagnostic tests and clinical monitoring are advised before starting the treatment course with this medicine.

• Interaction with Food

  Information not available.

• Ques : What is the half-life of Xylistin 4.5 MIU Injection?

  Ans : The half-life of Xylistin 4.5 MIU Injection is about 5 hours.

• Ques : Should Xylistin 4.5 MIU Injection be taken with a meal or without a meal?

  Ans : Xylistin 4.5 MIU Injection can be taken with a meal or without a meal as its effectiveness does not depend on food.

• Ques : Does Xylistin 4.5 MIU Injection cause diarrhea?

  Ans : Xylistin 4.5 MIU Injection should be used with caution as it can induce diarrhea during or after the treatment.

• Ques : Does Xylistin 4.5 MIU Injection lead to drug resistance?

  Ans : Xylistin 4.5 MIU Injection should be used with caution and completed the duration of the prescription even after the disappearance of the side-effects and symptoms. Not doing so may cause drug resistance and further infection.

• Ques : Is Xylistin 4.5 MIU Injection safe to use for people with respiratory paralysis?

  Ans : Xylistin 4.5 MIU Injection should be used with caution in people with respiratory paralysis as it can cause respiratory failure.

• Colistin-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 3 June 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/colistin

• Colistin-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 3 June 2022].Available from:

  https://go.drugbank.com/drugs/DB00803

• COLISTIN injection,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 3 June 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=COLISTIN