Amrinone

Amrinone is used in the treatment of congestive heart failure. It is also known as inamrinone and is a type 3 pyridine phosphodiesterase inhibitor (PDE3). This medicine is a positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties and has the ability to stimulate calcium ion influx into the cardiac cell.

Being a PDE3 drug, it acts in a similar way like that of a beta-agonist. It leads to an increase in cAMP and cGMP causing an increased calcium influx, resulting in an increased inotropic effect.

In the human body, Inamrinone and several metabolites (N-glycolyl, N-acetate, O-glucuronide, and N-glucuronide) are primarily excreted through the urine. Chemical interaction with precipitation occurs with amrinone and dextrose or furosemide. Thus drug mixing should be avoided.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Heart Failure

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Hypersensitivity

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Arterial Hypotension (Low Blood Pressure)

• Headache

• Atrial Arrhythmias (Altered Heart Rate)

• Dizziness

• Diarrhoea

• Abnormal Feces

• Palpitations

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Is It safe with alcohol?

  There is no data available. Please consult a doctor before consuming the drug.

• Are there any pregnancy warnings?

  There is no data available. Please consult a doctor before consuming the drug.

• Are there any breast-feeding warnings?

  This medication is probably safe to use during lactation.

• Is it safe to drive while on this medicine?

  There is no data available. Please consult a doctor before consuming the drug.

• Does this affect kidney function?

  There is no data available. Please consult a doctor before consuming the drug.

• Does this affect liver function?

  There is no data available. Please consult a doctor before consuming the drug.

• What is the onset of action?

  The action of this medicine is initiated within 2 - 5 minutes.

• How long is the duration of effect?

  The drug will remain active for about 3 - 6 hrs, depending on the clinical condition of the patient.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Are there any missed dose instructions?

  If you miss a dose of this medication, skip it and continue with your normal schedule. Do not double the dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

Below is the list of medicines, which contains Amrinone as ingredient

• CARDIOTONE 100MG INJECTION 20ML

  Vhb Life Sciences Inc

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

This medication is cardiotonic with positive inotropic, phosphodiester inhibitory, and vasodilatory abilities. Phosphodiesterase inhibition causes an increase in cAMP and cGMP levels which causes increased calcium influx. These result in increased inotropic effect and can treat congestive heart failure.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Medicine

  Furosemide: A precipitate forms on admixture with amrinone.

  Diuretics may cause significant hypovolemia and decrease filling pressure.

  Digitalis: Inotropic effects are additive.

• Ques : What is Amrinone?

  Ans : This medication is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure.

• Ques : How long do I need to use Amrinone before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use Amrinone?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Amrinone empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : What are the instructions for the storage and disposal of Amrinone?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Inamrinone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 16 December 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/rn/60719-84-8

• Amrinone- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 16 December 2019]. Available from:

  https://www.drugbank.ca/drugs/DB01427

• Inamrinone [Internet]. Mychart.geisinger.org. 2018 [Cited 16 December 2019]. Available from:

  https://mychart.geisinger.org/Staywel/html/Drug%20Sheets/26,36.html