Pipzo 4.5Gm Injection

Pipzo 4.5Gm Injection is prescribed for the treatment of infections of lower respiratory tract, urinary tract, skin and skin structures, gynecologic, bone and joint infections, and septicemia caused by susceptible organisms.

Tazobactam expands activity of piperacillin to include beta-lactamase producing strains of S. aureus, H. influenzae, Bacteroides, and other gram-negative bacteria.

Symptoms of penicillin overdose include neuromuscular hypersensitivity (agitation, hallucinations, asterixis, encephalopathy, confusion, and seizures) and electrolyte imbalance with potassium or sodium salts, especially in renal dysfunction.

Hemodialysis may be helpful to aid in the removal of the drug from the blood, otherwise most treatment is supportive or symptom directed.

It works by Inhibiting bacterial cell wall synthesis by binding to one or more of the penicillin binding proteins (PBPs); which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis.

Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Tazobactam inhibits many beta-lactamases, including staphylococcal penicillinase and Richmond and Sykes types II, III, IV, and V, including extended spectrum enzymes; it has only limited activity against class I beta-lactamases other than class Ic types.

This medication will be administered I.V. or I.M. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). Small frequent meals, frequent mouth care, sucking lozenges, or chewing gum may reduce nausea or dry mouth.

Important to maintain good oral and vaginal hygiene to reduce incidence of opportunistic infection. Diabetics should use serum glucose testing while receiving this medication. If diabetic, drug may cause false tests with Clinitest® urine glucose monitoring; use of glucose oxidase methods (Clinistix®) or serum glucose monitoring is preferable.

This drug may interfere with oral contraceptives; an alternate form of birth control should be used. Report persistent diarrhea, fever, chills, unhealed sores, bloody urine or stool, muscle pain, mouth sores, or difficulty breathing, or skin rash.

• Bacterial Infections

• Skin And Structure Infection

• Lower Respiratory Tract Infection

• Urinary Tract Infection

• Gynecological Infections

• Allergy

  This medication is contraindicated if you are allergic to it or any of its components.

• Diarrhoea

• Hypertension

• Insomnia

• Headache

• Agitation

• Fever

• Dizziness

• Rash

• Pruritus

• Nausea

• Dyspepsia

• Rhinitis

• Is It safe with alcohol?

  Interaction with alcohol is unknown. Please consult your doctor.

• Are there any pregnancy warnings?

  This injection should be avoided by pregnant women unless suggested by the doctor.

• Are there any breast-feeding warnings?

  Use by the breast-feeding mother may result in diarrhea, candidiasis, or allergic response in the infant. Consult prescriber if breast-feeding.

• Is it safe to drive while on this medicine?

  This medicine does not affect the consciousness of the patient thus one can drive while taking this.

• Does this affect kidney function?

  Dosing interval in renal impairment:

  • Clcr 20-40 mL/minute: Administer 2/0.25 g every 6 hours.
  • Clcr <20 mL/minute: Administer 2/0.25 g every 8 hours.
  • Hemodialysis: Administer 2/0.25 g every 8 hours with an additional dose of 0.75 g after each dialysis.
  • Continuous arteriovenous or venovenous hemodiafiltration (CAVH) effects: Dose as for Clcr 10-50 mL/minute.
  Kindly consult your doctor before taking this medication.

• Does this affect liver function?

  No relevant information available.

Below is the list of medicines, which have the same composition, strength and form as Pipzo 4.5Gm Injection , and hence can be used as its substitute.

• Tazcan 4000 mg/500 mg Injection

  Cipla Ltd

• Tazacillin 4000 Mg/500 Mg Injection

  Nitin Lifesciences Ltd

• Maxotaz 4000 Mg/500 Mg Injection

  Macleods Pharmaceuticals Pvt Ltd

• Durataz 4000 Mg/500 Mg Injection

  Aristo Pharmaceuticals Pvt Ltd

• Tazowin Injection

  Themis Medicare Ltd

• Piptaz 4000 Mg/500 Mg Injection

  Vhb Life Sciences Inc

• Tazar 4.5 G Injection

  Lupin Ltd

• Tripep-T Injection

  Triglobal Bioscience Pvt Ltd

• Tazact 4.5 Gm Injection

  Cipla Ltd

• Tazomac 4000 mg/500 mg Injection

  Macleods Pharmaceuticals Pvt Ltd

• Are there any missed dose instructions?

  Missed Dose: Missed dose should be taken as soon as possible. It is recommended to skip your missed dose, if it is the time for your next scheduled dose.

• Are there any overdose instructions?

  Consult your doctor in case of overdose.

This injection is an antibacterial drug that is injected intravenously or intramuscularly to prevent bacterial infection. It kills the bacteria by preventing them from forming their cell walls by binding with certain penicillin binding proteins present in the bacterial cells. his medication also works as a beta-lactamase inhibitor by binding to beta-lactamase enzyme produced by bacterial cells, which in turn inhibits its enzymatic action and prevents beta-lactam antibiotics from being metabolised by the enzyme.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

test

• Interaction with Lab Test

  This medicine might result in Positive Coombs' [direct] test 3.8%, ALT, AST, bilirubin, and LDH.

• Interaction with Medicine

  • Decreased effect: Tetracyclines may decrease penicillin effectiveness; aminoglycosides physical inactivation of aminoglycosides in the presence of high concentrations of piperacillin and potential toxicity in patients with mild to moderate renal dysfunction; decreased efficacy of oral contraceptives is possible.
  • Increased effect:
  • Probenecid may increase penicillin levels.
  • Neuromuscular blockers may increase duration of blockade.
  • Aminoglycosides synergistic efficacy.
  • Heparin with high-dose parenteral penicillins may result in increased risk of bleeding.

• Interaction with Disease

  Due to sodium load and to the adverse effects of high serum concentrations of penicillins, dosage modification is required in patients with impaired or underdeveloped renal function; use with caution in patients with seizures or in patients with history of beta-lactam allergy; safety and efficacy have not been established in children <12 years of age.

• Ques : What is Pipzo 4.5Gm Injection?

  Ans : This medication is classified as an antibacterial agent, is used for treating several serious bacterial infections. It contains Piperacillin and Tazobactam as active ingredients. Pipzo Injection works by blocking the bacteria's cell wall growth which kills the bacteria; preventing the destruction of antibiotics from chemicals released from bacteria.

• Ques : What are the uses of Pipzo 4.5Gm Injection?

  Ans : This injection is used for the treatment and prevention from conditions and symptoms of diseases like pneumonia, kidney infections, bacterial infections of skin, bones and joint infections.

• Ques : What are the Side Effects of Pipzo 4.5Gm Injection?

  Ans : Side effects include the inability to sleep, cephalalgia, diarrhea, deficiency of potassium in the blood. If any of these symptoms occur often or on daily basis, a doctor should be urgently consulted.

• Ques : What are the instructions for storage and disposal Pipzo 4.5Gm Injection?

  Ans : Store at controlled room temperature; after reconstitution, solution is stable in NS or D5W for 24 hours at room temperature and 7 days when refrigerated; use single dose vials immediately after reconstitution (discard unused portions after 24 hours at room temperature and 48 hours if refrigerated).

• Ques : How long do I need to use Pipzo 4.5Gm Injection before I see improvement of my conditions?

  Ans : This injection takes 1 or 2 days before you see an improvement in your health conditions.

• Ques : What are the contraindications to Pipzo 4.5Gm Injection?

  Ans : This medication should not be used if you have the following conditions such as Allergic reactions and Hypersensitivity.

• Ques : Is Pipzo 4.5Gm Injection safe to use when pregnant?

  Ans : This medication is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

• Ques : Will Pipzo 4.5Gm Injection be more effective if taken in more than the recommended dose?

  Ans : No, taking higher than the recommended dose of this injection can lead to increased chances of side effects such as Emesis, Inability to sleep, Cephalalgia, Diarrhea, Deficiency of potassium in blood, Inflammation of mouth and lips, Severe allergic reactions, Itching of skin, Indigestion, Feeling of sickness, Abnormal blood counts, Vomiting, Increased liver enzymes, Low blood pressure, Skin rash, Increased blood creatinine, Constipation, etc.

• Tazobactum- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 15 May 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/rn/89786-04-9

• Tazobactum- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 15 May 2019]. Available from:

  https://www.drugbank.ca/drugs/DB01606

• Piperacillin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 16 May 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/rn/61477-96-1

• Piperacillin- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 15 May 2019]. Available from:

  https://www.drugbank.ca/drugs/DB00319