The Herpes simplex virus (HSV) is an enveloped, DNA containing virus morphologically similar to the other members of the herpesviridae family. There are two naturally occurring variants of HSV(HSV 1 and HSV 2) both types of virus cause infections in humans which range in severity from cold sores to encephalitis. The diagnosis of HSV infections is routinely made based on clinical findings and supported by laboratory testing which includes Direct fluorescent antibody (DFA), Immunoblot (IgG), Culture and Typing (ELVIS®), Culture Without Typing, Enzyme-linked Immunosorbent Assay (ELISA) IgM and Type-Specific IgG, DNA Polymerase Chain Reaction (PCR) and Chemiluminescent immunoassay (CLIA).