Anti-smooth-muscle antibody is like ANA (anti-nuclear antibodies) that are produced in a human body when the immune system fails to identify between self and non-self adequately. This is when the autoantibodies trespass the body's cells. It causes, autoimmune hepatitis and other forms of liver diseases like primary biliary cholangitis (PBC), Anti-smooth-muscle antibody kind of antibodies is formed against smooth muscle. The tests on these are conducted to identify the presence of autoantibodies in the blood of a human being. These antibodies can be directed against actin, troponin, and tropomyosin. Patients suffering from hepatitis are often asked to go for the test. Doctors recommend undergoing this test if the patient is showing symptoms of the autoimmune disorder. The test is also conducted on patients complaining of fatigue and jaundice that shows abnormal liver tests reports.