For many pregnant women, the second trimester is the easiest three months. During these months, the initial morning sickness and fatigue you experienced start leaving and you start feeling energetic again. It is during this period that your baby grows quickly. The second-trimester screen, also known as the quad screen, is a blood test, done between 15 weeks and 20 weeks of pregnancy. The screening helps in finding out and ascertaining the likeness and chances of your baby getting genetic diseases or birth defects. The quad screening, or second-trimester screening, poses no threat to the mother or baby.