Sjogren's (SHOW-grins) syndrome is a disorder of the immune system having the symptoms of dry eyes and a dry mouth. Sjogren syndrome can be established by getting blood tests done SS-A-Ro. Anti-Ro antibodies, also known as anti-SSA antibodies. The reference range of anti-Ro antibodies is negative. A positive anti-Ro result is revealed and known by a speckled appearance under immune fluorescence with ultraviolet light. Anti-Ro levels may be elevated in the following conditions: Sjögren syndrome: 60%-70% of cases Systemic lupus erythematosus (SLE): 25% of cases Both anti-Ro/SSA and anti-La/SSB are usually absent in secondary Sjögren syndrome. When anti-Ro/SSA levels are elevated in SLE, it is often in antinuclear antibody (ANA)–negative lupus. Anti-Ro/SSA plus anti-La/SSB is associated with the following factors: Age older than 50 years HLA-DR3 Lower likelihood of anti-DNA antibodies