Amenorrhea is the absence of menstruation; one or more missed menstrual periods. Women who have missed at least three menstrual periods in a row have amenorrhea, also girls who haven't begun menstruation by age 15. The most common cause of amenorrhea is pregnancy. Other causes of amenorrhea include problems with the reproductive organs or with the glands that help regulate hormone levels. Treatment of the underlying condition often resolves amenorrhea. The main sign of amenorrhea is the absence of menstrual periods. Depending on the cause of amenorrhea, you might experience other signs or symptoms along with the absence of periods, such as: Milky nipple discharge, Hair loss, Vision changes, Excess facial hair, Pelvic pain.