Anti-CCP is an autoantibody produced by the patient’s immune system that attacks the body. These attacks can produce inflammatory symptoms most commonly experienced in rheumatoid arthritis. Anti-CCPs can also exist in a patient for years before they ever develop clinical rheumatoid arthritis symptoms. Anti-CCP positive testing is also used to help doctors deliver a prognosis because many anti-CCP positive patients experience severe rheumatoid arthritis symptoms. The specific cause of developing anti-CCP antibodies in patients is unknown although it is thought to be a combination of genetics and environmental factors. Some researchers also say that there is a strong connection between smoking and rheumatoid arthritis.