Anti SSB antibodies are primarily anti-nuclear antibodies which are associated with various autoimmune diseases. It mainly includes systemic lupus erythematosus (SLE), SS/SLE overlap syndrome, subacute cutaneous, primary biliary cirrhosis etc. Anti SSB antibody blood test is done to determine whether SSB antibody is present in the blood or not. It helps in evaluating patients with various signs and symptoms of a connective tissue disease. If the test is positive, then it indicates the presence of the disease. SS-A is mainly composed of protein antigens and cytoplasmic RNA species. Hence, this test is essential for people with ‘connective tissue’ disease. Depending upon the report of this test further treatment and advice is provided by the doctor or the medical practitioner. One might also be needing this test if they suffer from certain syndrome such as dry eyes. Muscle pain, arthritis, dry skin, sore tongue etc.