The beta-2 microglobulin (B2M) test may be used when known physical or suspected kidney damage occurs to distinguish between glomerular and and tubular disorders of the kidney. B2M levels will also increase with disorders that involve overactive cell turnover and when the immune system is activated, thus is not diagnostic for a specific disease. With renal failure, it provides additional information about someone's likely prognosis and the health of their kidneys. B2M is measured in the situation like - In kidney disease, both blood and urine B2M tests may be ordered along with other kidney function tests such as BUN, creatinine, and microalbumin to evaluate kidney damage or disease and to distinguish between disorders that affect the glomeruli and the renal tubules.