HC stains are very useful category of special tests. IHC or immunohistochemistry is used in diagnosis of abnormal cells such as those found in cancerous tumors. It is based on the principle that each type of antibody recognizes and attaches to antigens that fit it exactly. If the cells have specific antigen, they will attract the antibody that fits the antigen. Chemicals are added that make the cells change color only if a certain antibody is present. Synaptophysin is a glycoprotein that is an integral part of the neuroendocrine secretory granule membrane and is recognized by monoclonal antibody in a variety of neuroendocrine tumors. Using IHC, synaptophysin can be demonstrated in a range of neural and neuroendocrine tissues. As a specific maker for these tissues, it can be used to identify tumors arising from them. Synaptophysin is reliable, and hence, is the most commonly used IHC marker for neuronal differentiated tumor. It is performed to confirm neuroendocrine Tumors and also during the treatment and after the treatment of Neuroendocrine Tumors. It is also known as IHC Marker Synaptophysin Immunohistochemistry Biopsy Tissue.