Mirtazapine
About Mirtazapine
Primarily used to cure depressive disorders, Mirtazapine falls under the category of anti-depressants. Though the functioning of thisdrug hasn’t been fully worked upon, it is thought to positively impact thenerve cell’s (of the CNS) communication among each other and/or regulate thebrain’s chemical balance.
However, if you are being administered tryptophan,then Mirtazapine shouldn’t be prescribed. Also, if you havebeen/have used any MOA inhibitor in the last two weeks, then it is recommendedto not take Mirtazapine as a potentially dangerous chemicalreaction might occur.
One thing to note here is that sudden and oftenviolent mood swings might result from the usage of Mirtazapine, also suicidal tendencies, for that matter. Forthis reason, the immediate family and other caregivers should be around thepatient to report any abnormal mood swings, symptoms or behavior. Mirtazapineisn’t recommended for children and those below the age of 18 years.
Remember to not discontinue the drug prematurely, otherwise the results wouldn’t be the ones that have been guaranteed; on thecontrary, side effects could swell up. Reduce alcohol consumption or quit itabsolutely because alcohol further increases the risks and side effects of Mirtazapine. Report to your doctor if you do not experienceany improvement in your condition even after using this drug for a month.
To ensure maximum safety, let your doctor know if you suffer from kidney or liver diseases, glaucoma (narrow angle), manic depressive disorders, epilepsy orseizures, a low B.P, high cholesterol count, angina, stroke, past history ofheart disorders or heart attacks, suicidal tendencies, drug abuse, etc.
Usually administered once daily right before bed, you could swallow the tablet along with water or just chew it till it dissolves completely. If you happen to skip a dose by chance, take it as soon as you can. However, if it’s almost time for the next scheduled dose, then there’s no pointin taking the missed dose again.
Take exactly as directed (do not increase dose or frequency); may take 2-3 weeks to achieve desired results. Take once-a-day dose at bedtime. Avoid excessive alcohol, caffeine, and other prescription or OTC medications not approved by prescriber. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake).
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.
What are the uses of Mirtazapine
Depression
This medicine is used to relieve symptoms of major depression. These symptoms may include sadness, loss of interest, irritability and sleeplessness. The symptoms are very severe and may impair the normal quality of life.
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.
What are the contraindications of Mirtazapine ?
Monoamine oxidase inhibitors (MAOI)
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.
What are the side effects of Mirtazapine ?
Increased Appetite
Weight Gain
Edema (Swelling)
Abnormal Dreams
Abnormal Thoughts
Confusion
Arthralgia
Weakness
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.
Key highlights of Mirtazapine
How long is the duration of effect?
The amount of time for which this medicine remains effective in the body is not clinically established.
What is the onset of action?
The amount of time taken for this medicine to show its effect is not clinically established.
Are there any pregnancy warnings?
This medicine is not recommended for use in pregnant women unless clearly needed and the benefits outweigh the risks. Consult your doctor before using this medicine.
Is it habit forming?
No habit forming tendencies were reported.
Are there any breast-feeding warnings?
This medicine is not recommended for use in breastfeeding women. It is advised to discontinue breastfeeding if the use of the medicine is necessary. Consult your doctor and discuss the risks before starting the use of this medicine.
Is It safe with alcohol?
It is found to be unsafe to consume alcohol while taking this medicine.
Is it safe to drive while on this medicine?
This medicine affects the alertness of the patient, thus driving must be avoided while taking this medicine.
Does this affect kidney function?
Caution must be taken while using this medicine in patients with kidney disease. Adjustment of dose might be needed. Kindly consult your doctor before taking it.
Does this affect liver function?
Caution must be taken while using this medicine in patients with liver disease. Adjustment of dose might be needed. Kindly consult your doctor before taking it.
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.
What are the dosage instructions?
Missed Dose instructions
Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose can be skipped.
Are there any overdose instructions?
Contact your doctor immediately if an overdose with this medicine is suspected. Symptoms of an overdose may include confusion, difficulty in recalling past incidents, increased pulse rate, and drowsiness.
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.
Where is the Mirtazapine approved?
India
United States
Japan
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.
Medicines containing Mirtazapine
Below is the list of medicines, which contains Mirtazapine as ingredient
- Mirazep 15 MG Tablet
Micro Labs Ltd
- Mizhra 7.5 MG Tablet
Usv Ltd
- Mirpine 15 MG Tablet
Psycormedies
- Mirza 7.5 MG Tablet
Nusearch Organic
- Mitrapil 7.5 MG Tablet
Psychotropics India Ltd
- M-Zap 15 MG Tablet
Reliance Formulation Pvt Ltd
- Nutaz 15 MG Tablet
Mankind Pharmaceuticals Ltd
- Mirzest 7.5 MG Tablet
La Pharmaceuticals
- Mirtex 15 MG Tablet
Alteus Biogenics Pvt.Ltd
- Mirnite 15 MG Tablet
Intas Pharmaceuticals Ltd
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.
How does this medication work?
This medication works by increasing the activity of noradrenaline and decreasing the levels of histamine. It also affects the binding of serotonin to specific receptors. It helps in restoring the chemical balance in the brain.
Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.
What are the interactions of Mirtazapine ?
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
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Interaction with Alcohol
Ethanol
Avoid or limit the uptake of alcohol while taking this medicine. Avoid activities requiring mental alertness such as driving or operating machinery after taking this medicine.Interaction with Lab Test
Lab
Information not available.Interaction with Medicine
- CYP1A2, 2C9, 2D6, and 3A3/4 enzyme substrate.
- Possibly serious or fatal reactions can occur when given with or when given within 14 days of a monoamine oxidase inhibitor.
Interaction with Food
Food
Information not available.Interaction with Disease
- Discontinue immediately if signs and symptoms of neutropenia/agranulocytosis occur. May cause sedation, resulting in impaired performance of tasks requiring alertness (ie, operating machinery or driving).
- Sedative effects may be additive with other CNS depressants and/or ethanol. The degree of sedation is moderate-high relative to other antidepressants.
- May worsen psychosis in some patients or precipitate a shift to mania or hypomania in patients with bipolar disease.
- The risks of orthostatic hypotension or anticholinergic effects are low relative to other antidepressants.
- The incidence of sexual dysfunction with mirtazapine is generally lower than with SSRIs.
FAQs about Mirtazapine
Ques : What is Mirtazapine?
Ans : Primarily used to cure depressive disorders, Mirtazapine falls under the category of antidepressants. Though the functioning of this drug hasn’t been fully worked upon, it is thought to positively impact the nerve cell’s (of the CNS) communication among each other and/or regulate the brain's chemical balance.
Ques : What are the uses of Mirtazapine?
Ans : Mirtazapine used for the treatment of Depression.
Ques : What are the side effects of this Mirtazapine?
Ans : Possible side effects of this tablet are as follows:
- Constipation
- Increased Appetite
- Weight Gain
- Hypertension
- Edema (Swelling)
- Dizziness
Ques : How long do I need to use Mirtazapine before I see improvement in my condition?
Ans : This medication is to be taken till the time you see an improvement in your health conditions.
Ques : At what frequency do I need to use Mirtazapine?
Ans : This medication should be taken in the dosage as prescribed by the doctor.
Ques : Should I use Mirtazapine empty stomach, before food or after food?
Ans : This medication should be taken after food in a prescribed dosage.
Ques : What are the instructions for the storage and disposal of Mirtazapine?
Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.
Ques : How is this Mirtazapine administered?
Ans : This medication is administered orally.
References
Mirtazapine-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 7 June 2022].Available from:
https://druginfo.nlm.nih.gov/drugportal/name/mirtazapine
Mirtazapine-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 7 June 2022].Available from:
https://go.drugbank.com/drugs/DB00370
MIRTAZAPINE tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 7 June 2022].Available from:
https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=MIRTAZAPINE
Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.
Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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