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D Dimer Test

D Dimer Test

D-Dimer is a type of protein which is produced when a blood clot dissolves in the body. D-Dimer is normally undetectable unless the body is forming or breaking down the blood clots and the level of D-Dimer rises in the blood. To check the level of D-Dimer in the blood, D-Dimer test is conducted. D-Dimer test is used in a hospital emergency room setting to determine if the person is at intermediate or low risk for thrombosis or thrombotic embolism. A negative D- Dimer test indicates that it is highly unlikely that a thrombus is present. Also, a positive D-Dimer test cannot detect whether a blood clot is present or not and indicates that further testing is required. A blood clot can cause health problems like Stroke, Deep Vein Thrombosis, Disseminated Intravascular Coagulation or Deep Vein Thrombosis.

There are no special preparations or outrageous requirement before the D-Dimer blood test. However, there is no need to fast before the test. You can have your daily food and drink before the test. Also, you can have your vitamins, medicines or other supplements as usual. You just need to know about the do’s and don’ts related to the laboratory. You also need to inform the doctor if you are on specific medications or taking blood thinners that relate to blood clotting. The test results might get affected if you do not inform your doctor prior to the test.

As already mentioned above, the D-Dimer blood test is used to assess the risk of forming dangerous blood clots. It is performed to check and confirm the presence of thrombosis in the body. Also, it helps in indicating several risks like pulmonary embolism, where a blood clot blocks the flow of blood to the lungs, deep vein thrombosis, where large blood clots form in the legs and disseminated vascular coagulation, where an individual’s blood does not coagulate when it is supposed to do so. The test is often ordered by the doctors when they suspect blood clotting disorders or are at risk of such maladies.

The D-Dimer test is usually done by ELISA assay. The test is performed by just collecting a blood sample from the patient. The doctor uses a needle to take few milliliters of blood by injecting it into the vein on your arm. You might feel a stinging or pinch when the needle is injected but it last for just a few minutes. The blood sample collected is then analyzed to find out the presence of the protein in the blood. The evaluated reference ranges from 0-300 nanograms/milliliter of D-Dimer blood test.

LimitationsResults of this test should always be interpreted in conjunction with the patient's medical history, clinical presentation, and other findings. DVT clinical diagnosis should not be based on the result of Innovance® D-dimer alone.D-dimer levels can be elevated in many clinical circumstances, especially in hospitalized patients. D-dimer should not be used as an aid for exclusion of venous thrombosis or pulmonary embolism in pediatric patients in any circumstance and adult patients with6-8:• Therapeutic dose anticoagulant administered for >24 hours before D-dimer is measured• Thrombosis distal to the knee only• Fibrinolytic therapy within previous seven days• Upper extremity thrombosis• D-dimer levels may be falsely negative if the elapsed time between thrombosis onset and D-dimer measurement is sufficient such that D-dimer has been cleared from the circulation.The following conditions are associated with an increase in D-dimer concentrations, even in the absence of venous thrombosis:• Aortic aneurysm• Trauma or surgery within previous four weeks• Disseminated malignancies• Disseminated intravascular coagulation• Sickle cell disease• Sepsis, severe infections, pneumonia, severe skin infections• Liver cirrhosis• PregnancyAlso note6:• Patient samples may contain heterophilic antibodies (eg, human antimouse antibodies [HAMA] and rheumatoid factors) that could react in immunoassays to yield falsely elevated results. This assay has been designed to minimize interference from heterophilic antibodies. Nevertheless, complete elimination of this interference from all patient specimens cannot be guaranteed.• Patients with subsegmental/peripheral PE or distal DVT may have a normal Innovance® D-dimer result.9,10• Exclusionary claim of PE in patients with high PTP scores has not been established.
Specimen
Plasma, frozen
Volume
2 mL
Container
Blue-top (sodium citrate) tube.
Type Gender Age-Group Value
D-Dimer
Unisex
All age groups
< 250 ng/ml
Average price range of the test is between Rs.800 to Rs.2200 depending on the factors of city, quality and availablity.

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Table of Content

What is D Dimer Test?
Preparation for D Dimer Test
Uses of D Dimer Test
Procedure for D Dimer Test
Limitations of D Dimer Test
Specimen Requirements
Normal values for D Dimer Test
Price for D Dimer Test

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