Factor XI Mutation Test

Factor XI which is also known as thromboplastin antecedent It is one of the enzymes of the coagulation cascade which is in the zymogen form of factor XIa. Like other coagulation factors, it is a serine protease. The Liver produces Factor XI (FXI), synthesized as a single polypeptide chain, but circulates as a homo-dimer in its inactive form. In case there is any problem with factor XI it results in its deficiency. When the body produces less factor XI than it should, the clotting reaction will be blocked and blood clot does not form, which leads to an inherited bleeding. After the surgery, there will be continuous bleeding which is the most common feature of Factor XI. Bleeding will be there for the surgeries especially involving in inside of mouth and nose. Due to the disruptions or changes to the F11 gene the Factor XI deficiency is caused and can occur in people of either sex.

Health care provider should give information about how the blood is collected. The Doctor should also explain the patient about the little pain that would be there when extracting the blood sample. Generally, No diet or fluid restriction is recommended before the collection of fluid. The culture media which are inoculated with the aspirated fluid should be handled with extreme care as they highly contagious as they contain likely bacteria. Therefore spread of bacteria through these media is really very easy. Healthcare provider should ask whether the patient is allergic to latex.

With the help of this test, diagnosis is made through a bleeding time test, platelet function tests, and prothrombin time (PT) and activated partial thromboplastin time (aPTT) tests. The amount of factor XI in the blood can be measured with the help of this test. It is also used to differentiate and manage blood-clotting disorders. In order to detect the coagulation factor XI this test is done.

A band should be wrapped around the arm, 3-4 inches above the site where the needle is inserted. The site should be cleaned with 70% alcohol away from the zone where the needle is inserted. Wit