It’s an enzyme which stabilizes the blood clotting system. The main function of Factor XIII or fibrin is to interlink the fibrin which is basic clotting unit. It consists of two subunits Factor XIII A and Factor XIIIB. A is the active portion of this molecule while B has the accessory function. B portion acts as the carrier and inhibits protein degradation within the plasma. Normal standard range of Factor XIIIA and Factor XIII B is 60-130u/DL.
• Initial screening involves sampling of patients plasma. Plasma sample is clotted by an excess of calcium followed by incubation at an optimum temperature for 30 minutes.
• Calcium has an alternative of thrombin and saline which are commonly used for clotting purpose.
• The sample is kept in 5M urea for 24 hours. If clot dissolves then FXIII deficiency is confirmed, and further Factor XIII assay is performed.
•This test is useful for patients with inheritable fibrin deficiency.
•Many times patients who undergo cardiopulmonary bypass are also prone to Factor XIII deficiency.
•During pregnancy Factor XIII levels fall causing recurrent miscarriage, therefore fibrin testing is recommended at every level of pregnancy.
•Patients suffering from chronic bowel disorder are prescribed to have a Factor XIII assay test.
Chromogenic FXIII Assays •Chroma refers to ‘color,' therefore its clear from the nomenclature of this test is based upon color observation. •FXIIIA level is checked by transglutaminase activity. •Different intensity of color produced indicates the corresponding FXIII A concentrations. ELISA Assays for FXIIIA •ELISA stands for enzyme-linked immune sorbent assay.
•This is used for testing both FXIIIA and FXIIIB.
•FXIIIA is tested first if it turns out to be low then B part is investigated. Thromboelastogram
•Its an advanced graphical method to analyze FXIII deficiency. Functional FXIII Assays •Transglutamidase activity of FXIIIA forms the basis of this testing.
•By measuring the amount of ammonia produced during the transglutaminase activity, we can measure the level of fibrin deficiency.
•The reference range of this testing lies between 0->250%.
Type | Gender | Age-Group | Value |
---|---|---|---|
Factor XIII Assay
|
Unisex
|
All age groups
|
57 - 192%
|
Arthritis is a joint disorder featuring inflammation. A joint is an area of the body where two different bones meet. A joint in the body functions to move the body parts connected by its bones. Arthritis literally means inflammation of one or more joints.
Arthritis is frequently accompanied by joint pain. Joint pain is referred to as arthralgia. When four or more joints are involved, the arthritis is referred to as polyarthritis. When two or three joints are involved, it is referred to as oligoarthritis. When only a single joint is involved, it is referred to as monoarthritis.
Cause of arthritis
It is difficult to narrow down a single cause for it, but a combination of reasons may trigger this disease.
Symptoms of arthritis
Most common signs on the onset of this disease are stiffness, redness of the skin around a joint, pain due to inflammation, it might also affect your immune system causing a loss appetite if the disease is because of your immune system.
How can Ayurveda help?
Ayurveda can work wonders for this disease since a right combination of nourishing herbs and stable yoga postures improve your joint health for a longer time. Since the treatment is totally organic, the calcium absorption of your body is increased naturally without any side effects. Even Ayurvedic oils work well for joint pain and give you quick relief. If you have been to able to find the right treatment then Ayurveda is for you. If you wish to discuss about any specific problem, you can consult an ayurveda.
Supplements are just a way to add vital nutrients in your daily nutritional intake, but are not the only solution. First of all, it is important to note that your sex life does not depend on supplements. Various other factors can both positively and negatively affect your sex life. Exercise, weight and medications you take can have both adverse and positive effects. Try to improve your sex life by altering these aspects before you use supplements. Nevertheless, here are some supplements which may be beneficial for your sex life.
Impotence is embarrassing for a man. It not only affects his self-confidence, but also the relationship with his partner. It is a condition in which a man cannot achieve an erection for having sex. If you are experiencing symptoms of impotence, they are most likely due to physical issues. However, sometimes psychological issues can also be responsible for impotence.
Here are 5 psychological factors, which may be associated with the inability to achieve an erection indicating impotence:
Stress: To a great extent, stress affects a person’s performance in bed. Due to excessive stress and pressure arising from different responsibilities and commitments, he might not be able to focus on sex. Extreme stress due to fear may leave him uneasy, thereby making it difficult for him to have an erection.
Anxiety: After experiencing symptoms of impotency, it is likely that a man may get extremely anxious about the fact that he will not be able to perform well in bed again. This anxiety may also arise from relationship problems, sexual abuse in the past or when a person is in a new relationship. As such, during sex, anxiety may make a man self-conscious, which makes it quite difficult for him to have an erection.
Depression: Feeling depressed or extremely sad because of any kind of issue such as a failed relationship, a poor career or recalling some past trauma may cause erectile dysfunction. Depression makes a person tired , thereby lowering his sex drive. The medicines used for treating depression may also lower libido,as a result of which a man may fail to get an erection.
Low Self-esteem: Having a low or a negative self-esteem may cause performance anxiety. A person is likely to be worried about how he will perform in bed. Low self-esteem may arise from factors related to body image, past experiences and from an underlying feeling of guilt.
Lack of Interest: Many conditions may divert a man’s interest from having sex. The lowering of libido will make it difficult for a man to get an erection and may lead to impotence. Such lack of interest may be on account of relationship issues, certain medications or because of ageing. Anger may also make a person lose interest in having sex.
If your sex life is getting hampered because of any such psychological factors, you must visit a doctor for seeking advice, suggestions and treatment. This will allow you to uncover and resolve the impotence-related problems, thereby letting you enjoy a healthy relationship with your partner in bed. If you wish to discuss about any specific problem, you can consult a Sexologist.
Adverse respiratory events (AREs) are leading causes of post-operative morbidity and mortality. Anesthesia is the use of medicine to prevent or reduce the feeling of pain or sensation during surgery or other painful procedures (such as getting stitches). Giving as an injection or through inhaled gases or vapours, different types of anesthesia affect the nervous system in various ways by blocking nerve impulses and, therefore, pain.
Anesthesia can help control your breathing, blood pressure, blood flow, and heart rate. It may be used to:
Adverse Respiratory Events (ARE)
Adverse outcomes of such events are fatal and lead to Death & Brain Damage. Three mechanisms of injury are reported to account for highest adverse respiratory events:
Inadequate Ventilation: Insufficient Gas Exchange can produce the adverse outcome. Esophageal Intubation: Incubation between the two sides of the esophagus inadvertently.
Difficult tracheal intubation: Tracheal Intubation is the placement of a flexible plastic tube into the trachea (windpipe) to maintain an open airway. It is performed facilitate ventilation of lungs in severely ill, anesthetized patients.
Other’s are as listed below:
Residual neuromuscular blockade is an important postoperative complication associated to the use of neuromuscular blocking drugs and is commonly observed in the post-anesthesia care unit (PACU) after non-depolarizing neuromuscular blocking agents (NMBAs) are administered intra-operatively. Incomplete neuromuscular recovery can be minimized with acceleromyography monitoring. The risk of adverse respiratory events during early recovery from anesthesia can be reduced by intra-operative acceleromyography use.
Reintubation is a serious adverse respiratory event and the consequences include increased cardiac and respiratory complications, prolonged length of stay at the PACU, intensive care unit (ICU) and hospital, prolonged mechanical ventilator support, higher costs, and increased mortality. Overweight and obesity have also been identified as risk factors for postoperative respiratory complications. Most adverse respiratory events are considered preventable with improved monitoring such as:
Closed observation of the clinical factors and appropriate monitoring by well trained people are factors necessary to prevent adverse outcome. If you wish to discuss about any specific problem, you can consult a General Surgeon.
Glucose is the primary ingredient within the body which is turned into an energy source. This is what we use when we move, walk or make the slightest movements. To metabolize glucose into energy, your body needs insulin, which is a hormone produced within the pancreas. However, if the body doesn't react to the insulin or the pancreas is unable to produce enough, glucose cannot be converted into energy and thus results in type 2 diabetes.
Symptoms of type 2 diabetes
Causes of Type 2 diabetes
Some of the most common causes of Type 2 diabetes could be:
Reverse Diabetes
There three major factors that can help you prevent and reverse pre- and type II diabetes: proper diet and appropriate nutritional and herbal supplementation, exercise, and weight management.