Plasminogen Activator Inhibitor-1 Test

Plasminogen activator inhibitor-1 (PAI-1) test is prescribed in patients experiencing bleeding disorders, most of which are associated with surgery or trauma. The test identifies the presence of (PAI-1) antigen in the blood. Your doctor may also order this test if you show signs and symptoms of inflammation, diabetes, obesity, cancer, atherosclerosis, atherothrombosis, or pregnancy. The test may also be ordered if you underwent a surgery recently.

No special preparation is required for this test. You do not have to fast before giving your sample. You may still ask your doctor if you have any concerns regarding this test.

The test helps identify deficiency or heredity elevation of plasminogen activator inhibitor type 1 in blood. It is also used for diagnosing impaired fibrinolysis and thrombosis. If the test shows low levels or absence of PAI-1, it implies chronic bleeding diathesis. Increased PAI-1 activity is seen in patients with diabetes, inflammation, obesity, cancer, atherothrombosis, and atherosclerosis. It is also high in pregnancy or during postoperative period.

Since the test measures the amount of a particular antigen in plasma, you will have to give a blood sample. Blood is usually withdrawn from the upper arm. An elastic band is tied around the arm to make the veins visible. A needle is then inserted and blood is collected. This test is slightly painful. Applying pressure on the needle site after the sample is taken helps stop blood flow.