Allopurinol

Allopurinol is widely used in treatment of gout and kidney stones. It is also used to treat secondary hyperuricemia which may occur during treatment of tumors or leukemia, and to prevent recurrent calcium oxalate calculi. This medication works by blocking xanthine oxidase which reduces the amount of uric acid made by the body.

You should not take this drug if you are allergic to it. This medicine belongs to a class of drugs called xanthine oxidase inhibitors. Increased uric acid levels are the major cause for gout and kidney problems. Tell your doctor if:

• You are pregnant or planning to conceive.
• You are breastfeeding a baby.
• You suffer from kidney disease, liver disease, diabetes, high blood pressure.
• You are receiving any chemotherapy.

The dosage of this medication will be based on your age, medical condition and your response to the treatment. At high dosages, it is a theoretical possibility that oxypurinol stones could be formed but no record of such occurrence in overdose exists.

The usual dose is 100mg, administered once everyday. It is advised to take this medicine after meals. Follow the instructions of your doctor carefully to ensure the medication is effective.

Take as directed. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake) to avoid possible adverse renal problems. While using this medication, do not use alcohol, other prescription or OTC medications, or vitamin substances without consulting prescriber.

You may experience drowsiness (use caution when driving or engaging in tasks requiring alertness until response to drug is known); nausea, vomiting, or heartburn (small frequent meals, frequent mouth care, chewing gum, or sucking lozenges may help); hair loss (reversible).

Report skin rash or lesions; painful urination or blood in urine or stool; unresolved nausea or vomiting; numbness of extremities; pain or irritation of the eyes; swelling of lips, mouth, or tongue; unusual fatigue; easy bruising or bleeding; yellowing of skin or eyes; or any change in color of urine or stool.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Nephrologist before using this medicine.

• Gout

• Increased Blood Uric Acid

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Nephrologist before using this medicine.

• Hypersensitivity

• Pregnancy

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Nephrologist before using this medicine.

• Rash

• Nausea

• Vomiting

• Renal Failure

• Dyspepsia

• Gynecomastia

• Pancreatitis

• Vasculitis

• Peripheral Neuropathy

• Neuritis

• Bronchospasm

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Nephrologist before using this medicine.

• How long is the duration of effect?

  The effect of this medicine lasts for an average duration of 24 hours.

• What is the onset of action?

  The effect of this medicine can be observed in 2 to 3 days.

• Are there any pregnancy warnings?

  Inadequate data available. Women who are pregnant must consult doctor before using this drug.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  In case of breastfeeding, consult your doctor as it is not recommended to these women.

• Is It safe with alcohol?

  Consult your doctor before consuming alcohol.

• Does this affect kidney function?

  Dose adjustment is needed in patients suffering from renal impairment.

• Does this affect liver function?

  Dose adjustment is needed in patients suffering from hepatic impairment.

• Is it safe to drive while on this medicine?

  Do not drive while consuming this medicine as it causes dizziness and drowsiness.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Nephrologist before using this medicine.

• Are there any missed dose instructions?

  Take the missed dose as soon as you remember. However, if it is almost time for the next scheduled dose then the missed dose should be skipped.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of overdose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Nephrologist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Nephrologist before using this medicine.

Below is the list of medicines, which contains Allopurinol as ingredient

• Ciploric 100 MG Tablet

  Cipla Ltd

• Alinol 10Mg Tablet

  Kivi Labs Ltd

• Alrik 300 MG Tablet

  Cipla Ltd

• Logout 250 MG Capsule SR

  Inga Laboratories Pvt. Ltd

• Zyloric 300 MG Tablet

  Glaxosmithkline Pharmaceuticals Ltd

• Uritas 300 MG Tablet

  Intas Pharmaceuticals Ltd

• Axanthine 300 MG Tablet

  Bioplasma Research Pvt. Ltd.

• Alloric 300 MG Tablet

  Parasol Laboratories

• Ciploric 300 MG Tablet

  Cipla Ltd

• Zyrik 300 MG Tablet

  Cipla Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Nephrologist before using this medicine.

This medicine belongs to the class xanthine oxidase inhibitor. It works by inhibiting xanthine oxidase enzyme thus inhibits the conversion of hypoxanthine to xanthine to uric acid without affecting the enzymes involved in purine and pyrimidine synthesis.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Nephrologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Lab Test

  Information not available.

• Interaction with Medicine

  Concomitant use of this medicine along with the following must be avoided due to increased toxicity includes:

  • Inhibits metabolism of azathioprine and mercaptopurine (reduce to 1/3 or 1/4 of usual dose).
  • Use with ampicillin or amoxicillin may increase the incidence of skin rash.
  • Urinary acidification with large amounts of vitamin C may increase kidney stone formation.
  • Thiazide diuretics enhance toxicity, monitor renal function; thiazide diuretics and captopril (possibly other ACE inhibitors) may increase risk of hypersensitivity.
  • Vidarabine neurotoxicity may be enhanced.
  • Cyclosporine levels may be increased.
  • Hepatic iron uptake may be increased with iron supplements.
  • Allopurinol prolongs half-life of oral anticoagulants; allopurinol increases serum half-life of theophylline; allopurinol may compete for excretion in renal tubule with chlorpropamide and increases chlorpropamide's serum half-life.

• Interaction with Food

  It should be administered after meals with plenty of fluid

• Interaction with Disease

  Do not use to treat asymptomatic hyperuricemia. Discontinue at first signs of rash; reduce dosage in renal insufficiency, reinstate with caution in patients who have had a previous mild allergic reaction, use with caution in children; monitor liver function and complete blood counts before initiating therapy and periodically during therapy, use with caution in patients taking diuretics concurrently. Risk of skin rash may be increased in patients receiving amoxicillin or ampicillin. The risk of hypersensitivity may be increased in patients receiving thiazides, and possibly ACE inhibitors.

• Ques : What is Allopurinol?

  Ans : It is widely used in treating gout and kidney stones.

• Ques : How long do I need to use Allopurinol before I see improvement in my condition?

  Ans : In most of the cases, the average time taken by this medication to reach its peak effect is around 1 day to 1 week. Please consult your doctor for the time period you need to use this medication.

• Ques : At what frequency do I need to use Allopurinol?

  Ans : This medication is generally used once or twice a day. It is advised to consult your doctor before the usage, as the frequency also depends on the patient's condition.

• Ques : Should I use Allopurinol empty stomach, before food or after food?

  Ans : This medication is advised to be consumed orally. If you take it on an empty stomach, it might upset the stomach. Please consult the doctor before using it.

• Ques : What are the instructions for the storage and disposal of Allopurinol?

  Ans : It should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

• Ques : What is the appropriate amount of hydration with Allopurinol?

  Ans : It is important to intake at least 2 liters of water while taking this medication for the increased urine output and prevention of kidney stones.

• Ques : How does Allopurinol interact in patients with a history of bone marrow suppression?

  Ans : Allopurinol tends to decrease the production of blood cells which increases the risk of infection. Hence, a patient with bone marrow suppression should be closely monitored while taking this medication. Frequent tests should be done to notice the alteration in blood cells.

• Ques : How is Allopurinol administered?

  Ans : Allopurinol can be administered orally as well as an injection.

• Ques : How long does Allopurinol take to treat gout?

  Ans : Allopurinol may take up to 6 weeks or the effective treatment of gout. A patient may experience gout attacks in the first two weeks while taking medication.

• Allopurinol-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 2 June 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/allopurinol

• Allopurinol-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 2 June 2022].Available from:

  https://go.drugbank.com/drugs/DB00437

• ALLOPURINOL Tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 2 June 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=ALLOPURINOL