Amikacin

Amikacin is prescribed to treat a variety of bacterial infections of lungs, skin, abdomen, and blood caused by E.coli, Streptococci, and Enterococci. It is also used to treat bone infections, respiratory tract infections, endocarditis, and septicemia.

This medicine is known to cause serious kidney problems and hearing problems, especially in the elderly population. Do not take this medicine if you have a known allergy to it. Tinnitus or vertigo may be indications of vestibular injury and impending bilateral irreversible damage which may occur, which is a possible adverse reaction of this medication.

Inform your doctor if you feel fullness in the head, change in urinary pattern, the sign of opportunistic infections like sore throat, white plague, mouth sores, chills or vaginal discharge. Be cautious if you have renal damage, as this medicine may worsen your condition. But this effect is usually reversible.

Symptoms of overdose include ototoxicity, nephrotoxicity, and neuromuscular toxicity. Treatment of choice following a single acute overdose appears to be the maintenance of good urine output of at least 3 mL/kg/hour.

Dialysis is of questionable value in the enhancement of aminoglycoside elimination. If required, hemodialysis is preferred over peritoneal dialysis in patients with normal renal function.

Dose and/or frequency of administration must be monitored and modified in patients with renal impairment; drug should be discontinued if signs of ototoxicity, nephrotoxicity, or hypersensitivity occur.

Ototoxicity is proportional to the amount of drug given and the duration of treatment; tinnitus or vertigo may be indications of vestibular injury and impending bilateral irreversible damage; renal damage is usually reversible.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Intra-Abdominal Infections

• Pneumonia

• Bacteremia

• Respiratory Tract Infection

• Endocarditis

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Allergy

• Impaired Kidney Function

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Blurred Vision

• Dizziness

• Difficulty In Breathing

• Hearing Loss

• Muscle Pain

• Unusual Tiredness And Weakness

• Skin Rash

• Vomiting

• Neurotoxicity

• Ototoxicity

• Nephrotoxicity

• Headache

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• How long is the duration of effect?

  This medicine is excreted in urine and its effect lasts for a duration of 8 to 12 hours.

• What is the onset of action?

  The peak effect of this medicine can be observed in 45 to 120 minutes after Intramuscular administration.

• Are there any pregnancy warnings?

  This medicine is not recommended for pregnant women.

• Is it habit forming?

  No habit forming tendency has been reported.

• Are there any breast-feeding warnings?

  Sufficient informationis not available on whether this medicine is excreted in breast milk.

• Does this affect kidney function?

  Dose adjustment is needed. If you have renal impairment, consult your doctor before taking this medication.

• Does this affect liver function?

  No related information is available. Kindly consult your doctor before taking this medication.

• Is It safe with alcohol?

  Consumption of this medicine is found to be safe and does not cause any harmful side effects.

• Is it safe to drive while on this medicine?

  This medicine affects the consciousness of the patient. Hence patient must avoid driving while taking this medicine.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Are there any missed dose instructions?

  Take the missed dose as soon as possible. If it is almost time for the next dose, skip the dose and follow the regular schedule.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Below is the list of medicines, which contains Amikacin as ingredient

• Acil 500 MG Injection

  Dr. Johns Laboratories Pvt Ltd

• Amee 250 MG Injection

  Zydus Cadila

• Amiject 500 MG Injection

  Alkem Laboratories Ltd

• Amikacin 500 MG Injection

  Cadila Pharmaceuticals Ltd

• Amiva 500 MG Injection

  Veritaz Healthcare Ltd

• Cecef 1000 MG Injection

  Crest Pharma Pvt Ltd

• Macmika 100 MG Injection

  Macleods Pharmaceuticals Pvt.Ltd

• Macmika 500 MG Injection

  Macleods Pharmaceuticals Pvt.Ltd

• Micin 500 MG Injection

  Fdc Ltd

• Mika Best 500 MG Injection

  Bestochem Formulations (I) Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

This medication belongs to the group of Aminoglycosides. It works by irreversibly binding to 30S ribosomal subunits of susceptible bacteria and inhibits the growth of the bacteria.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Medicine

  Furosemide

  The use of this medication with furosemide or other loop diuretics is not recommended as this combination will increase the risk of kidney injury and hearing loss. Inform the doctor if you are taking either of the medicines. An alternate medicine should be considered based on the clinical condition.

  Ceftriaxone

  The use of this medication with Ceftriaxone or other Cephalosporins will increase the risk of kidney injury. If coadministration is needed monitoring of body weight and frequency of urination is necessary. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition.

  Aspirin

  Use of this medication with NSAIDs like Aspirin will increase the risk of kidney injury. If coadministration is needed monitoring of body weight and frequency of urination is necessary. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition.

  Ethinyl Estradiol

  The desired effect of contraceptive pills will not achieve if these medicines are taken together. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition.

  Others

  Must avoid concomitant use of these medicines if you are taking Amikacin:

  • Decreased effect of aminoglycoside: High concentrations of penicillins and/or cephalosporins ( in vitro data)
  • Increased toxicity of aminoglycoside: Indomethacin I.V., amphotericin, loop diuretics, vancomycin, enflurane, methoxyflurane; increased toxicity of depolarizing and nondepolarizing neuromuscular blocking agents and polypeptide antibiotics with administration of aminoglycosides

• Interaction with Disease

  Myasthenia Gravis

  Inform the doctor if you have any muscular disorders like Myasthenia Gravis or Parkinsonism since this medicine may increase the muscle weakness. An alternate medicine should be considered based on the clinical condition.

  Impaired Kidney Function

  Inform the doctor if you have any kidney disease or if you have been taking NSAIDs for a long time. An alternate medicine should be considered based on the clinical condition.

• Interaction with Food

  Information not available.

• Ques : What is Amikacin?

  Ans : This medication is used to treat a variety of bacterial infections of lungs, skin, abdomen and blood caused by E.coli, Streptococci, and Enterococci. This medicine performs its action by stopping bacterial growth and preventing the synthesis of essential proteins required by bacteria to carry out vital functions.

• Ques : What are the uses of Amikacin?

  Ans : Amikacin is used for the treatment and prevention from conditions such as bacterial infections. Apart from these, it can also be used to treat conditions like Intra-abdominal Infection, Pneumonia, Bacteremia, and Bone and Joint infections. The patient should inform the doctor about any ongoing medications and treatment before using Amikacin to avoid undesirable effects.

• Ques : What are the Side Effects of Amikacin?

  Ans : Amikacin has some commonly reported side effects. These side effects may or may not occur always and some of them are rare but severe. This is not a complete list and if you experience any of the below-mentioned side effects, contact your doctor immediately. Some side effects of Amikacin are Blurred Vision, Dizziness, Difficulty In Breathing, Hearing Loss, Muscle Pain, Unusual Tiredness, Weakness, Skin Rash, Vomiting, Neurotoxicity, Ototoxicity, Nephrotoxicity and Headache.

• Ques : What are the instructions for storage and disposal Amikacin?

  Ans : Amikacin should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Ques : How long do I need to use Amikacin before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions. The normal course of medication with Amikacin is around 7 to 10 days. Please do not change the dose of the drug on your own and consult your doctor.

• Ques : At what frequency do I need to use Amikacin?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Amikacin empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : Is Amikacin safe?

  Ans : Amikacin is safe to use in dose and duration prescribed by the healthcare expert. It should be taken exactly as instructed and make sure to not skip any dose.

• Ques : Can I take a higher than the recommended dose of this medicine?

  Ans : Amikacin should be used only in the prescribed dosage. An overdosage of this salt can enhance the risk of having an adverse effect. It also increases the risks of side effects.

• Ques : Can I stop taking Amikacin when I feel better?

  Ans : It is suggested not to stop taking this drug without informing your doctor. Please make sure that you complete the full course of medication even if you feel better, otherwise, this can worsen your condition.

• Ques : Can I take alcohol while on Amikacin?

  Ans : You should limit the consumption of alcohol during the course of treatment. It is because alcohol consumption can worsen your condition as it causes dizziness and sleepiness.

• Amikacin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 13 December 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/amikacin

• Amikacin- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 13 December 2019]. Available from:

  https://www.drugbank.ca/drugs/DB00479

• Amikacin 250 mg/ml Injection- EMC [Internet] medicines.org.uk. 2015 [Cited 13 December 2019]. Available from:

  https://www.medicines.org.uk/emc/product/3784