Amikacin 500 MG Injection

This medication is prescribed to treat a variety of bacterial infections of lungs, skin, abdomen, and blood caused by E.coli, Streptococci, and Enterococci. It is also used to treat bone infections, respiratory tract infections, endocarditis, and septicemia.

This medicine is known to cause serious kidney problems and hearing problems, especially in the elderly population. Do not take this medicine if you have a known allergy to it. Tinnitus or vertigo may be indications of vestibular injury and impending bilateral irreversible damage which may occur, which is a possible adverse reaction of this medication.

Inform your doctor if you feel fullness in the head, change in urinary pattern, the sign of opportunistic infections like sore throat, white plague, mouth sores, chills or vaginal discharge. Be cautious if you have renal damage, as this medicine may worsen your condition. But this effect is usually reversible.

The medication works by preventing the synthesis of certain proteins that are required for the growth of bacteria. However, Use of this medication can lead to complications related to kidney and hearing problems in elderly patients. The medication should be avoided if you have a known allergy to it.

Some of the side effects associated with this injection are Hearing loss, muscle pain, frequent urination, Unusual tiredness & weakness, Difficulty in breathing and blurred vision.

The medication does not excrete through breast milk hence it can be used during breastfeeding, however, pregnant women should consult a doctor before using it to know the risks associated with the injection.

Symptoms of overdose include ototoxicity, nephrotoxicity, and neuromuscular toxicity. Treatment of choice following a single acute overdose appears to be the maintenance of good urine output of at least 3 mL/kg/hour.

Dialysis is of questionable value in the enhancement of aminoglycoside elimination. If required, hemodialysis is preferred over peritoneal dialysis in patients with normal renal function.

Dose and/or frequency of administration must be monitored and modified in patients with renal impairment; drug should be discontinued if signs of ototoxicity, nephrotoxicity, or hypersensitivity occur.

Ototoxicity is proportional to the amount of drug given and the duration of treatment; tinnitus or vertigo may be indications of vestibular injury and impending bilateral irreversible damage; renal damage is usually reversible.

• Intra-Abdominal Infections

• Pneumonia

• Bacteremia

• Respiratory Tract Infection

• Endocarditis

• Allergy

• Impaired Kidney Function

• Blurred Vision

• Dizziness

• Difficulty In Breathing

• Hearing Loss

• Muscle Pain

• Unusual Tiredness And Weakness

• Skin Rash

• Vomiting

• Neurotoxicity

• Ototoxicity

• Nephrotoxicity

• Headache

• How long is the duration of effect?

  This medication is excreted in urine and its effect lasts for a duration of 8 to 12 hours.

• What is the onset of action?

  The maximum effect of this medication is usually observed in 45 to 120 minutes after it is being injected into the muscles.

• Are there any pregnancy warnings?

  This medication is not recommended for pregnant women. Doctor consultation is necessary.

• Is it habit forming?

  No habit forming tendency has been reported for this medication.

• Are there any breast-feeding warnings?

  The medication is not known to excrete through human breast milk, it is still advised to consult a medical expert before using it.

• Is It safe with alcohol?

  Consumption of this medicine is found to be safe and does not cause any harmful side effects.

• Is it safe to drive while on this medicine?

  This medicine affects the consciousness of the patient. Hence patient must avoid driving while taking this medicine.

• Does this affect kidney function?

  Dose adjustment is needed. If you have renal impairment, consult your doctor before taking this medication.

• Does this affect liver function?

  No related information is available. Kindly consult your doctor before taking this medication.

Below is the list of medicines, which have the same composition, strength and form as Amikacin 500 MG Injection , and hence can be used as its substitute.

• Mikacin 500 MG Injection

  Aristo Pharmaceuticals Pvt.Ltd

• Bristokacin 500 MG Injection

  Bms India Pvt. Ltd

• Amee 500 MG Injection

  Zydus Cadila

• Amikef 500 MG Injection

  Lupin Ltd

• Akasyn 500 MG Injection

  Glenmark Pharmaceuticals Ltd

• Are there any missed dose instructions?

  Take the missed dose as soon as possible. If it is almost time for the next dose, skip the dose and follow the regular schedule.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

Amikacin 500 MG Injection belongs to the group of Aminoglycosides. It works by irreversibly binding to 30S ribosomal subunits of the susceptible bacteria and inhibits the growth of the bacteria.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Medicine

  Do not use this injection in combination with Ceftriaxone, Ethinyl Estradiol, Furosemide, Aspirin and Adefovir.

  Must avoid concomitant use of these medicines if you are taking Amikacin:

  • Decreased effect of aminoglycoside: High concentrations of penicillins and/or cephalosporins ( in vitro data).
  • Increased toxicity of aminoglycoside: Indomethacin I.V., amphotericin, loop diuretics, vancomycin, enflurane, methoxyflurane; increased toxicity of depolarizing and nondepolarizing neuromuscular blocking agents and polypeptide antibiotics with administration of aminoglycosides.

• Interaction with Disease

  • Myasthenia Gravis: Inform the doctor if you have any muscular disorders like Myasthenia Gravis or Parkinsonism since this medicine may increase muscle weakness. An alternate medicine should be considered based on the clinical condition.
  • Impaired Kidney Function: Inform the doctor if you have any kidney disease or if you have been taking NSAIDs for a long time. An alternate medicine should be considered based on the clinical condition.

• Ques : What is Amikacin 500 MG Injection?

  Ans : This medication is used to treat a variety of bacterial infections of lungs, skin, abdomen and blood caused by E.coli, Streptococci, and Enterococci. This medicine performs its action by stopping bacterial growth and preventing the synthesis of essential proteins required by bacteria to carry out vital functions.

• Ques : What are the uses of Amikacin 500 MG Injection?

  Ans : Amikacin 500 MG Injection is used for the treatment and prevention from conditions such as bacterial infections. Apart from these, it can also be used to treat conditions like Intra-abdominal Infection, Pneumonia, Bacteremia, and Bone and Joint infections. The patient should inform the doctor about any ongoing medications and treatment before using Amikacin 500 MG Injection to avoid undesirable effects.

• Ques : What are the Side Effects of Amikacin 500 MG Injection?

  Ans : Amikacin 500 MG Injection has some commonly reported side effects. These side effects may or may not occur always and some of them are rare but severe. This is not a complete list and if you experience any of the below-mentioned side effects, contact your doctor immediately. Some side effects of Amikacin 500 MG Injection are Blurred Vision, Dizziness, Difficulty In Breathing, Hearing Loss, Muscle Pain, Unusual Tiredness, Weakness, Skin Rash, Vomiting, Neurotoxicity, Ototoxicity, Nephrotoxicity and Headache.

• Ques : What are the instructions for storage and disposal Amikacin 500 MG Injection?

  Ans : Amikacin 500 MG Injection should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Ques : How long do I need to use Amikacin 500 MG Injection before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions. The normal course of medication with Amikacin 500 MG Injection is around 7 to 10 days. Please do not change the dose of the drug on your own and consult your doctor.

• Ques : At what frequency do I need to use Amikacin 500 MG Injection?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Amikacin 500 MG Injection empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : Is Amikacin 500 MG Injection safe?

  Ans : Amikacin 500 MG Injection is safe to use in dose and duration prescribed by the healthcare expert. It should be taken exactly as instructed and make sure to not skip any dose.

• Ques : Can I take a higher than the recommended dose of this medicine?

  Ans : Amikacin 500 MG Injection should be used only in the prescribed dosage. An overdosage of this salt can enhance the risk of having an adverse effect. It also increases the risks of side effects.

• Ques : Can I stop taking Amikacin 500 MG Injection when I feel better?

  Ans : It is suggested not to stop taking this drug without informing your doctor. Please make sure that you complete the full course of medication even if you feel better, otherwise, this can worsen your condition.

• Ques : Can I take alcohol while on Amikacin 500 MG Injection?

  Ans : You should limit the consumption of alcohol during the course of treatment. It is because alcohol consumption can worsen your condition as it causes dizziness and sleepiness.

• Amikacin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 13 December 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/amikacin

• Amikacin- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 13 December 2019]. Available from:

  https://www.drugbank.ca/drugs/DB00479

• Amikacin 250 mg/ml Injection- EMC [Internet] medicines.org.uk. 2015 [Cited 13 December 2019]. Available from:

  https://www.medicines.org.uk/emc/product/3784