Amlokem M 5/50 Tablet

Amlokem M 5/50 Tablet is used to treat angina, high blood pressure and coronary heart disease. It is recommended in case of heart failure if other medications fail to work. Amlokem M 5/50 Tablet is the key ingredient of this medicine. It increases the myocardial oxygen delivery in patients with vasospastic angina.

Amlokem M 5/50 Tablet belongs to the class of a calcium channel blocker that inhibits calcium ion from entering the slow channels of vascular smooth muscle and myocardium during depolarization. This leads to cause relaxation of coronary vascular smooth muscle and coronary vasodilation.

The medicine should be taken as per the dosage on the prescription. Overdosage of the drug can lead to complications. Depending on the effects the drug has on a patient, the doctor may make variations to the dosage.

The medicine may not be safe to use during pregnancy or breastfeeding. Dosage should be low for elderly people and for those with liver problems. If you have heart problems then intake of Amlokem M 5/50 Tablet may increase your health problems.

The primary cardiac symptoms of calcium blocker overdose includes hypotension and bradycardia. The hypotension is caused by peripheral vasodilation, myocardial depression, and bradycardia. Bradycardia results from sinus bradycardia, second- or third-degree atrioventricular block, or sinus arrest with junctional rhythm.

Intraventricular conduction is usually not affected so QRS duration is normal (verapamil does prolong the P-R interval and bepridil prolongs the Q-T and may cause ventricular arrhythmias, including torsade de pointes).

In a few reported cases, overdose with calcium channel blockers has been associated with hypotension and bradycardia, initially refractory to atropine but becoming more responsive to this agent when larger doses (approaching 1 gram per hour for more than 24 hours) of calcium chloride was administered.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Hypertension

• Angina Pectoris

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Allergy

• Cardiogenic Shock

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Peripheral Edema

• Flushing

• Palpitations

• Headache

• Rash

• Pruritus

• Sexual Dysfunction

• Nausea

• Abdominal Pain

• Dyspepsia

• Gingival Hyperplasia

• Muscle Cramps

• Weakness

• Shortness Of Breath

• Hypotension

• Syncope

• Insomnia

• Weight Gain

• Flatulence

• Constipation

• Vertigo

• Urticaria

• Agitation

• Gastritis

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• How long is the duration of effect?

  This effect of this medicine lasts for a duration of approximately 24 hours.

• What is the onset of action?

  The peak effect of this medicine can be observed in 6 to 12 hours.

• Are there any pregnancy warnings?

  Teratogenic and embryotoxic effects have been demonstrated in small animals. No well controlled studies have been conducted in pregnant women. Use in pregnancy only when clearly needed and when the benefits outweigh the potential hazard to the fetus.

• Is it habit forming?

  No habit forming tendency has been reported.

• Are there any breast-feeding warnings?

  Clear data is not available on the use of this medicine in breastfeeding women. This medicine should be used only if clearly needed and no other safer alternative is available.

• Does this affect liver function?

  Dose adjustment is needed in case of hepatic impairment.

• Does this affect kidney function?

  No relevant information is available.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• Missed Dose instructions

  The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of overdose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

Amlokem M 5/50 Tablet works by inhibiting calcium ion from entering the "slow channels" or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarization, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation; increases myocardial oxygen delivery in patients with vasospastic angina.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Consumption of alcohol should be avoided while taking this medicine, especially when you start taking the medicine or a change its dosage. Symptoms like headache, dizziness, change in pulse or heart rate should be reported to the doctor.

• Interaction with Lab Test

  Information not available.

• Interaction with Medicine

  Carbamazepine

  The desired effect of Amlokem M 5/50 Tablet will not be achieved if taken with carbamazepine. Inform the doctor if you are on either of the medicines. Frequent monitoring of blood pressure is necessary. An alternate medicine or suitable dose adjustments are to be made based on the clinical condition.

  Dexamethasone

  The desired effect of Amlokem M 5/50 Tablet will not be achieved if taken with dexamethasone. This interaction is more likely to happen if dexamethasone is taken for more than a week. Inform the doctor if you are on either of the medicines. Frequent monitoring of blood pressure is necessary. An alternate medicine or suitable dose adjustments are to be made based on the clinical condition.

  Itraconazole

  Itraconazole may increase the concentration of Amlokem M 5/50 Tablet and may cause serious adverse effects such as fluid retention, irregular heart rhythm, and low blood pressure. Inform the doctor if you are on either of the medicines. Frequent monitoring of blood pressure is necessary. An alternate medicine or suitable dose adjustments are to be made based on the clinical condition.

  Rifampin

  The desired effect of Amlokem M 5/50 Tablet will not be achieved if taken with rifampin. Inform the doctor if you are on either of the medicines. Frequent monitoring of blood pressure is necessary. An alternate medicine or suitable dose adjustments are to be made based on the clinical condition.

• Interaction with Disease

  Hypotension

  Amlokem M 5/50 Tablet is not recommended in patients suffering from hypotension or cardiogenic shock as it further reduces the blood pressure.

  Increased angina and/or MI has occurred with initiation or dosage titration of calcium channel blockers. Use caution in severe aortic stenosis. Use caution in patients with severe hepatic impairment. Safety and efficacy in children have not been established. Dosage titration should occur after 7-14 days on a given dose.

• Interaction with Food

  Consumption of grapefruit juice is not recommended as it increases the concentration of Amlokem M 5/50 Tablet. Inform the doctor if you experience dizziness, headache, swelling of hands and feet is necessary.

• Ques : What is Amlokem M 5/50 Tablet?

  Ans : This medicine performs its action by promoting blood flow in the body. It is also used to avoid muscle to contract and coronary atherosclerosis.

• Ques : What are the uses of Amlokem M 5/50 Tablet?

  Ans : It is used for the treatment and prevention of conditions and symptoms of diseases like Angina Pectoris and Hypertension.

• Ques : How long do I need to use Amlokem M 5/50 Tablet before I see improvement in my condition?

  Ans : This drug is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use Amlokem M 5/50 Tablet?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Amlokem M 5/50 Tablet empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : What are the instructions for the storage and disposal of Amlokem M 5/50 Tablet?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Also, keep this drug out of reach of children.

• Ques : How long does it take for Amlokem M 5/50 Tablet to work?

  Ans : It starts working on the day it is taken. However, it may take weeks to see the full effect. You should continue taking the medicine even if you feel better or if you do not notice any considerable difference.

• Ques : Does Amlokem M 5/50 Tablet cause itching?

  Ans : Yes, it might cause itching in some patients, though it is a rare side effect. In case of severe itching, you must take medical help.

• Ques : Should I take Amlokem M 5/50 Tablet in the morning or at night?

  Ans : This drug can be taken at any time in a day. Usually, it is advised to be taken in the morning, but your doctor may advise you to take it in the evening as well.

• Ques : For how long do I need to take Amlokem M 5/50 Tablet?

  Ans : Consume this drug for as long as your doctor has prescribed. Do not stop the consumption of this drug without doctor’s permission.

• Ques : Is Amlokem M 5/50 Tablet a beta-blocker?

  Ans : No, this medication is not a beta-blocker. It belongs to a class of medicines known as calcium channel blockers. It helps in lowering the blood pressure by relaxing the blood vessels so that blood can easily flow through the blood vessels.

• Ques : What are the serious side effects of Amlokem M 5/50 Tablet?

  Ans : Side effects of this medication include yellowing of skin, nausea, vomiting, and loss of appetite), pancreatitis (severe stomach pain, nausea, and vomiting), and recurrent chest pain which may be indicative of a heart attack.

• Amlodipine- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 23 Nov 2021]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/amlodipine

• Amlodipine 5 mg tablets- EMC [Internet]. www.medicines.org.uk. 2018 [Cited 23 Nov 2021]. Available from:

  https://www.medicines.org.uk/emc/product/6075/smpc

• AMLODIPINE- amlodipine besylate tablet- Daily Med [Internet]. dailymed.nlm.nih.gov. 2008 [Cited 23 Nov 2021]. Available from:

  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b52e2905-f906-4c46-bb24-2c7754c5d75b