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Overview

Amphotret 50mg Injection

Manufacturer :  Bharat Serums & Vaccines Ltd
Medicine Composition :  Amphotericin B
Prescription vs OTC : Prescription by Doctor required

About Amphotret 50mg Injection

Being an antifungal medication, Amphotret 50mg Injection helps in killing fungi by destroying the fungal cell membrane. It is given as an injection under the supervision of a doctor. Some of the side effects may include rash, chills, headache, and tiredness during the initial days of the treatment, but these may fade away with time.

You are advised to consult the doctor immediately if you notice pain or blood during urination or trouble in breathing or swelling in the face. Sometimes, your medical practitioner may ask you for regular blood tests to monitor your blood sugar, potassium, magnesium, and kidney function. If you are planning to conceive or you are a pregnant woman then immediately consult the doctor before taking this injection.

Amphotret 50mg Injection is also used in fungal infection in patients with bone marrow transplantation, amebic meningoencephalitis, ocular aspergillosis (intraocular injection), candidal cystitis (bladder irrigation), chemoprophylaxis (low-dose I.V.), immunocompromised patients at risk of aspergillosis (intranasal/nebulized), refractory meningitis (intrathecal), coccidioidal arthritis (intra-articular/I.M.).

Anaphylaxis has been reported with other amphotericin B-containing drugs. During the initial dosing, the drug should be administered under close clinical observation. Avoid additive toxicity with other nephrotoxic drugs.

Drug-induced renal toxicity usually improves with interrupting therapy, decreasing dosage, or increasing dosing interval. I.V. amphotericin is used primarily for the treatment of patients with progressive and potentially fatal fungal infections.

Use Amphotret 50mg Injection with caution in patients with decreased renal function. Pulmonary reactions may occur in neutropenic patients receiving leukocyte transfusions; separation of the infusions as much as possible is advised.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

    What are the uses of Amphotret 50mg Injection

    • Serious Fungal Infections

    • Kala-Azar

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

    What are the contraindications of Amphotret 50mg Injection ?

    • Hypersensitivity

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

    What are the side effects of Amphotret 50mg Injection ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

    Key highlights of Amphotret 50mg Injection

    • How long is the duration of effect?

      It may differ from person to person. You should consult about it with the doctor to get the suitable dosage prescriptions. Usually, it is about 15-48 hours, maximum about 15 days.

    • What is the onset of action?

      The action of this drug is initiated within 1 hour following a 4- to 6-hour dose.

    • Are there any pregnancy warnings?

      Pregnant women are advised to consult a doctor before consuming this drug.

    • Is it habit forming?

      No, the medicine is not habit-forming or addictive.

    • Are there any breast-feeding warnings?

      Lactating mothers are advised to take medical help before consuming this medication.

    • Is it safe to drive while on this medicine?

      It is advisable that you do not indulge in driving while on this medication since there is a possibility of you experiencing drowsy or calm and thus affecting your driving skills.

    • Does this affect kidney function?

      No relevant information is available.

    • Does this affect liver function?

      No relevant information is available.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

    What are the substitutes for Amphotret 50mg Injection ?

    Below is the list of medicines, which have the same composition, strength and form as Amphotret 50mg Injection , and hence can be used as its substitute.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      It is advisable that you do not miss a dosage since there is just one dose per day. Consume the missed dosage as soon as you remember.

    • Are there any overdose instructions?

      In case of an overdose, make sure that you consult a doctor with immediate effect.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

    Where is the Amphotret 50mg Injection approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

    How does this medication work?

    This medication is an antifungal medication that helps in killing fungi by destroying the fungal cell membrane. It binds to ergosterol altering cell membrane permeability in susceptible fungi and causing leakage of cell components with subsequent cell death.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

      What are the interactions of Amphotret 50mg Injection ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

        test
      • Interaction with Medicine

        • Increased nephrotoxicity: Aminoglycosides, cyclosporine, other nephrotoxic drugs.
        • Potentiation of hypokalemia: Corticosteroids, corticotropin.
        • Increased digitalis and neuromuscular-blocking agent toxicity due to hypokalemia.
        • Decreased effect: Pharmacologic antagonism may occur with azole antifungal agents (eg, miconazole, ketoconazole).
        • Pulmonary toxicity has occurred with concomitant administration of amphotericin B and leukocyte transfusions.

      FAQs about Amphotret 50mg Injection

      • Ques : What are the uses of Amphotret 50mg Injection?

        Ans : Amphotret 50mg Injection is an anti-fungal medication that is used in the treatment of major, life-threatening fungal infections.

      • Ques : How is Amphotret 50mg Injection administered?

        Ans : Amphotret 50mg Injection is administered intravenously.

      • Ques : What is the length of the treatment of Amphotret 50mg Injection?

        Ans : Amphotret 50mg Injection is administered till the time you see an improvement in your health conditions.

      • Ques : How is Amphotret 50mg Injection stored?

        Ans : Amphotret 50mg Injection is stored at room temperature in the dark for 1 week such that there is minimum loss of potency.

      • Ques : Where is Amphotret 50mg Injection legal?

        Ans : Amphotret 50mg Injection is legal in India, Japan, Micronesia, and the USA.

      • Ques : Are there any dietary restrictions with Amphotret 50mg Injection?

        Ans : There are no dietary restrictions to follow with Amphotret 50mg Injection unless prescribed by the doctor.

      • Ques : What are some cautions to take with Amphotret 50mg Injection?

        Ans : it is advised to not use Amphotret 50mg Injection on patients with minor fungal infections with normal neutrophil counts. There is also a risk of an acute infusion reaction, nephrotoxicity, and cardiomyopathy. Hence it should be used with care.

      References

      • Liposomal-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 30 May 2022].Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/liposomal

      • Liposomal-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 30 May 2022].Available from:

        https://go.drugbank.com/drugs/DB00681

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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