Benazepril

Benazepril is primarily prescribed in the treatment of hypertension, either alone or in combination with other antihypertensive agents. Also, it is employed for treating left ventricular dysfunction after myocardial infarction.

Avoid rapid dosage escalation which may lead to renal insufficiency. Hypersensitivity reactions may be seen during hemodialysis with high-flux dialysis membranes (eg, AN69). Deterioration in renal function can occur with initiation.

Anaphylactic reactions can occur. Angioedema can occur at any time during treatment (especially following the first dose). Careful blood pressure monitoring with the first dose (hypotension can occur especially in volume-depleted patients).

Mild hypotension has been the only toxic effect seen with acute overdose. Bradycardia may also occur; hyperkalemia occurs even with therapeutic doses, especially in patients with renal insufficiency and those taking NSAIDs.

Following initiation of essential overdose management, toxic symptom treatment and supportive treatment should be initiated. Hypotension usually responds to I.V. fluids or Trendelenburg positioning.

Take exactly as directed; do not discontinue without consulting prescriber. Take the first dose at bedtime. Take all doses on an empty stomach (30 minutes before or 2 hours after meals). This drug does not eliminate the need for diet or exercise regimen as recommended by the prescriber.

It is advised to follow all directions on your medicine label and package. Tell your medical practitioner about all your medical conditions, allergies, and all medicines you use.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

• Hypertension

• Left Ventricular Dysfunction

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

• Hypersensitivity

• Pregnancy

• Hereditary Angioedema

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

• Dizziness

• Headache

• Fatigue

• Hyperkalemia

• Nausea

• Cough

• Hypotension

• Syncope

• Shock

• Flushing

• Photosensitivity

• Pruritus

• Rash

• Dermatitis

• Alopecia

• Sweating

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

• How long is the duration of effect?

  The effect of this medicine will remain active for 24 hours has been observed after 5-20 mg dose.

• What is the onset of action?

  The effect of this drug is initiated within 1-2 hours after administration of 2-20 mg dose.

• Are there any pregnancy warnings?

  Contraindicated in pregnancy (2nd and 3rd trimesters) as it falls in Type C and D drugs causing fetal effect on the fetus.

• Is it habit forming?

  No, the medicine is not habit-forming or addictive.

• Are there any breast-feeding warnings?

  Lactating mothers are advised to take medical help before using this medication. American Academy of Pediatrics considers compatible with breast-feeding.

• Is it safe to drive while on this medicine?

  It is advisable that you do not indulge in driving while on this medication since there is a possibility of you experiencing drowsy or calm and thus affecting your driving skills.

• Does this affect kidney function?

  Dosage adjustment needed in renal impairment. Kindly consult your doctor before taking this medicine.

• Does this affect liver function?

  No relevant information is available.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

• Are there any missed dose instructions?

  Since Benazepril is used when needed, it is advised to apply the missed dose as soon as you remember. Do not use extra medicine to make up the missed dose.

• Are there any overdose instructions?

  The overdose for this medication is not expected to be dangerous.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

Below is the list of medicines, which contains Benazepril as ingredient

• Amlo B Tablet

  Orchid Chemicals & Pharmaceuticals Ltd

• Amace-Bp Tablet

  Systopic Laboratories Pvt Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

Competitive inhibition of angiotensin I being converted to angiotensin II, a potent vasoconstrictor, through the angiotensin I-converting enzyme (ACE) activity, with resultant lower levels of angiotensin II which causes an increase in plasma renin activity and a reduction in aldosterone secretion.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a General Physician before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Medicine

  Concomitant use of the following drugs must be avoided with Benazepril:

  • Alpha1 blockers: Hypotensive effect increased.
  • Aspirin and NSAIDs may decrease ACE inhibitor efficacy.
  • Diuretics: Hypovolemia due to diuretics may precipitate acute hypotensive events or acute renal failure.
  • Insulin: Risk of hypoglycemia may be increased.
  • Lithium: Risk of lithium toxicity may be increased; monitor lithium levels.
  • Potassium-sparing diuretics or potassium supplements (amiloride, potassium, spironolactone, triamterene): Increased risk of hyperkalemia.
  • Trimethoprim (high dose) may increase the risk of hyperkalemia.

• Interaction with Disease

  Use with caution in hypovolemia; collagen vascular diseases; valvular stenosis (particularly aortic stenosis); hyperkalemia; or before, during, or immediately after anesthesia. Avoid rapid dosage escalation which may lead to renal insufficiency. Use with caution in unilateral renal artery stenosis and pre-existing renal insufficiency.

• Ques : What is Benazepril?

  Ans : Benazepril belongs to a class of medicines known as angio-tensin converting enzymes.

• Ques : What are the uses of the Benazepril?

  Ans : Benazepril is used in treatment of hypertension and prevents stroke and heart attack.

• Ques : How long do I need to use Benazepril before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use Benazepril?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Benazepril empty stomach, before food or after food?

  Ans : This medication should be taken after food with plenty of water or juice in a prescribed dosage.

• Ques : What are the instructions for the storage and disposal of Benazepril?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Ques : Is Benazepril safe for pregnant women?

  Ans : It is not prescribed to pregnant women unless necessary. Consult your doctor beforehand.

• Ques : Is Benazepril safe for breastfeeding women?

  Ans : Breastfeeding women are not suggested to take this medicine unless necessary. Consult your doctor beforehand.

• Ques : Is Benazepril a habit forming drug?

  Ans : No case of addiction has been reported yet.

• Ques : What if I miss a dose of Benazepril?

  Ans : Take it as soon as you remember. However, stick to your routine if it's the time for the next dose. Do not double the dose.