Ceftriaxone

Ceftriaxone is used for treating bacterial infections. It is administered to the patient in the form of an injection. It is used for the treatment of lower respiratory tract infections, skin and skin structure infections, bone and joint infections, intra-abdominal and urinary tract infections, sepsis and meningitis due to susceptible organisms

This medicine is also documented or suspected infection due to susceptible organisms in-home care patients and patients without I.V. line access; treatment of documented or suspected gonococcal infection or chancroid; emergency room management of patients at high risk for bacteremia, periorbital or buccal cellulitis, salmonellosis or shigellosis, and pneumonia of unestablished aetiology (<5 years of age).

Ceftriaxone is also used for the treatment of Lyme disease, depends on the stage of the disease (used in Stage II and Stage III, but not stage I; doxycycline is the drug of choice for Stage I). This medicine belongs to a class of medications known as cephalosporin antibiotics. It works by killing the bacteria. It should always be taken under a doctor’s guidance.

This medicine should always be taken under a doctor’s guidance. It comes in the form of powder which is mixed with liquid and then injected intravenously (into a vein) over a period of 30 to 60 minutes. However, sometimes it is also injected into a muscle. It is usually injected as a single dose. Sometimes it is injected multiple times with a gap of 4 to 14 days between doses.

This medication should always be taken under the supervision of a medical expert. There are also some other precautions you need to take. Firstly check if you have any allergies to any of the ingredients of it. Also, inform the consulting doctor about any prescribed drugs or dietary supplements that you are currently taking to avoid side effects.

Inform your doctor about any history of liver disease, kidney disease or digestive problems. Also if you are pregnant or planning to get pregnant, it is advisable not to take this medication as it might have harmful effects on your baby.

Symptoms of overdose include neuromuscular hypersensitivity, convulsions especially with renal insufficiency; many beta-lactam antibiotics have the potential to cause neuromuscular hyperirritability or seizures.

Hemodialysis may be helpful to aid in the removal of the drug from the blood, otherwise, most treatment is supportive or symptom directed.

This medication is administered I.M. or I.V. Drink 2-3 L fluid/day. If diarrhea occurs, yogurt or buttermilk may help. May cause false-positive test with Clinitest®; use another form of testing.

May interfere with oral contraceptives; additional contraceptive measures are necessary. Report severe, unresolved diarrhea; vaginal itching or drainage; sores in mouth; blood, pus, or mucus in stool or urine; easy bleeding or bruising; unusual fever or chills; rash; or respiratory difficulty.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Lower Respiratory Tract Infection

• Skin And Structure Infection

• Urinary Tract Infection

• Sepsis

• Meningitis

• Gonococcal Infection

• Lyme Disease

• Pneumonia

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Allergy

• Heart Failure

• Neonatal hyperbilirubinemia

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Rash

• Diarrhoea

• Pain

• Pruritus

• Fever

• Chills

• Anemia

• Nausea

• Vomiting

• Headache

• Dizziness

• Flushing

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• How long is the duration of effect?

  The effect of this medicine lasts for 24 hours after the initial action has begun.

• What is the onset of action?

  This medicine has a delayed onset of action owing to its complex mechanism of action.

• Are there any pregnancy warnings?

  This medicine is not recommended for use by women who are pregnant or are planning a pregnancy in near future.

• Is it habit forming?

  No habit forming tendencies were reported.

• Are there any breast-feeding warnings?

  This medicine is not recommended for use in women who are breastfeeding.

• Is It safe with alcohol?

  Consumption of alcohol is found to be safe if taken with this medicine.

• Is it safe to drive while on this medicine?

  This medicine might affect the consciousness of the patient. Thus driving must be avoided while taking this medicine.

• Does this affect kidney function?

  This medicine is found to be safe in patients with kidney disease. Adjustment of dose must not be needed. Kindly consult your doctor before taking it.

• Does this affect liver function?

  Caution must be taken in patients with severe liver disease. Adjustment of dose might be needed. Kindly consult your doctor before taking this medicine.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Are there any missed dose instructions?

  Take the missed dose as soon as you remember. If it is time for the next scheduled dose then the missed dose can be skipped. Do not take two doses within a day to make up for the previous day's missed dose.

• Are there any overdose instructions?

  Contact your doctor immediately if an overdose is suspected. Appropriate supportive measures should be initiated immediately if the symptoms are severe.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• India

• United States

• Japan

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Below is the list of medicines, which contains Ceftriaxone as ingredient

• Cefika S 1000 Mg/500 Mg Injection

  Stadchem Of India

• Accuzon 250 MG Injection

  Macleods Pharmaceuticals Pvt.Ltd

• Accuzon 125 MG Injection

  Macleods Pharmaceuticals Pvt.Ltd

• Accuzon 2000 MG Injection

  Macleods Pharmaceuticals Pvt.Ltd

• Cuxone 1000 MG Injection

  Cubit Healthcare

• Zetri 500 MG Injection

  Novartis India Ltd

• Montaz Injection

  Aristo Pharmaceuticals Pvt Ltd

• Aacef 1000 MG Injection

  Alpic Biotech

• Xucef Xp 1000 Mg/125 Mg Injection

  Allentis Pharmaceuticals Pvt Ltd

• Cefaxone 125 MG Injection

  Lupin Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

This medication belongs to the third-generation cephalosporins. It works by inhibiting bacterial cell wall synthesis by binding to penicillin-binding proteins which would inhibit the growth and multiplication of bacteria.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  You should limit the consumption of alcohol while taking Ceftriaxone. Consult your doctors if any symptoms indicating a fall or rise in blood glucose levels is observed.

• Interaction with Lab Test

  Positive direct Coombs', false-positive urinary glucose test using cupric sulfate (Benedict's solution, Clinitest®, Fehling's solution), false-positive serum or urine creatinine with Jaffé reaction.

• Interaction with Medicine

  Gemfibrozil

  Report the use of either of the medicine to the doctor. You may require an adjustment in the dose of this medication while taking these medicines together. It is advised to keep a regular check on the blood glucose levels while taking these medicines.

  Rifampicin

  Report the use of either of the medicine to the doctor. You may require clinical monitoring and a dose adjustment if these medications are used together. Special caution is advised if the use of Rifampicin is initiated or ended while you are taking it.

  Gatifloxacin

  Report the use of Gatifloxacin to the doctor before Pioglitazone or any other anti-diabetic medicine is prescribed. These medicines can cause some very severe side effects when used together.

  Insulin injection

  Report the use of either of the medicine to the doctor. You may a require a dose adjustment and regular monitoring of blood sugar levels if these medicines are prescribed together. Symptoms of low blood sugar levels like headache, drowsiness, weakness etc should be reported to the doctor.

  Ketoconazole

  Report the use of either of the medicine to the doctor. You may require an adjusted dose of this medication if these medicines are used together. Symptoms of low blood sugar levels like headache, drowsiness, weakness etc should be reported to the doctor.

  Aloe Vera

  Aloe vera should be used with caution while taking this medication or any other anti-diabetic medication. You may require a dose adjustment and regular monitoring of blood sugar levels while taking these medicines together. Symptoms of low blood sugar levels like headache, drowsiness, weakness etc should be reported to the doctor.

  Others

  Concomitent use of the below mentioned medicine must be avoided:

  • Increased effect:Aminoglycosides may result in synergistic antibacterial activity.
  • High-dose probenecid decreases clearance.
  • Increased toxicity:Aminoglycosides increase nephrotoxic potential.

• Interaction with Disease

  Congestive Heart Failure

  Caution should be exercised while administering this medication to patients having heart failure and edema as the risk of worsening of conditions is very high. The lowest recommended dose should be administered to a patient having mild heart failure and edema with clinical monitoring of symptoms. For moderate and severe conditions the use of this medicine is not recommended.

  Bladder Cancer

  The use of this medication is not recommended in patients having an active bladder tumor. The likelihood of worsening of cancer is high and hence other medications should be used in such cases.

  Liver Disease

  This medicine should be used with caution in patients having an increased liver serum levels or an active liver disease. The liver serum levels should be examined before initiating the use of this medicine. Symptoms of liver failure like nausea, vomiting, stomach pain and darkened urine colour while using this medicine should be reported immediately.

  Anemia

  The use of this medication may cause a decrease in the levels of hemoglobin and hence should be administered with caution in anemic patients.

• Interaction with Food

  Information not available.

• Ques : What is Ceftriaxone?

  Ans : This is a drug which is used for treating bacterial infections. It is administered to the patient in the form of an injection.

• Ques : How long do I need to use Ceftriaxone before I see improvement in my condition?

  Ans : This medication is to be taken till the time you see an improvement in your health conditions.

• Ques : At what frequency do I need to use Ceftriaxone?

  Ans : This medication should be taken in the dosage as prescribed by the doctor.

• Ques : Should I use Ceftriaxone empty stomach, before food or after food?

  Ans : This medication should be taken after food in a prescribed dosage.

• Ques : What are the instructions for the storage and disposal of Ceftriaxone?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Ques : Who should not take Ceftriaxone?

  Ans : Ceftriaxone should not be prescribed to people who are allergic to Ceftriaxone or any of its ingredients. Inform your doctor if you have or ever had any problems with your liver, kidneys, gall bladder or any other blood related disorders such as hemolytic anemia. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

• Ques : Is Ceftriaxone safe?

  Ans : Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you. Ceftriaxone is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose.

• Ques : Is Ceftriaxone effective?

  Ans : Ceftriaxone is effective if used in the dose and duration advised by your doctor. Do not stop taking it even if you see improvement in your condition. If you stop using Ceftriaxone too early, the symptoms may return or worsen.

• Ceftriaxone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 23 Nov 2021]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/ceftriaxone

• CEFTRIAXONE- ceftriaxone sodium injection, powder, for solution- Daily Med [Internet]. dailymed.nlm.nih.gov. 2021 [Cited 23 Nov 2021]. Available from:

  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9bcf7973-54fa-487c-99da-db8a92b5e074

• Ceftriaxone 1 g powder for solution for injection or infusion- EMC [Internet]. www.medicines.org.uk. 2019 [Cited 23 Nov 2021]. Available from:

  https://www.medicines.org.uk/emc/product/10604/smpc