Change Tablet

Change Tablet is a combination medication primarily prescribed for treating diarrhoea and/or dysentery. It comprises antibacterial and antiamoebic drugs that fight against parasitic and bacterial infections. It is very effective in treating infectious condition due to its dual-action.

This medication inhibits the production of certain enzymes in the DNA of a bacteria, which are necessary for the survival and growth of this bacterial infections. Therefore, this antibiotic drug fights against bacterial infections by killing the bacteria and inhibiting the process of bacterial cell division.

It is advisable to take this medication only under the strict guidelines of your doctor. Follow this prescription until the course is complete, even if the symptoms disappear. You should not skip a dose and avoid taking an extra tablet to make up for it.

It is possible for some people to experience a few common side effects after taking this medication. Some people are more likely to face harmful side effects if they also suffer from other conditions like brain disorders, seizures, heart conditions, myasthenia gravis, epilepsy, tendonitis, bone disorders and problems of the joints.

It is advisable to inform your doctor about the above-mentioned conditions beforehand if he/she recommends you taking this medicine. It is advisable for pregnant women, women who are breastfeeding and children below 16 years, to avoid taking this antibiotic since it can lead to harmful consequences.

• Infectious Diarrhea

• Dysentery

• Allergy

  Avoid taking Change Tablet if you have a known allergy to this medicine or any other medicines belonging to the class fluoroquinolones.

• Tendinitis Or Tendon Rupture

  Avoid taking this medicineif you have a past history of tendinitis or tendon rupture after using Change Tablet.

• Myasthenia Gravis

  Avoid taking this medicine if you have a past or family history of suffering from Myasthenia Gravis (weakness and rapid fatigue of muscles under voluntary control).

• Abdominal Pain

• Joint Pain

• Black Or Tarry Stools

• Fever With Chills

• Chest Tightness

• Numbness Of The Hands

• Running Nose

• Sneezing

• Memory Impairment

• Nervousness

• Agitation

• Disorientation

• How long is the duration of effect?

  The effect of this medicine lasts for a duration of 12 to 20 hours.

• What is the onset of action?

  The peak effect of this medicine can be observed within 1 to 2 hours of administration of the dose.

• Are there any pregnancy warnings?

  Use of this medicine is not recommended in pregnant women. Use only if clearly needed under the supervision of the doctor.

• Is it habit forming?

  No habit forming tendency has been reported.

• Are there any breast-feeding warnings?

  Use of this medicine is not recommended in women who breastfeed due to the adverse effect on development of the infant's joints. Use only if clearly needed under the supervision of the doctor. Avoid breastfeeding for about 3 to 4 hours to decrease the infant's risk exposure. Monitoring of undesired effects like diarrhea, diaper rash is necessary.

Below is the list of medicines, which have the same composition, strength and form as Change Tablet , and hence can be used as its substitute.

• Eldeflox Oz 200 Mg/500 Mg Tablet

  Elder Pharmaceuticals Ltd

• Cachof 0 200 Mg/500 Mg Tablet

  Cachet Pharmaceuticals Pvt Ltd

• Owin O 200 Mg/500 Mg Tablet

  Alembic Pharmaceuticals Ltd

• Oxo Ord 200Mg/500Mg Tablet

  Ind Swift Laboratories Ltd

• Ofpil O Tablet

  Psychotropics India Ltd

• Zuflo OZ 200mg/500mg Tablet

  Morepen Laboratories Ltd

• Ofrex O 200Mg/500Mg Tablet

  Zydus Cadila

• Woflox Oz 200 Mg/500 Mg Tablet

  Wockhardt Ltd

• Assault Novo 200 Mg/500 Mg Tablet

  Alkem Laboratories Ltd

• Ofloking O Tablet

  Mankind Pharma Ltd

• Are there any missed dose instructions?

  The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of overdose.

This medicine is a combination of Ofloxacin and Ornidazole belonging to the class antibacterial and antiamoebic. Thus the medication follows a dual mechanism to produce its action. Firstly, it works as a bactericidal by inhibiting the bacterial DNA gyrase enzyme, which is essential for DNA replication, transcription, repair, and recombination. This leads to expansion and destabilization of the bacterial DNA and causes cell death. Secondly, it works by seeping into the cells of the bacteria and/or protozoa through diffusion and damaging DNA and other critical biomolecules through the formation of reactive nitro radicals.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Alcohol

  Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Interaction with Lab Test

  Lab

  Information not available.

• Interaction with Medicine

  Corticosteroids

  You may experience pain, swelling, or inflammation in ankle, shoulder, hand, or thumb if these medicines are used together. This interaction is more likely to occur in elderly population who have undergone a kidney or heart transplantation. Replacement of the medicine should be made under the doctor's supervision.

  Escitalopram

  You may experience dizziness, lightheadedness, shortness of breath, or heart palpitations if these medicines are used together. This interaction is more likely to happen if you suffer from any heart disease (Arrhythmia) or have a family history of Arrhythmia. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.

  Quinidine

  You may experience dizziness, lightheadedness, and heart palpitations if these medicines are used together. Regular cardiac function tests are to be performed if you have any heart disease (Arrhythmia) or a family history of Arrhythmia. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.

  Antidiabetic medicines

  You may experience hypoglycemic effects like dizziness, headache, nervousness, confusion, tremor and weakness if these medicines are used together. Hyperglycemic effects like increased thirst, urination and hunger are less likely to occur. Regular blood glucose checkups are to be performed if you are diabetic or has any kidney disease. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.

  Aspirin

  You may experience tremors, involuntary muscle movements, hallucinations, or seizures if these medicines are used together. This interaction is more likely to happen if you have a history of seizures or family history of seizures. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.

  Ethinyl Estradiol

  The desired effect of contraceptive pills will not be achieved if these medicines are used together. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.

• Interaction with Disease

  Central Nervous System Depression

  If you suffer from CNS disorder and you take Change Tablet, then you may experience tremors, restlessness, anxiety, confusion and hallucinations. Avoid consuming caffeine containing products like coffee, chocolates and energy drinks.

  Colitis

  Avoid taking Change Tablet if you experience severe diarrhea, abdominal pain, and blood in stools after taking the medicine. Inform the doctor if you have any gastrointestinal diseases. Drink adequate amount of water to prevent dehydration.

  Qt Prolongation

  Avoid using Change Tablet if you experience any chest discomfort. Regular cardiac function tests are to be performed if you have any heart disease (arrhythmia) or family history of heart disease.

• Interaction with Food

  Dairy products

  The desired effect of Change Tablet is not observed if consumed with dairy products. There should be at least 2 hours gap between taking Change Tablet and dairy products.

• Ques : What is Change Tablet?

  Ans : Change Tablet is a medication which has Ofloxacin and Ornidazole as active elements present in it. This medicine performs its action by constricting the growth of microorganism, killing the infection causing bacteria. Change Tablet is used to treat conditions such as Eye and ear infection, Soft tissue infections, Bacterial infections, Bacterial infections by inflammation of the peritoneum, Skin infections, etc.

• Ques : What are the uses of Change Tablet?

  Ans : Change Tablet is a medication, which is used for treating infectious diarrhoea and dysentery.

• Ques : What are the Side Effects of Change Tablet?

  Ans : Change Tablet is a medication which has some commonly reported side effects. These side effects may or may not occur always and some of them are rare but severe. This is not a complete list and if you experience any of the below-mentioned side effects, contact your doctor immediately. Here are some side effects of Change Tablet which are as follows: Abdominal pain, Anxiety, Black or tarry stools, Confusion, Fever, Painful urination, Decreased appetite, Joint pain, Change in taste, Excessive air or gas in stomach, Runny Nose, Nausea and Vomiting, Sleeplessness, Dizziness, Change in pulse rate, Difficulty in breathing, Shaking of the hands or feet, Skin rash and itching, and Red spots on skin. It is a list of possible side-effects which may occur due to the constituting ingredients of Change Tablet.

• Ques : What are the instructions for storage and disposal Change Tablet?

  Ans : Change Tablet should be kept in a cool dry place and in its original pack. Make sure this medication remains unreachable to children and pets. The patient should consult a doctor for its further uses and side effects and should inform the doctor about any ongoing medications and treatment before using to avoid undesirable effects. It is a prescribed medication.

• Ofloxacin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 24 January 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/ofloxacin

• Ornidazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 24 January 2020]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/ornidazole

• Ofloxacin- DrugBank [Internet]. Drugbank.ca. 2020 [Cited 24 January 2020]. Available from:

  https://www.drugbank.ca/drugs/DB01165

• Ornidazole- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 24 January 2020]. Available from:

  https://www.drugbank.ca/drugs/DB13026