Ciplar 10 MG Tablet

Ciplar 10 MG Tablet is used for the management of hypertension, angina pectoris, pheochromocytoma, essential tremor, tetralogy of Fallot cyanotic spells, and arrhythmias (such as atrial fibrillation and flutter, A-V nodal re-entrant tachycardias, and catecholamine-induced arrhythmias).

It is also used in the prevention of myocardial infarction, migraine headache. Ciplar 10 MG Tablet is also helpful in treating the prevention of myocardial infarction, migraine headache.

This medication is a beta-blocking agent that attaches itself to the heart and inhibits the regular molecules from triggering the receptors. It blocks the beta-adrenergic receptors in the heart, thus slowing your heartbeat down and lowering the blood pressure. This lowers the stress placed on your heart, arteries, veins and blood vessels, decreasing the workload of the heart.

The medicine might not be suitable for everyone as it can have harmful effects on people with certain conditions. Before beginning a course of this medication, you need to notify your doctor if you are-

• Pregnant or breastfeeding, or
• Suffering from conditions such as:
• Asthma,
• Diabetes mellitus,
• Psoriasis,
• Liver or kidney problems,
• Severe heart condition.

The medicine must be taken according to the doctor’s prescription. The doctor might recommend taking it two, three or even four times a day. You must complete the course of this medication otherwise it can cause you to develop withdrawal symptoms.

Symptoms of intoxication include cardiac disturbances, CNS toxicity, bronchospasm, hypoglycemia and hyperkalemia. The most common cardiac symptoms include hypotension and bradycardia.

CNS effects include convulsions, coma, and respiratory arrest is commonly seen with Ciplar 10 MG Tablet and other membrane-depressant and lipid-soluble drugs.

Treatment includes symptomatic treatment of seizures, hypotension, hyperkalemia and hypoglycemia; bradycardia and hypotension resistant to atropine, isoproterenol or pacing may respond to glucagon.

wide QRS defects caused by the membrane-depressant poisoning may respond to hypertonic sodium bicarbonate; repeat-dose charcoal, hemoperfusion, or hemodialysis may be helpful.

Take exactly as directed; do not increase, decrease, or discontinue without consulting prescriber. Take at the same time each day. Tablets may be crushed and taken with liquids.

Report unusual swelling of extremities, difficulty breathing, unresolved cough, or unusual weight gain, cold extremities, persistent diarrhea, confusion, hallucinations, headache, nervousness, lack of improvement, or worsening of condition.

• Hypertension

• Angina Pectoris

• Migraine

• Anxiety

• Allergy

• Sinus Bradycardia

• Cardiogenic Shock

• Pregnancy

• Chest Pain

• Hypotension

• Cardiogenic Shock

• Light Headedness

• Confusion

• Dizziness

• Insomnia

• Fatigue

• Lethargy

• Cold Extremities

• Vertigo

• Syncope

• Hallucination

• Rash

• Alopecia

• Pruritus

• Urticaria

• Contact Dermatitis

• Diarrhoea

• Nausea

• Vomiting

• Stomach Discomfort

• Anorexia

• Impotence

• Thrombocytopenia

• Weakness

• Wheezing

• Bronchospasm

• Pharyngitis

• How long is the duration of effect?

  The effect of this medicine lasts for about 9 hours of duration.

• What is the onset of action?

  The effect of this medicine can be observed within an hour of administration.

• Are there any pregnancy warnings?

  Use of this medicine is not recommended for use in pregnant women as there is a lack of conclusive evidence from clinical studies.

• Is it habit forming?

  Mild to moderate habit forming tendencies have been reported and hence requires careful administration and withdrawal.

• Are there any breast-feeding warnings?

  The medicine is suggested to be ignored by breastfeeding mothers as there is a possibility of side-effects on the infant.

• Is It safe with alcohol?

  Consumption of alcohol along with Ciplar 10 MG Tablet is found to be unsafe. Thus it should be avoided.

• Is it safe to drive while on this medicine?

  You may experience orthostatic hypotension, dizziness, drowsiness, or blurred vision (use caution when driving, climbing stairs, or changing position - rising from sitting or lying to standing - or engaging in tasks requiring alertness until response to drug is known).

• Does this affect kidney function?

  This medicine is found to be safe to use in patient with kidney disease. Adjustment of dose is not needed. Dosing adjustment in renal impairment:

  • Clcr 31-40 mL/minute: Administer every 24-36 hours or administer 50% of normal dose.
  • Clcr 10-30 mL/minute: Administer every 24-48 hours or administer 50% of normal dose.
  • Clcr <10 mL/minute: Administer every 40-60 hours or administer 25% of normal dose.
  • Hemodialysis: Not dialyzable (0% to 5%); supplemental dose is not necessary.
  • Peritoneal dialysis: Supplemental dose is not necessary.

• Does this affect liver function?

  Caution must be taken in patient with liver disease. Adjustment of dose might be needed. Marked slowing of heart rate may occur in cirrhosis with conventional doses. Low initial dose and regular heart rate monitoring. Kindly consult your doctor before taking it.

Below is the list of medicines, which have the same composition, strength and form as Ciplar 10 MG Tablet , and hence can be used as its substitute.

• Provanol 10 MG Tablet

  Intas Pharmaceuticals Ltd

• Inderal 10 MG Tablet

  Abbott India Ltd

• Manoprolol 10 MG Tablet

  Orchid Chemicals & Pharmaceuticals Ltd

• Betacap 10 MG Tablet

  Sun Pharma Laboratories Ltd

• Migrabeta 10 MG Tablet

  Alkem Laboratories Ltd

• Are there any missed dose instructions?

  Take the missed dose as soon as you remember. The missed dose can be skipped if it is almost time for the next scheduled dose.

• Are there any overdose instructions?

  Report any incidence of overdose to the doctor immediately.

This medicine non-selectively blocks beta receptors sites in the heart, blood vessels, lungs and other organs. Thus, the pressure is lowered and blood flow in the heart and other organs is improved

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Avoid or limit the use of alcohol while you are taking this medicine. Any activity requiring a high level of mental alertness like operating heavy machinery or driving should be avoided.

• Interaction with Medicine

  • Alpha-blockers (prazosin, terazosin): Concurrent use of beta-blockers may increase risk of orthostasis.
  • Antipyrine's clearance is reduced by 30% to 40%.
  • Cimetidine increases the plasma concentration of Ciplar 10 MG Tablet and its pharmacodynamic effects may be increased.
  • Clonidine: Hypertensive crisis after or during withdrawal of either agent.
  • Drugs which slow AV conduction (digoxin): Effects may be additive with beta-blockers.
  • Epinephrine (including local anesthetics with epinephrine): Ciplar 10 MG Tablet may cause hypertension.
  • Flecainide: Pharmacological activity of both agents may be increased when used concurrently.
  • Fluoxetine may inhibit the metabolism of Ciplar 10 MG Tablet, resulting in cardiac toxicity.
  • Glucagon: Ciplar 10 MG Tablet may blunt hyperglycemic action.
  • Haloperidol: Hypotensive effects may be potentiated.
  • Hydralazine: The bioavailability propranolol (rapid release) and hydralazine may be enhanced with concurrent dosing.
  • Insulin: Ciplar 10 MG Tablet inhibits recovery and may cause hypertension and bradycardia following insulin-induced hypoglycemia. Also masks the tachycardia that usually accompanies insulin-induced hypoglycemia.
  • NSAIDs (ibuprofen, indomethacin, naproxen, piroxicam) may reduce the antihypertensive effects of beta-blockers.
  • Salicylates may reduce the antihypertensive effects of beta-blockers.
  • Sulfonylureas: Beta-blockers may alter response to hypoglycemic agents.
  • Verapamil or diltiazem may have synergistic or additive pharmacological effects when taken concurrently with beta-blockers; avoid concurrent I.V. use of both.

• Interaction with Disease

  • Administer cautiously in compensated heart failure and monitor for a worsening of the condition (efficacy of propranolol in CHF has not been demonstrated).
  • Avoid abrupt discontinuation in patients with a history of CAD; slowly wean while monitoring for signs and symptoms of ischemia.
  • Use caution in patient with PVD.
  • Use cautiously in diabetics because it can mask prominent hypoglycemic symptoms.
  • Can mask signs of thyrotoxicosis.
  • Can cause fetal harm when administered in pregnancy.
  • Use cautiously in hepatic dysfunction (dosage adjustment required).
  • Use care with anesthetic agents which decrease myocardial function.

• Interaction with Food

  Avoid natural licorice (causes sodium and water retention and increases potassium loss); protein-rich foods may increase bioavailability; a change in diet from high carbohydrate/low protein to low carbohydrate/high protein may result in increased oral clearance.

• Ques : What is Ciplar 10 MG Tablet?

  Ans : This medication is a salt drug that acts as a beta-blocker that is used for the treatment and prevention of diseases such as high blood pressure, irregular heartbeats, migraine headaches, and angina pectoris.

• Ques : What are the uses of Ciplar 10 MG Tablet?

  Ans : This is a medication, which is used for the treatment and prevention from conditions such as high blood pressure, irregular heartbeats, migraine headaches, and angina pectoris.

• Ques : What are the Side Effects of Ciplar 10 MG Tablet?

  Ans : Side effects include dizziness, lightheadedness, stomach pain, vision changes, sleeping troubles, vomiting, nausea, and swollen ankles or feet.

• Ques : What are the instructions for storage and disposal Ciplar 10 MG Tablet?

  Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

• Ques : When can I expect relief in my symptoms after starting Ciplar 10 MG Tablet for high blood pressure?

  Ans : It usually starts working within a few hours of taking it. However, it may take up to a week to see the full benefits of the symptoms of high blood pressure or heart conditions.

• Ques : Is Ciplar 10 MG Tablet effective?

  Ans : Yes, it is effective if used in the dose and duration advised by your doctor. Do not stop taking it even if you see improvement in your condition. If you stop using this medication too early, the symptoms may return or worsen.

• Ques : Can Ciplar 10 MG Tablet be used in asthmatics?

  Ans : No, Ciplar 10 MG Tablet cannot be used in asthmatics. This is because using this drug in asthma patients can cause breathing problems, which may trigger an asthma attack. It is advised to take medical consultation.

• Ques : What if I forget to take a dose of Ciplar 10 MG Tablet?

  Ans : If you forget a dose of this drug, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time.

• Ques : Can I stop taking Ciplar 10 MG Tablet as my chest pain is under control?

  Ans : No, you should not stop taking this medication suddenly because that may worsen your angina or may cause a heart attack. It is advised to complete the proper dose prescribed by your doctor.

• Ques : Is Ciplar 10 MG Tablet safe?

  Ans : Yes, it is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.

• Ques : What if I take an overdose of Ciplar 10 MG Tablet?

  Ans : If you take an overdose of this drug you may experience symptoms such as slow heartbeat, trembling, difficulty breathing or dizziness.

• Ques : Does Ciplar 10 MG Tablet relieve anxiety?

  Ans : Yes, it helps relieve the symptoms of anxiety such as irritability, restlessness, excessive worry, lack of concentration, racing or unwanted thoughts, fatigue, insomnia (lack of sleep), palpitations (irregular heart rate), or trembling.

• Propranolol- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 25 April 2019]. Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/propranolol

• Propranolol 10 mg film-coated tablets- EMC [Internet]. www.medicines.org.uk. 2018 [Cited 08 May 2019]. Available from:

  https://www.medicines.org.uk/emc/product/2903/smpc

• PROPRANOLOL HYDROCHLORIDE- propranolol hydrochloride capsule, extended release- Daily Med [Internet]. dailymed.nlm.nih.gov. 2015 [Cited 25 April 2019]. Available from:

  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a4edba76-29b8-41fb-bf0b-d4633abba003