Cleft 20Mg Tablet

Cleft 20Mg Tablet is an immunosuppressive disease-modifying antirheumatic drug. It is a pyrimidine synthesis inhibitor. It is used to treat rheumatoid arthritis. It functions by reducing joint pain and swelling.

Certain side-effects that you may experience on using Cleft 20Mg Tablet are dizziness, nausea, diarrhoea, hair loss, headache, respiratory tract infections, cough, difficulty breathing, stomatitis, fatigue, itchiness and pharyngitis. Should your allergic reactions continue or worsen over time, immediately contact your health care provider.

Before using Cleft 20Mg Tablet have a word with your doctor and inform him/her if: you are allergic to any medication, food, substance or any ingredient contained within Cleft 20Mg Tablet, you are pregnant, or are planning to become pregnant or are nursing a baby, you have a weak immune system, you have liver, lung or kidney problems and if you are taking any prescription or non-prescription drugs.

The dosage should be ideally prescribed by your doctor. This medication comes in a tablet form. Usually the adult dose for Cleft 20Mg Tablet is about 20 mg (maintenance dose) to be taken through the mouth once for over a period of 3 days.

If diabetic, monitor blood sugars closely; this medication may alter glucose levels. There is no human experience with overdosage. Cleft 20Mg Tablet is not dialyzable. Cholestyramine and/or activated charcoal enhance elimination of leflunomide's active metabolite (MI).

In cases of significant overdose or toxicity, cholestyramine 8 g every 8 hours for 1-3 days may be administered to enhance elimination. Plasma levels are reduced by approximately 40% in 24 hours and 49% to 65% after 48 hours of cholestyramine dosing.

Take as directed; do not increase dose without consulting prescriber. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). Store medication away from light.

Cleft 20Mg Tablet has been associated with teratogenic and embryolethal effects in animal models at low doses. Cleft 20Mg Tablet is contraindicated in pregnant women or women of childbearing potential who are not using reliable contraception.

Pregnancy must be excluded prior to initiating treatment. Following treatment, pregnancy should be avoided until the drug elimination procedure is completed.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Rheumatologist before using this medicine.

• Rheumatoid Arthritis

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Rheumatologist before using this medicine.

• Hypersensitivity

• Pregnancy

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Rheumatologist before using this medicine.

• Diarrhoea

• Hypertension

• Chest Pain

• Headache

• Dizziness

• Pain

• Fever

• Migraine

• Anxiety

• Depression

• Insomnia

• Sleep Disorders

• Alopecia

• Rash

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Rheumatologist before using this medicine.

• Is It safe with alcohol?

  Taking Cleft 20Mg Tablet with alcohol may cause liver problems.

• Are there any pregnancy warnings?

  Cleft 20Mg Tablet is highly unsafe to use during pregnancy.
  Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.

• Are there any breast-feeding warnings?

  This drug may cause severe fetal defects. Do not breast-feed. Please consult your doctor.

• Is it safe to drive while on this medicine?

  Caution is advised when driving or operating machinery.

• Does this affect kidney function?

  No specific dosage adjustment is recommended. There is no clinical experience in the use of Cleft 20Mg Tablet in patients with renal impairment. The free fraction of MI is doubled in dialysis patients. Patients should be monitored closely for adverse effects requiring dosage adjustment.

• Does this affect liver function?

  No specific dosage adjustment is recommended. Since the liver is involved in metabolic activation and subsequent metabolism/elimination of Cleft 20Mg Tablet, patients with hepatic impairment should be monitored closely for adverse effects requiring dosage adjustment.

• What is the onset of action?

  The effect of this medicine is initiated within 2 hours after its administration.

• How long is the duration of effect?

  The effect of this medicine will remain for about 12 - 14 hours.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Rheumatologist before using this medicine.

Below is the list of medicines, which have the same composition, strength and form as Cleft 20Mg Tablet , and hence can be used as its substitute.

• Rumalef 20mg Tablet

  Zydus Cadila

• Lefumide 20Mg Tablet

  Cipla Ltd

• Immulef 20mg Tablet

  Ronyd Healthcare Pvt Ltd

• Lefno 20Mg Tablet

  Ipca Laboratories Ltd

• Lefra 20Mg Tablet

  Torrent Pharmaceuticals Ltd

• Lefrhum 20Mg Tablet

  Rhumasafe Pharmaceutical

• Leflunomide 20Mg Tablet

  Ranbaxy Laboratories Ltd

• Lefron 20Mg Tablet

  Ronyd Healthcare Pvt Ltd

• Dm Lef 20Mg Tablet

  Overseas Healthcare Pvt Ltd

• Arava 20Mg Tablet

  Sanofi India Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Rheumatologist before using this medicine.

• Are there any missed dose instructions?

  If you miss a dose of Cleft 20Mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Rheumatologist before using this medicine.

Cleft 20Mg Tablet is a prodrug with anti-inflammatory and immunosuppressive properties that works by breaking down into its active metabolite A77 1726 once ingested which then blocks an important enzyme for de novo pyrimidine synthesis, dihydroorotate dehydrogenase. This inhibits the growth of activated T-lymphocytes.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Rheumatologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Medicine

  Decreased effect: Administration of cholestyramine and activated charcoal enhance the elimination of leflunomide's active metabolite.

• Interaction with Disease

  • Hepatic disease (including seropositive hepatitis B or C patients) may increase risk of hepatotoxicity; immunosuppression may increase the risk of lymphoproliferative disorders or other malignancies;
  • Women of childbearing potential should not receive Cleft 20Mg Tablet until pregnancy has been excluded, patients have been counseled concerning fetal risk and reliable contraceptive measures have been confirmed.
  • Caution in renal impairment.
  • Not recommended for patients with severe immune deficiency, bone marrow dysplasia or uncontrolled infection.
  • Has been associated with rare pancytopenia; use with caution in patients with a prior history of significant hematologic abnormalities.
  • Discontinue if evidence of bone marrow suppression occurs, and begin procedure for accelerated removal (cholestyramine and activated charcoal).
  • The use of live vaccines is not recommended.
  • Cleft 20Mg Tablet will increase uric acid excretion.

• Ques : What is Cleft 20Mg Tablet?

  Ans : Cleft 20Mg Tablet is an immunosuppressive disease-modifying antirheumatic drug. It is a pyrimidine synthesis inhibitor.

• Ques : What is Cleft 20Mg Tablet used for?

  Ans : It is used to treat rheumatoid arthritis. It functions by reducing joint pain and swelling.

• Ques : How long do I need to use Cleft 20Mg Tablet before I see improvement in my condition?

  Ans : In most of the cases, the average time taken by this medication to reach its peak effect is around 1 day to 1 week. Please consult your doctor for the time period you need to use this medication.

• Ques : At what frequency do I need to use Cleft 20Mg Tablet?

  Ans : This medication is generally used once or twice a day. It is advised to consult your doctor before the usage, as the frequency also depends on the patient's condition.

• Ques : Should I use Cleft 20Mg Tablet empty stomach, before food or after food?

  Ans : This medication is advised to be consumed orally. If you take it on an empty stomach, it might upset the stomach. Please consult the doctor before using it.

• Ques : What are the instructions for the storage and disposal of Cleft 20Mg Tablet?

  Ans : It should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

• Ques : How long does Cleft 20Mg Tablet take to work?

  Ans : Usually, Cleft 20Mg Tablet starts working soon after taking it. However, it may take some days to kill all the harmful bacteria and make you feel better.

• Ques : What if I don't get better after using Cleft 20Mg Tablet?

  Ans : Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform him if your symptoms are getting worse while using this medicine.

• Ques : Can Cleft 20Mg Tablet cause weight loss?

  Ans : Yes, Cleft 20Mg Tablet may cause weight loss as a common side effect. However, weight loss due to this medicine is usually insignificant. The reason for this reduction in weight could be due to accompanying loss of appetite.

• Ques : Can Cleft 20Mg Tablet cause cancer?

  Ans : Cleft 20Mg Tablet may increase your chances of cancer, especially of the lymph system, but this is very rare. The reason could be decreased strength of the immune system caused by Cleft 20Mg Tablet.

• Leflunomide-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 2 June 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/leflunomide

• Leflunomide-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 2 June 2022].Available from:

  https://go.drugbank.com/drugs/DB01097

• LEFLUNOMIDE Tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 2 June 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=LEFLUNOMIDE